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12 楼 发表于2010-10-05 23:46:00举报|引用
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Although the architecture and cytology are both very suggestive, the diagnosis of bronchioloalveolar carcinoma cannot be made on a small specimen like this bronchoscopic biopsy (or fine needle aspiration/biopsy specimens) because by definition BAC has no stromal invasion and one can only tell this after histologic examination of the entire lesion (resected). Therefore the recommended diagnosis for such case is "adenocarcinoma (see comment)." And in the comment describe this possibility. Having seen many lung invasive adenocarcinoma with a BAC component makes me very reluctant to even suggest BAC based on small biopsies like this. More importantly is to perhaps check for KRAS mutations in malignant cells in this biopsy.
Although the architecture and cytology are both very suggestive, the diagnosis of bronchioloalveolar carcinoma cannot be made on a small specimen like this bronchoscopic biopsy (or fine needle aspiration/biopsy specimens) because by definition BAC has no stromal invasion and one can only tell this after histologic examination of the entire lesion (resected). Therefore the recommended diagnosis for such case is "adenocarcinoma (see comment)." And in the comment describe this possibility. Having seen many lung invasive adenocarcinoma with a BAC component makes me very reluctant to even suggest BAC based on small biopsies like this. More importantly is to perhaps check for KRAS mutations in malignant cells in this biopsy.
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