These photos are taken from brain, spinal cord, nerve roots, and dorsal root gangia removed from a 59 year-old woman at autopsy. All sections were stained by the luxol fast blue/H&E method. The patient experienced worsening numbness and weakness of lower extremities with difficulty walking for 6 months prior to death due to pneumonia and secondary sepsis. Left sural nerve biopsy and gastrocnemius muscle biopsy prior to death showed severe axonal neuropathy and chronic neurogenic atrophy, respectively. Brain MRI was normal. What is your diagnosis?
1. Left frontal lobe neocortex
2-3. Left transentorhinal cortex
4. Substantia nigra
5. Nucleus of oculomotor nerve (midbrain)
6. Cerebellar cortex
7-8. Cerebellar dentate nucleus
9. Basis pontis
10-11. Inferior olivary nucleus of medulla oblongata
12. Lumbar spinal cord
13. Anterior nerve root (lumbar)
14. Posterior nerve root (lumbar)
15-16. Lumbar dorsal root ganglion
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