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- B2421乳癌术后胸水检测 (cqz-29)
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60 y/f with history of breast ca and had segmental mastectomy sereral years ago in other hospital. Patient present with pleural effusion.
F1. ThinPrep 400x
F2. cell block 400x
F3-4. cell block 600x
What will you do?
标签：乳腺多形性小叶癌
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本帖最后由 于 2009-12-31 11:18:00 编辑
相关帖子
- • 右乳肿物诊断？
×参考诊断
（胸水）转移性乳腺多形性浸润性小叶癌，细胞学伴放化疗影响
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本帖最后由 于 2010-01-30 10:15:00 编辑
First step:
I always do some stains for these kinds of fluid cytologic cases to distinguish mesothelial cells from epithelial cells first.
Calretinin (mesothelial) and BerEP4 (epithelial)are the best two markers to choose.
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本帖最后由 于 2010-01-30 10:41:00 编辑
CK7 and CK20 are useful markers for unknown primary.
CK7+/CK20-: breast, gynecological, lung.
CK-/CK20+: GI (especially low GI)
TTF-1: relative specific for lung
ER: gyn and breast
This patient had history of breast ca. I added mammaglobin.
F1. CK7
F2. CK20
F3. Mammaglobin
TTF-1 negative
ER positive
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| 以下是引用cqzhao在2009-12-31 11:21:00的发言：
This is my last case in 2009. Thank all people who read and/or attended discussion for these cases. HAPPY NEW YEAR FOR ALL OF YOU. CZ |
HAPPY NEW YEAR TO YOU,Dr.Zhao.
这例在血细胞、炎症细胞的背景下，可见增生的间皮细胞。需要关注的是，极少的核膜增厚的染色质增粗的核仁增大的细胞，可能是问题细胞。建议利用细胞块做IHC标记D2-40、TTF-1等间皮与腺标记物，以鉴别。
- 王军臣
| 以下是引用笃行者在2010-1-1 21:19:00的发言：
对细胞学不是太熟悉，但感觉这些细胞核较大，核浆比增大，染色质较粗，核仁明显，有核分裂像，考虑是癌细胞。期待Dr.zhao解惑，谢谢！ HAPPY NEW YEAR TO YOU, Dr.Zhao. |
We sent message here in the same time. You just did a few second before me.
Happy New year to you too. Thank you I learned the new word "笃" in 2009. cz
