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姓 名: | ××× | 性别: | 女 | 年龄: | 25岁 |
标本名称: | 右卵巢肿块 | ||||
简要病史: | 足月顺产2个月后,自觉右下腹包块,无腹痛,无不规则阴道流血及异常阴道排液。妇科检查:右附件区扪及约10×7cm大小的肿块,质硬,活动差,无压痛。盆腔CT示右侧附件占位,伴有盆腔积液 | ||||
肉眼检查: | 右侧卵巢肿瘤大小约9.5×8.5×6cm,有包膜,表面光滑,略呈分叶状。切面灰黄色,部分呈桔黄色,局灶伴出血和微囊变,质地偏硬。 |
请将思路再放开一些。
请见国外一篇文章的前言,讲的是AFP不只是生殖细胞肿瘤,而在一些非生殖细胞的女性肿瘤中也可表达。
Elevated levels of alpha-fetoprotein (AFP), a foetal serum protein,occur on the development of hepatocellular carcinoma(HCC) or germ cell tumours, including yolk sac tumour (YST) and embryonal carcinoma of the ovary. Hence, AFP is a useful tumour marker for germ cell tumours of the ovary and is valuable for both diagnosis and follow-up.
There are non-germ cell tumours of the female genital tract that have been reported to produce AFP. These include different types of carcinomas, carcinosarcomas and sex cord stromal tumours. As the female genital tract is the site of germ cell tumours, it is important to be aware of other AFP-producing tumours, which should be considered in the differential diagnosis of tumours in patient with elevated serum AFP. This article reviews AFP-producing non-germ cell tumours reported in different parts of the female genital tract and discusses the distinction between these entities and YST.