这一例是AFIP的会诊切片。

原切片的诊断是：Left ovary: Mucinous tumor of low malignant potential (Mullerian/endocervical-like) with extensive intraepithelial carcinoma (see comment)

COMMENT:

The staff essentially concurs with your diagnosis of a mucinous tumor of low malignant potential based on the atypical proliferative mucinous glands with prominent epithelial stratification and tufting as well as hyperchromatic, atypical nuclei. There is extensive glandular crowding and a confluent (back-to-back) growth pattern, without evidence of destructive/infiltrative stromal invasion, features of intraepithelial carcinoma. In the past at the AFIP, this type of lesion with its marked stratification, nuclear atypia and abundant mitoses would have been regarded as a mucinous cystadenocarcinoma. However, presently, tumors such as these without definite stromal invasion do not qualify as mucinous cystadenocarcinoma. Hence, the designation “mucinous tumor as one of low maglignant potential with extensive intraepithelial carcinoma” is preferred in this case (Am J Surg Pathol, 23(6):617-635, 1991 and Am J Surg Pathol 24(11):1447-64, 2000).