This is today's case. Paste here for my first case of 2011.

25 y/f routine Pap test. Previous two Pap tests were normal (1 and 4 years ago)

哪敢在巴老面前谈总结啊，呵呵，阿彬确实善总结，我只是因为来晚了。

学习到：思维不能定势，有疑问要查资料。肠型AIS没有诊断经验只在书上看过，也是一个借口

总算把这个长达6页的例子看过了，受益匪浅！

非常感谢赵老师的精心讲解和大家的勇跃参与！

细胞学图片，认真看来，确实图一够H，图二至少AGC-N。

组织学片上看，赞同报CIN2累腺、AIS。——那些腺体上皮层次不齐、核大小不一、可见一个分裂像。

肠型原位癌的局部确实给人以良性的假象，但是，综合来看本例还是符合AIS的。

看过大家的贴子，我才有以上心得的吧。

谢谢！

 原来是肠型AIS啊！多谢Dr.cqzhao指教！

我只注意了宫颈型的那张图

 Now I hope all of you would agree my dx of AIS and CIN2 with glandular involvement. I have no more to say if you still do not buy my dx.

Cytology-histology-IHC

What do you learn from this case of 25 year young women?

 Fig 1: Ki67 200x

Fig 2: P16 200x

Both glandular and squamous cells are strongly positive for ki67 (nuclear) and p16.

名称：图1
描述：图1

名称：图2
描述：图2

It is a good way to study the cytology cases with histological follow-up results.

赞同，学习！

谢谢。

 I quickly reviewed above interpretation or diagnosis.

Most of people made reasonal interpretation for Pap cytology.

掌心0164 made an excellent diagnosis in cervical histology.

Thank all people who read and wrote your diagnosis for this case.

It is a good way to study the cytology cases with histological follow-up results.

 The original Pap cytology we interpretated as

HSIL

AGC, endocervical.

I think ASC-H is also a reasonal call.

 About 50% cases of cervical AIS or invasive adenocarcinoma can have CIN2/3 lesions.

 Three major subtypes of AIS:

Endocervical or typical type

Interestinal type (mucin-rich goblet cells)

Endometrioid type

AIS, inerestinal type. In this type, nuclei can look not urgly.

Whenever you see goblet cells in Pap cytology or cervical cytology, you need to be cautious.

AIS:

Pseudostratification or stratification

Enlarged and dark nuclei.

Occasional mitosis