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姓 名: | ××× | 性别: | 女 | 年龄: | 42 |
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简要病史: | 乳腺肿物 | ||||
肉眼检查: |
low-grade phylloides tumor
phylloides tumor的分级目前有三级和两极分类,兹摘要如下:
⑴WHO(2003)女性生殖和乳腺肿瘤分类中,依据核分裂数肿瘤界限类型、间质过度增生程度和细胞多形性分为良性、交界性和恶性。然而,即便组织学良性者也可复发,甚而有转移者;
⑵Rosen's Breast Pathology 3ed.有关phylloides tumor的分级与WHO(2003)相同;
⑶AFIP(2009) Series 4 Tumors of the Mammary Gland中将肿瘤分为low-grade and high-grade,他们主张用术语low-grade(低级别) 而不用良性(benign)phylloides tumor,因为其行为很难预见,即使是组织学良性肿瘤。low-grade phylloides tumor:推挤型边界、轻至中度非典型性、<3个核分裂/10HPFs,这些肿瘤局部复发,转移可能性极小。High-grade:肿瘤有远处转移潜能,特征:浸润或推挤型边界、中至重度非典型性、≥3个核分裂/10HPFs,肉瘤样过增生间质也属于此级别。此外,还有来源于phylloides tumor的其他特殊型肉瘤也属于该级别。
⑷Moinfar F编著的Essentials of Diagnostic Breast Pathology中该肿瘤的分级观点与AFIP相同。
上述两级分类的low-grade包含三级分类的良性和交界性病变,因为后者主要是局部复发。
通过学习我个人支持两级分类,尤其是诊断中避免用“良性”而改用“低级别”更能客观的评价。
Above introduction of the two systems are very good. Thanks,
We used low and high grades system when I was at afip, and currently we use WHO system. I think most hospitals use WHO system in the US.
The important is that your clinicians know what are you talking about and also you should be consistent with the terminology.
For this case I agree it is like a low grade phyllodes if you use two tier system and it may be a benign or borderline phyllodes based on cellularity, atypica, margin, mitosis as 七公主 mentioned if you use three tier system.