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性别 | 男 | 年龄 | 34岁 | 临床诊断 | 左鼻腔肿块 |
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一般病史 | 发现左鼻腔肿块3月余。 | ||||
标本名称 | 鼻腔肿块活检 | ||||
大体所见 | 不规则组织1块,大小约0.8×0.6×0.6cm,表面可见黑色毛发,切面灰白,半透明,质中等。 |
图片1、2、3分别为显微镜下低倍、中倍和高倍视野所见。
图4为市一南院外景。
巨细胞血管纤维瘤(Giant cell angiofibroma)鉴别于巨细胞纤维瘤在于强表达CD34,据说是孤立性纤维性肿瘤的一种特殊变异类型。
Ophthal Plast Reconstr Surg. 2009 Sep-Oct;25(5):402-4. doi: 10.1097/IOP.0b013e3181b39a15.
Oncology Service and daggerPathology Department, Wills Eye Institute, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
A 16-year-old girl presented with diplopia and gradual-onset, painless proptosis of the left eye. Orbital CT showed a well-circumscribed, enhancing, extraconal mass in the superior orbit, and the surgical excision was performed. Histopathology was interpreted as capillary hemangioma. Five years later, her symptoms recurred, and she was referred to the Oncology Service, Wills Eye Institute. Repeat orbital MRI showed a well-defined, extraconal mass with loculated areas of enhancement in the left orbit superonasally. Complete surgical excision was performed. Histopathologic examination showed benign, patternless spindle-cell proliferation with prominent intrinsic vascularity and multinucleated giant cells, consistent with giant cell angiofibroma, a variant of solitary fibrous tumor. There was intense immunoreactivity for CD34. After 20 months follow-up, there was no recurrence or development of metastasis. Giant cell angiofibroma, a variant of solitary fibrous tumor, is a rare orbital tumor that presents as a well-circumscribed, enhancing mass and can be found in children.