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- B2945Clinical and biological significance of E-cadherin protein expression in invasive lobular carcinom..
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Am J Surg Pathol. 2010 Oct;34(10):1472-9.
Clinical and biological significance of E-cadherin protein expression in invasive lobular carcinoma of the breast.
Rakha EA, Patel A, Powe DG, Benhasouna A, Green AR, Lambros MB, Reis-Filho JS, Ellis IO.
Department of Histopathology, Nottingham University Hospitals NHS Trust, UK. emadrakha@yahoo.com
Abstract
BACKGROUND: Although virtually all cases of lobular carcinoma in situ lack E-cadherin expression, a proportion of morphologically typical invasive lobular carcinomas (ILCs) retain its expression. The frequency and significance of E-cadherin expression in ILC remain to be elucidated. In this study, we have assessed E-cadherin protein expression in a well-characterized series of histologically defined ILC (239 cases) with a long-term clinical follow-up to determine the frequency, clinical and biological significance of its expression. E-cadherin-positive ILCs (ILC+) were subsequently examined to assess the expression of component members of the E-cadherin membrane complex (E-cadherin, p120, α, β, and γ-catenins) to determine its integrity.
RESULTS: Thirty-eight ILC cases (16%) showed positive E-cadherin expression (ILC+). Membranous expression of E-cadherin was mainly circumferential with frequent coexisting perimembranous cytoplasmic expression. No association between E-cadherin expression and any of the clinicopathologic variables, immunophenotype, or tumor behavior was identified, apart from an association with lobular histologic subtype and vascular invasion. Analysis of the E-cadherin-catenin complex showed abnormal expression of one or more of the catenin complex members in the majority of cases. The most frequent observation was the diffuse cytoplasmic expression of catenins, in particular p120, which showed similar expression to that reported in E-cadherin-negative ILCs.
CONCLUSIONS: These results provide evidence that E-cadherin is expressed in a proportion of ILC, however, unlike ductal carcinoma, its expression seems to be of limited significance and it is usually associated with evidence of impaired integrity of the E-cadherin-catenin membrane complex. Our data offer a possible explanation for the presence but lack functionality of E-cadherin in some cases of ILC and imply that immunohistochemical expression of E-cadherin per se in ILC histologic phenotypic tumors should not preclude its diagnosis.
PMID: 20871222 [PubMed - indexed for MEDLINE]
标签：乳腺浸润性小叶癌 E-cadherin p120
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本帖最后由 于 2010-11-28 08:16:00 编辑
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| 以下是引用cqzhao在2010-11-11 4:30:00的发言：
Above photos-E-cadherin: Authors interpretate D as invasive ductal ca only. Allother photos are invasive lobular ca. Do you agree?
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Authors interpretate F IDC, others ILC ? NOT D as IDC?
我觉得F是浸润性导管癌，CD是浸润性小叶癌，A看不清细胞特点不好判断，B如果是浸润性小叶癌则是多形性亚型，D可能不是浸润性小叶癌。
染色结果不容易理解。可能需要结合原切片的阳性、阴性对照考虑。
华夏病理/粉蓝医疗
为基层医院病理科提供全面解决方案，
努力让人人享有便捷准确可靠的病理诊断服务。
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本帖最后由 于 2010-11-28 07:03:00 编辑
Clinical and Biological Significance of E-cadherin Protein Expression in Invasive Lobular Carcinoma of the Breast (Am J Surg Pathol 2010;34:1472–1479)
Emad A. Rakha, FRCPath,* Arjun Patel, BSc,* Des G. Powe, PhD,* Ahmed Benhasouna, MSc,* Andrew R. Green, PhD,* Maryou B. Lambros, PhD, Jorge S. Reis-Filho, FRCPath, and Ian O. Ellis, FRCPath* (Nottingham)
Fellows Conference At Magee
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本帖最后由 于 2010-11-28 17:38:00 编辑
E-cadherin Function
For E-cadherin function in epithelial cell polarity and epithelial tissue integrity, the cytoplasmic tail of E-cadherin must be associated with cateninsa, b, and g-catenins and p120 Together these appear to play a role in signal transduction
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本帖最后由 于 2010-11-13 11:36:00 编辑
AbstractBACKGROUND: Although virtually all cases of lobular carcinoma in situ lack E-cadherin expression, a proportion of morphologically typical invasive lobular carcinomas (ILCs) retain its expression. The frequency and significance of E-cadherin expression in ILC remain to be elucidated. In this study, we have assessed E-cadherin protein expression in a well-characterized series of histologically defined ILC (239 cases) with a long-term clinical follow-up to determine the frequency, clinical and biological significance of its expression. E-cadherin-positive ILCs (ILC+) were subsequently examined to assess the expression of component members of the E-cadherin membrane complex (E-cadherin, p120, α, β, and γ-catenins) to determine its integrity.
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- there is no reason not to follow ur heart
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RESULTS: Thirty-eight ILC cases (16%) showed positive E-cadherin expression (ILC+). Membranous expression of E-cadherin was mainly circumferential with frequent coexisting perimembranous cytoplasmic expression. No association between E-cadherin expression and any of the clinicopathologic variables, immunophenotype, or tumor behavior was identified, apart from an association with lobular histologic subtype and vascular invasion. Analysis of the E-cadherin-catenin complex showed abnormal expression of one or more of the catenin complex members in the majority of cases. The most frequent observation was the diffuse cytoplasmic expression of catenins, in particular p120, which showed similar expression to that reported in E-cadherin-negative ILCs. CONCLUSIONS: These results provide evidence that E-cadherin is expressed in a proportion of ILC, however, unlike ductal carcinoma, its expression seems to be of limited significance and it is usually associated with evidence of impaired integrity of the E-cadherin-catenin membrane complex. Our data offer a possible explanation for the presence but lack functionality of E-cadherin in some cases of ILC and imply that immunohistochemical expression of E-cadherin per se in ILC histologic phenotypic tumors should not preclude its diagnosis. PMID: 20871222 [PubMed - indexed for MEDLINE] |
结果：38例(16%)ILC显示E-cadherin（+）（ILC+），E-cadherin 在细胞膜上的完整表达主要是通过膜周和胞质共存的来完成的，E-cadherin 的表达与临床病理学变量，免疫表型，或被确认的肿瘤生物学行为是没有任何联系的，除外小叶组织亚型和血管浸润两者间的联系。对E-cadherin-catenin 复合物的分析显示在大量病例中出现一个或多个catenin 复合物成分的异常表达，最常见的是catenin 弥散性的在胞质中表达，尤其是P120，在E-cadherin（-）的ILC中也出现相似的表达。
结论：这些结果显示E-cadherin在ILC中表达的比例，然而,不像导管癌,其表达似乎意义有限和它通常与E-cadherin-catenin膜复合物的完整性损伤有关，我们的数据现在为我们提供了一种可能性的解释，缺乏E-cadherin在部分ILC病例中的功能，同时提示在ILC的组织学表型中E-cadherin的免疫组化表达不影响诊断。
- there is no reason not to follow ur heart
