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- B2160浸润性导管癌伴大汗腺特征,morphology like histiocytoid or granular cell tumor (cqz-24) 7-16-2009
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本帖最后由 于 2009-08-15 20:06:00 编辑
Thank Abin for your contribution for this case. We signed out this biopsy case as invasive ductal carcinoma with apocrin feature. Apocrine ca is a subtype of ductal ca. Basically invasive apocrine ca and invasive usual ductal ca have similar prognosis.
As Abin mentioned classic IHC of apocrin ca: GCDFP-15+, BCL 2-, ER-, PR-.
Interesting part for this case is the morphologic features in breast core biopsy. The breast core bx specimen demonstrated the cytomorphologic features more like granular cell tumor, histiocytic lobular ca. The metastatic tumor in axillary lymph node has some features of apocrine tumor.
Thank all of you who read and attended the discussion for this case.
cz
abin译：
谢谢abin为本例的贡献。我们活检签发的是浸润性导管癌伴大汗腺特征。大汗腺癌是导管癌的一个亚型。浸润性大汗腺癌和浸润性导管癌有相似的预后。
正如abin提到的，大汗腺癌典型的免疫组化：GCDFP-15+, BCL 2-, ER-, PR-。
本例有趣之处在于，粗针穿刺活检时的形态学特征：细胞形态学特点更像颗粒细胞瘤和组织细胞样小叶癌。腋窝淋巴结转移肿瘤有大汗腺肿瘤的某些特征。
谢谢所有阅读并参与讨论的人。
cz
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本帖最后由 于 2009-08-03 20:47:00 编辑
Just complete today's cases. Feel released now. for this weekend night. I will tell you some IHC before I go to home.
Thank all of you for your very reasonable discusion.
AE1/AE3 strongly and diffusely positive.
F1 S-100
F2 CD68.
abin译：
刚完成今天的病例，觉得轻松了。在这周末之夜，在回家前，先告诉大家一些免疫组化结果。
谢谢所有参与讨论的人，你们的观点非常合理。
AE1/AE3 弥漫强阳性
图1 S-100
图2 CD68
名称：图1
描述：图1
名称：图2
描述：图2
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本帖最后由 于 2009-07-21 18:26:00 编辑
http://www.ipathology.cn/forum/forum_display.asp?keyno=147152
Is there any other differential dx
abin译：
请参考http://www.ipathology.cn/forum/forum_display.asp?keyno=147152（组织细胞样型乳腺癌looks like 颗粒细胞瘤 (cqz 17)）
是否有其他鉴别诊断？
