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- 2012年第38期——双侧卵巢肿块（已点评）
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53 y/f with bilateral adnexal masses and anterior abdominal wall nodule and peritoneal effusion. Regular CT examination showed bilateral ovarian masse measuring 10 and 8 cm, respectively; lung negative, pancrease, gastric negative findings also. Patient has no previous malignant history.
《永恒爱恋老师友情帮助翻译》：女，53岁，双附件巨大肿块，之前有腹部质硬结节伴腹膜渗出物；CT检查示双侧附件巨大肿块，大小分别约为10cm和8cm，肺、胰腺、胃均无异常发现，患者无恶性肿瘤病史。
Core biopsy was performed for anterior andominal wall nodule.
行腹部质硬结节细针穿刺活检
Three core biopsy specimen showed benign fibroadipose tissue. Only one core demonstrate focal epithelial lining.
See the photos：
见图：
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Please descript
请描述
1. Your analysis and impression for this core biopsy
1、您对此穿刺活检标本的分析和看法
2. If you want to order some stains, what stains will you order? Only three unstained slides are avaiable due to the scant tissue.
2、如果您觉得需要做免疫组织化学染色，会选择哪些标记，剩余的组织只可用来做三张染色。
本例点评：赵澄泉老师
（以下由：蔷薇老师友情帮助翻译！）53岁女性，双侧附件肿块，前腹壁结节，有腹水。常规CT检查显示双侧卵巢肿块分别为10cm及8cm；双肺、胰腺、胃未见特殊。患者无恶性肿瘤病史。
行前腹壁肿块粗针穿刺活检。
三条组织呈良性纤维脂肪组织。仅1条组织见局灶上皮被覆。
如图片所示：
请给出如下所述。
1 您对该活检的分析及诊断
2 如果需特殊染色，请列出那些特殊染色。由于组织有限，仅有3张白片。
点评专家：赵澄泉（113楼 链接：>>点击查看<< ）
获奖名单：雅马哈（1楼 链接：>>点击查看<< ）
标签：卵巢肿块
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本帖最后由 筷子 于 2013-05-09 18:28:41 编辑
×参考诊断
Based on the requirement from the patient or clinician, the Tissue of Origin Test (from block) was performed by Pathwork Diagnostics (Redwood City, CA).
A. Most likely tissue of origin: PANCREAS (Degree of confidence: MODERATELY HIGH; Similarity Score-SS 41.6) (see note).
B. Tissues ruled out: Sarcoma, Breast, Non-Small Cell Lung, Bladder, Thyroid, Melanoma, Kidney, Hepatocellular, Hon-Hodgkin Lymphoma, Testicular Germ Cell, Prostate.
TISSUE OF ORIGIN TEST
TISSUE Similarity score:
Pancreas 41.6
Gastric 25.6
Colorectal 13.5
Ovarian 7.3
Sarcoma 3.8
Breast 1.8
Non-Small Cell Lung 1.0
Bladder 1.0
Thyroid 1.0
Melanoma 0.8
Kidney 0.8
Hepatocellular 0.7
Non-Hodgkin Lymphoma 0.6
Testicular Germ Cell 0.4
Prostate 0.4
NOTE:
An off-panel tumor type, such as cholangiocarcinoma and esophageal adenocarcinoma, CANNOT BE EXCLUDED by the Test.
The following introduction is from the original report.
The Tissue of Origin Test, developed by Pathwork Diagnostics, measures the expression pattern, comprising more than 1500 genes, in a tumor to compare it to expression patterns of a panel of 15 known tumor types, representing 58 morphologies and covering 90% of all solid tumors. It produces a report with an objective score for each potential tissue (1,2). The test uses a proprietary Pathchip microarray and runs on the proven Affymetrix GeneChip System. According to the Pathwork Diagnostics, this test demonstrated 89% positive percent agreement (akin to sensitivity) with available diagnoses, and greater than 99% negative percent agreement (akin to specificity) in specimens that had previously been identified with existing methods as being among the 15 tumor types on the panel (3).
1. Dumur CI, Lyons-Weiler M, Sciulli C, et al. Interlaboratory performance of a microarray-based gene expression test to determine
tissue of origin in poorly differentiated and undifferentiated cancers. J Mol Diagn. 2008;10:67-77.
2. Monzon FA, Lyons-Weiler M, Buturovic LJ, et al. Multicenter validation of a 1,550-gene expression profile for identification of
tumor tissue of origin. J Clin Oncol. 2009;27:2503-8.
3. Pillai R, Deeter R, Rigl CT, et al. Validation and reproducibility of a microarray-based gene expression test for tumor
identification in formalin-fixed, paraffin-embedded specimens. J Mol Diagn. 2011;13:48-56.
引用 121 楼 cqzhao 在 2012-11-28 03:53:47 的发言:
Based on the requirement from the patient or clinician, the Tissue of Origin Test (from block) was performed by Pathwork Diagnostics (Redwood City, CA).
A. Most likely tissue of origin: PANCREAS (Degree of confidence: MODERATELY HIGH; Similarity Score-SS 41.6) (see note).
B. Tissues ruled out: Sarcoma, Breast, Non-Small Cell Lung, Bladder, Thyroid, Melanoma, Kidney, Hepatocellular, Hon-Hodgkin Lymphoma, Testicular Germ Cell, Prostate.
TISSUE OF ORIGIN TEST
TISSUE Similarity score:
Pancreas 41.6
Gastric 25.6
Colorectal 13.5
Ovarian 7.3
Sarcoma 3.8
Breast 1.8
Non-Small Cell Lung 1.0
Bladder 1.0
Thyroid 1.0
Melanoma 0.8
Kidney 0.8
Hepatocellular 0.7
Non-Hodgkin Lymphoma 0.6
Testicular Germ Cell 0.4
Prostate 0.4
NOTE:
An off-panel tumor type, such as cholangiocarcinoma and esophageal adenocarcinoma, CANNOT BE EXCLUDED by the Test.
Some one please help to translate the report about the tissue of origin test into chinese
