50 岁妇女乳腺肿瘤2.5cm

. Fig 1-4. most areas of the tumor.

我们在平常工作中也会出现这种情况，我们就冠个总名：浸润性癌，部分区域为浸润性小叶癌，部分区域为浸润性导管癌。不知道赵老师那边是怎样规范的报告？还有是否国外在报告ER，PR时要报%吗？就像ki-67那样+>30%之类的吗？谢谢您！

ToSOS991229 

You can see our breast ca report sample in the follow link.

http://www.ipathology.com.cn/forum/forum_display.asp?keyno=115037

Different hospitals can be different in term of the report.

 1浸润性小叶癌

2小叶原位癌

3小叶癌伴浸润

4小管癌

We do er/pr/her2/ki67 for all cases of invasive breast ca

I mentioned Her2 report before. I think the Her2 reort is similar among most hospitals in China and the US.

Currently we report ER/PR and ki67 as following.

ER/PR: H score:

example:

ER positive, H score 240 (0 10%; 1+10%; 2+10%; 3+70%)

H score count: (3x70=210)+(2x10=20)+(1x10=10)+(0x10=0) =240

Tumor cell proliferation index (Ki67):

Result 40%,

Index high (low: to 10%; moderate:11-25%; high:26-50%; very high:>50%)

Magee is a breast and gynecologic center. Our reports are very detailed. The report systems can be very variable in different hospitals.

Just for your reference

 All of you are right about the tumor.

Stains for the main tumor or fig1 (question 1)

E-cad and P120

interpretaion of P120: lobular lesion-cytoplasmic stain; ductal lesion-membrane stain.

We will have the answers for others one by one soon.

名称：图1
描述：图1

名称：图2
描述：图2

非常感兴趣的病例，但是我有些疑问：

1）文献中有tubulolobular carcinoma 的名称，应该如何理解？

2）能否提供小管癌区域的免疫组化标记片？

3）诊断时是否因为浸润性小叶癌的恶性程度高而可忽略其他成分？

Thank for your attention.

1) + 2): will show the IHC results of other areas and have some discussion one by one.

3）诊断时是否因为浸润性小叶癌的恶性程度高而可忽略其他成分？

No. We report all abnormal lesions in the reports in our hospital.

For example:

Invasive ductal or lobular ca

in site ca (DCIS or LCIS)

Atypical lesions: ADH, ALH, atypical papilloma, FEA

Will have one dx line to include all non-neoplastic breast lesions such as FCC, sclerosing adenosis, introductal papilloma, UDH, radial scar, CCC, calcification....

 Area 2.

1. H&E

2. E-cadherin

3. P120

4. P63

5. smooth muscle myosin heavy chain

名称：图1
描述：图1

名称：图2
描述：图2

名称：图3
描述：图3

名称：图4
描述：图4

名称：图5
描述：图5

 Now I showed you the IHC results.

Questions:

Are these tumor nests invasive or in situ tumor?

Are they lobular or ductal ca?

What did you think they were based on the H&E only? Why?

IHC染色很棒

学习了谢谢