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姓 名: | ××× | 性别: | F | 年龄: | 49 |
标本名称: | Breast excisional biopsy (乳腺切除活检) | ||||
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肉眼检查: |
Microscopically it is a 0.8 cm lesion as photo.
Your diagnosis and differential diagnosis.
(镜下病变直径0.8cm,如图。请诊断和鉴别诊断)
回22楼和26楼:
需要在微腺性腺病和浸润癌之间鉴别。腺腔小,较一致,腺体周围似有肌上皮混杂,支持微腺性腺病。但部分腺上皮异型性明显,关键是脂肪组织中有浸润。不能除外癌。必须做P63,CK5/6和SMA等肌上皮标记。
期待Dr. Zhao的讲解。。。。。。
stevenshen 离线
Florid small glandular proliferation with infiltration of stroma and fat = microglandular adenosis pattern; marked cytologic atypia including prominent nucleoli; stroma alteration more than that of benign microglandular adenosis. Morphologic diagnoses infiltrating ductal carcinoma with microglandular adenosis pattern or arising from microglandular adenosis. IHC stain with myoepithelial markers and collagen IV and S100 (as described by Dr. Zhao) will be help to confirm the diagnosis. Never seen such a case. Look forward to hearing about the final diagnosis. Thanks.
abin译:小腺体旺炽性增生,浸润间质和脂肪,这是微腺腺病的生长方式;有明显的细胞学非典型性,包括明显核仁;间质的改变也超出了良性微腺腺病的程度。
形态学诊断:呈微腺腺病结构的浸润性导管癌,或发生于微腺腺病的浸润性导管癌。
作肌上皮标记和S-100免疫组化以及胶原IV染色有助于确诊。从未见过这样的病例。期待最后诊断。
谢谢。