，纤维成分中部分为癌性间质。 
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- B1585左乳肿块
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左乳肿块
女44，左乳肿块3*3*2厘米
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标签：乳腺浸润性导管癌
朱正龙
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ZQH19811029 离线
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It may be a invasive ductal carcinoma. You have to order IHC for myoepithelial markers (p63, smooth muscle heavy chain or SMA) to differentiate IDC from sclerosing adenosis in clinical practice if you are not 100% sure. Also you can order the IHC stains for E-cadherin and p120 to differentiate ductal carcinoma from lobular carcinoma.
Ductal carcinoma (invasive+in situ): E-cadherin and p120, both positive with membrane stain.
Lobular carcinoma (invasive +in situ): E-cadherin negative, p120 with diffuse cytoplasmic stain.
p120 is better than E-cadherin if one stain is ordered. In most cases I always order both.
| 以下是引用stevenshen在2008-10-12 3:58:00的发言：
It is difficult to be sure based on the photos provided. I also worry about infiltrating carcinoma; but be sure to rule out the possibility of lobular carcinoma in-situ, sclerosing adenosis with involvement of LCIS. Look forward to hearing the final answer. |
同感！
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stevenshen 离线
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It is difficult to be sure based on the photos provided. I also worry about infiltrating carcinoma; but be sure to rule out the possibility of lobular carcinoma in-situ, sclerosing adenosis with involvement of LCIS. Look forward to hearing the final answer.
