Ming SC, Bajtai A, Correa P, Elster K, Jarvi OH, Munoz N, Nagayo T, Stemmerman
GN. [ Gastric dysplasia. Significance and pathologic criteria.]
Cancer. 1984;54:1794-801.
In view of uncertainty regarding the criteria and significance of gastric dysplasia as a precancerous lesion, members of the Pathology Panel of the International Study Group on Gastric Cancer (ISGGC) reviewed microslides of 93 gastric lesions showing varying degrees of mucosal abnormality, and reached the following consensus:
(1) immature and proliferating gastric epithelium can be divided into two categories: hyperplastic and dysplastic;
(2) the term dysplasia, especially of high-grade type, should be restricted to precancerous lesions, and hyperplasia is applied to regenerative changes;
(3) regenerative hyperplasia may be simple or atypical, but dysplasia includes both moderate and severe abnormalities, since they often coexist and can not be sharply separated;
(4) occasionally the possibility of malignancy can not be excluded in a severely
dysplastic epithelium; in such a case rebiopsy and diligent follow-up are necessary to establish the diagnosis.
Criteria for diagnosing dysplasia and hyperplasia are presented and discussed. The opinions are offered as guidelines for establishing the diagnosis of gastric dysplasia and for prospective studies.
1984年国际胃癌研究协会病理组专家在复习了93例不同程度异常的胃粘膜后，达成共识：
1）未成熟和增殖性粘膜异常可分成2类，增生性和异型增生性；
2）异型增生的术语，特别是高级别型，必须限制于癌前病变，增生用于再生性改变；
3）再生性增生可以是单纯性或者不典型性，而异型增生包括中度和重度异常，由于再生性增生和异型增生常常同时存在，不能被明确的区分。
4）偶尔，重度异型增生的上皮存在癌性病变的可能性不能除外，对这种病例必须重复活检和勤随访以确定诊断。
