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- B1271请教，绒毛水肿？还是葡萄胎
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liyong7979 离线
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Sorry i feel different from above experts. I feel i cannot exclude complete mole. There is mild trophoblastic proliferation in some villi and some pictures show cistern-like spaces. Although not sure, it seems that there are no blood vessels in the stroma and i don't see nucleated red blood cells (fetal tissue). Nowaday with HCG monitoring and ultrasound, complete moles can present in very early stage before classic features develop. p57 is a very powerful tool to diagnose complete moles. If we are suspecting partial moles, we do chromosomal analysis.
I admit we don't see molar pregnancy here as much as in China. Maybe i am overworried.
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vitamin-xbl 离线
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p57 interpretation is very tricky. The positivity of cytotrophoblasts means positive. Intervillous trophoblasts are always postive, and is used as internal control. Positive p57 is seen in non-molar villi or partial mole, excludes complete mole. Complete mole is negative for p57 in cytotrophoblasts and intervillous trophoblasts will be positive. So, positive p57 does not differentiate between partial mole or edema. The partial mole diagnosis must be based on other features. Chromosomal analysis confirms it (trisomy or other).
