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I showed a case here a few days ago. It was a very complicated law-suit case and I cannot find more photos now. So I deleted it because it is not good for education.Sorry for that.(几天前我贴了一个病例在这里。那是一个非常复杂的法律诉讼病例,由于我没有更多的图片,对于教学不是很好所以我删除了它。为此我深感抱歉。)
Our fellow showed an interesting case. I put here for your review.(我们的住院医有一个很有趣的病案,我贴在这里一起分享)
42 y women with LMP 5 days ago and no previous Pap history (女性,42岁,末次月经5天前,既往无巴氏检查)
Type of Preparation: (制片类型)
Conventional(传统制片)
Magnification: (放大倍数)
High(高倍)
Interpretation: (判读)
Endocervical adenocarcinoma in situ(宫颈管原位腺癌)
Cytomorphologic Criteria: (细胞形态学标准)
Cluster of cells with enlarged, variably-sized round or oval nuclei with prominent nucleoli. A mitotic figure is also noted.(成团细胞增大,大小不等的圆形或卵圆形的核伴有突出的核仁。核分裂可见。)
Explanatory Notes: (注释)
AIS may occasionally show prominent nucleoli, raising the question of invasive endocervical adenocarcinoma.(宫颈管原位腺癌也可以出现突出的核仁,增加了浸润性颈管腺癌判读的问题)
Follow-up: (随访)
Endocervical adenocarcinoma in situ(宫颈管原位腺癌)
以上资料来自http://nih.techriver.net/view.php?patientId=100;请大家仔细看看这两团细胞有什么异同点。谢谢!
今天仔细的回头翻阅教科书和网上的修复的图片对照;发现跟赵老师发的图还是有明显的异同点:
1、修复的细胞团没有这么拥挤。
2、修复的细胞团没有这么稀少的胞浆和高核浆比。
3、修复的细胞团没有这样没有“方向感”(细胞缺少极性)。
4、共同点都有明显的核仁,同为平铺的2微结构。
总之,看了好多遍都没有给自己一个满意的解释,直接诊断AIS或腺癌又缺少能诊断的特征。但是又不能放在阴性,这就是我看这个片子的一种心态;正如有的病理专家说的:“只有写不出的诊断,没有写不出的报告”;如果是我的报告,会选择一个报一个AGC,建议宫颈管活检。
以下是引用追逐太阳在2010-4-23 7:13:00的发言:
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Above is excellent analysis. This is the way to learn from case study. Thnaks, cz
以下是引用青青子矜在2010-4-17 18:45:00的发言:
More history: patient had negative pap test one year ago. 难道赵老师是在提示我们:一年前是阴性而现在有病变?我怎么也看不出问题来啊,又没底啦 |
Just provide more information. Do not guess and make your judgment based on your knowledge and Pap information.
In fact I am not sure what the cell cluster represent.
以下是引用掌心0164在2010-4-19 21:54:00的发言:
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If all or most pathologists think it is negative, correct answer is negative.
If all or most pathologists think it is positive, correct answer is positive.
It is called standard care.
I do not know the correct answer and will let you know when I have.