Whenever you have a bilateral malignant tumor with high grde features like this one, you should first to rule out a metastatic carcinoma. High grade serous adenocarcinoma is on the top differential list for primary ovarian carcinoma since bilaterality is not uncommon in serous adenocarcinoma. One of the useful markers is to see if tumor cells are positive for WT-1, a marker often labeling mullerian epithelium. Also up to 50% of serous adenocarcinoma will be positive for ER and PR. For metastatic cancer (mostly from GI tract), CK20 is a good marker to differentiate metastatic carcinoma from coorectal or stomach from primary serous adenocarcinoma, provide no mucinous differentiation seen in this tumor anywhere else.
Whenever you have a bilateral malignant tumor with high grde features like this one, you should first to rule out a metastatic carcinoma. High grade serous adenocarcinoma is on the top differential list for primary ovarian carcinoma since bilaterality is not uncommon in serous adenocarcinoma. One of the useful markers is to see if tumor cells are positive for WT-1, a marker often labeling mullerian epithelium. Also up to 50% of serous adenocarcinoma will be positive for ER and PR. For metastatic cancer (mostly from GI tract), CK20 is a good marker to differentiate metastatic carcinoma from coorectal or stomach from primary serous adenocarcinoma, provide no mucinous differentiation seen in this tumor anywhere else.