| 图片： | |
|---|---|
| 名称： | |
| 描述： | |
- B1739职工家属的宫内膜病变难住了我
图1
图2
图3
图4
图5
图6
图7
图8
图9
图10
图11
图12
图13
图14
图15
图16
图17
图18
图19
图20
图21
图22
图23
女 75岁
病史：绝经30年，阴道少量出血3天。乳腺癌术后2年余，口服他莫昔芬1年，现已停药1年余。
手术所见：宫腔深9厘米，宫内不平感，较硬。
彩超：宫腔内多个小结节，大的6*5毫米，无回声。
巨检：灰褐色碎组织一堆，共直径0.8厘米。
标签：子宫内膜 他莫昔芬
-
本帖最后由 于 2009-05-26 21:42:00 编辑
相关帖子
×参考诊断
宫内膜呈息肉样增生，部分腺上皮钉突样化生伴少数细胞增生异型
-
wangliunique 离线
- 帖子：2132
- 粉蓝豆：4
- 经验：2238
- 注册时间：2012-04-16
- 加关注 | 发消息
-
zezexiaozi 离线
- 帖子：16
- 粉蓝豆：60
- 经验：313
- 注册时间：2009-06-02
- 加关注 | 发消息
-
lantian0508 离线
- 帖子：1250
- 粉蓝豆：42
- 经验：1495
- 注册时间：2007-08-01
- 加关注 | 发消息
-
Check IHC figures. Ki67 showed increased proliferative index. Remember you will see a lot ki67 positivity if you stain proliferative endometrial glands. A few cells seems positive for p53 (nuclear stain). Morphology and IHC are not consistent with EIC (precursor of papillary serous ca), at least not like classic EIC. Standard care for EIC is hysterectomy plus staging.
Sorry I cannot paste the tables and figures. I can email you the paper if some ones are interested and cannot find the original paper.
This is the best paper about Arias-Stella Reaction written by Dr. avier Arias-Stella. He was a resident when he first described this findings.
The nature of the Arias-Stella reaction corresponds to
that of a long duration process—days, weeks, or
months—and as demonstrated above, it is accompanied
by the involvement of receptors and growth factors that
lead to DNA synthesis. Therefore, the evidence supports
the view that steroid action in the Arias-Stella reaction
follows, basically, the classic genomic path.
All of these findings suggest that the pathogenesis is
related to the effects of estrogen and progesterone acting
simultaneously, but as highlighted in the immunohistochemical
study, with a higher estrogen weighting than
found in the normal secretory phase. This imbalance
would be a determining factor, through intermediary
mechanisms, to induce the increased synthesis of DNA
that leads to the occurrence of polyploidism.
It is interesting to note that recently, the late Mexican
Professor Márquez-Monter et al. (69) compared the macronuclei
of the Arias-Stella reaction to those seen in
megaloblastic anemia, suggesting that in some cases,
they result from a change in the cellular cycle by mutation
of the “check point” bound to the mitogenic factor,
which determines the continuation of DNA synthesis. It
cannot be ruled out if in these hormonal interactions
there is a role for factors directly derived from chorionic
tissue.
CELL BIOLOGY
How do we locate this alteration from the perspective
of cell biology? The characteristics that we have highlighted
reveal an adaptive, controllable, and reversible
cellular reaction induced by hormonal actions that comprise
proliferative and antagonistic stimuli. Because the
cells that modify are mature cells that are not replaced, it
is not a form of metaplasia.
If the variability in the shape and size of the cells, the
pleomorphism and hyperchromasia, and the presence of
atypical mitosis could suggest dysplasia, the DNA polyploid
contents, absence of aneuploidy, and absence of
progression would not correspond with this process (Fig.
18, Table 15) (70).
At this level of knowledge, the accumulated information
leads us to think of a singular form of transdifferentiation:
conversion of a differentiated cell into another
differentiated cell. In this case it would be called “atypical
transdifferentiation” (Fig. 18).
This atypical transdifferentiation, which is characterized
by polyploidism, absence of aneuploidism, and absence
of progression of lesions, and which is found in
tissues that are sensitive to antagonistic hormonal factors,
would also occur in other areas, including atypical
cells in seminal vesicles (71,72); monstrous cells in epididymis
and duct deferens (73,74); atypical cells in lutein
cysts in pregnancy (27); atypical cells in luteinized
follicle cyst of pregnancy and puerperium (28); and bizarre,
benign cells in thyroid (dyshormogenetic goiter)
and other endocrine organs (75).
CONCLUSION
All of the above information allows us to conclude
that the description of endometrial atypia, associated
with the effect of the chorionic tissue, has had until now,
practical significance in gynecologic and obstetric pathology.
Owing to its peculiar relation to the synthesis of
DNA, it is possible that elucidating the pathogenesis of
the changes will have even greater importance in the
scope of cell biology. This is the challenge for future
generations.
REFERENCES
1. Arias-Stella J. Historia de un Epónimo Médico. Cuento para Estudiantes
de Medicina. To be published.
2. Arias-Stella J. Atypical endometrial changes associated with the
presence of chorionic tissue. Arch Pathol 1954;58:112–8.
3. Novak E. Surv Obstet Gynecol, p. 440 1–2, comments to
reference (1), 1955. 4. Carter D. Surgical pathology at Johns Hopkins. In: Rosai J, ed.
3. Novak E. Surv Obstet Gynecol, p. 440 1–2, comments to
reference (1), 1955. 4. Carter D. Surgical pathology at Johns Hopkins. In: Rosai J, ed.
reference (1), 1955.
4. Carter D. Surgical pathology at Johns Hopkins. In: Rosai J, ed.
Guiding the surgeon’s hand. the history of American surgical pathology.
Washington: American Registry of Pathology, 1997:34. 5. Arias-Stella J. Gestational endometrium. In: Norris HJ, Hertig AT, Abell MR, eds. The uterus. International Academy of Pathology,
monograph N-14. Baltimore: Williams & Wilkins, 1973:185–212. 6. Dorland’s Illustrated Medical Dictionary. ed 9. Madrid: McGraw- Hill–Interamericana de España, 1992. 7. Lloyd HED, Feinberg R. The Arias Stella reaction: a nonspecific involutional phenomenon in intra as well as extrauterine pregnancy. Am J Clin Pathol 1965;43:428–32.
8. Hendrickson MR, Longacre TA, Kempson RL. The uterine corpus. In: Sternberg SS, ed Diagnostic surgical pathology. 3rd ed. Philadelphia:
Lippincott Williams & Wilkins, 1999. 9. Mazur MT, Hendrickson MR, Kempson RL. Optically clear nuclei: an alteration of endometrial epithelium in the presence of trophoblast. Am J Surg Pathol 1983;7:415–23.
10. Dardi LE, Ariano L, Ariano MC, et al. Arias-Stella reaction with prominent nuclear pseudo inclusions simulating herpetic endometritis. 8. Hendrickson MR, Longacre TA, Kempson RL. The uterine corpus. In: Sternberg SS, ed Diagnostic surgical pathology. 3rd ed. Philadelphia:
Lippincott Williams & Wilkins, 1999. 9. Mazur MT, Hendrickson MR, Kempson RL. Optically clear nuclei: an alteration of endometrial epithelium in the presence of trophoblast. Am J Surg Pathol 1983;7:415–23.
10. Dardi LE, Ariano L, Ariano MC, et al. Arias-Stella reaction with prominent nuclear pseudo inclusions simulating herpetic endometritis. Lippincott Williams & Wilkins, 1999. 9. Mazur MT, Hendrickson MR, Kempson RL. Optically clear nuclei: an alteration of endometrial epithelium in the presence of trophoblast. Am J Surg Pathol 1983;7:415–23.
10. Dardi LE, Ariano L, Ariano MC, et al. Arias-Stella reaction with prominent nuclear pseudo inclusions simulating herpetic endometritis. 10. Dardi LE, Ariano L, Ariano MC, et al. Arias-Stella reaction with prominent nuclear pseudo inclusions simulating herpetic endometritis. Diagn Gynecol Obstet 1982;4:127–32.
11. Opitz E. Das Erkennen abgelaufener früher Schwanqerschaet an ausgeschabten Schleimhautbrockeln. Ztschr Gerburtsh Gynak 11. Opitz E. Das Erkennen abgelaufener früher Schwanqerschaet an ausgeschabten Schleimhautbrockeln. Ztschr Gerburtsh Gynak 1900;42:1–40, pl. 1–2. 12. Arias-Stella J. Atypical endometrial changes produced by chorionic tissue. Hum Pathol 1972;3:450–3.
13. Arias-Stella J, Jr., Arias-Velasquez, A, Arias-Stella J. Normal and abnormal mitoses in the atypical endometrial change associated with chorionic tissue effect. Am J Surg Pathol 1994;18:694–701.
14. de Brux J, Ancla M. Arias-Stella endometrial atypias case study with the electron microscope. Am J Obstet Gynecol 1964;89:
661–9. 15. Thasher TV, Richart RM. Ultrastructure of the Arias-Stella reaction. 13. Arias-Stella J, Jr., Arias-Velasquez, A, Arias-Stella J. Normal and abnormal mitoses in the atypical endometrial change associated with chorionic tissue effect. Am J Surg Pathol 1994;18:694–701.
14. de Brux J, Ancla M. Arias-Stella endometrial atypias case study with the electron microscope. Am J Obstet Gynecol 1964;89:
661–9. 15. Thasher TV, Richart RM. Ultrastructure of the Arias-Stella reaction. 14. de Brux J, Ancla M. Arias-Stella endometrial atypias case study with the electron microscope. Am J Obstet Gynecol 1964;89:
661–9. 15. Thasher TV, Richart RM. Ultrastructure of the Arias-Stella reaction. 661–9. 15. Thasher TV, Richart RM. Ultrastructure of the Arias-Stella reaction. Am J Obstet Gynecol 1972;112:113–20.
16. Salazar H, Burgess F. Correlaciones histológico ultrastructurales en la reacción endometrial de Arias Stella. VIII Congreso Latinoamericano de Patología. Programa, resumen, p. 41. Maracaibo 5–10, Dic. 1971. 17. Arias-Stella J, Gutiérrez J. Frecuencia y significado de las atipias endometriales en el embarazo ectópico. Rev Lat Am Anat Patol 16. Salazar H, Burgess F. Correlaciones histológico ultrastructurales en la reacción endometrial de Arias Stella. VIII Congreso Latinoamericano de Patología. Programa, resumen, p. 41. Maracaibo 5–10, Dic. 1971. 17. Arias-Stella J, Gutiérrez J. Frecuencia y significado de las atipias endometriales en el embarazo ectópico. Rev Lat Am Anat Patol 1957;1:81–91. 18. Arias-Stella J. A topographic study of uterine epithelial atypia associated with chorionic tissue: demonstration of alteration in the endocervix. Cancer 1959;12:782–90.
19. Moller NE. The Arias Stella phenomenon in endometriosis. Acta
Obstet Gynecol Scand 1959;38:271–4.
20. Cariani DJ, Guderian A. Gestational atypia in endocervical polyps: the Arias-Stella reaction. Am J Obstet Gynecol 1966;95:589–90.
21. McCormick CJ, Mennai-Williams RA. Tripolar mitotic figures occurring in an Arias-Stella reaction within an endocervical polyp. 19. Moller NE. The Arias Stella phenomenon in endometriosis. Acta
Obstet Gynecol Scand 1959;38:271–4.
20. Cariani DJ, Guderian A. Gestational atypia in endocervical polyps: the Arias-Stella reaction. Am J Obstet Gynecol 1966;95:589–90.
21. McCormick CJ, Mennai-Williams RA. Tripolar mitotic figures occurring in an Arias-Stella reaction within an endocervical polyp. Obstet Gynecol Scand 1959;38:271–4.
20. Cariani DJ, Guderian A. Gestational atypia in endocervical polyps: the Arias-Stella reaction. Am J Obstet Gynecol 1966;95:589–90.
21. McCormick CJ, Mennai-Williams RA. Tripolar mitotic figures occurring in an Arias-Stella reaction within an endocervical polyp. 20. Cariani DJ, Guderian A. Gestational atypia in endocervical polyps: the Arias-Stella reaction. Am J Obstet Gynecol 1966;95:589–90.
21. McCormick CJ, Mennai-Williams RA. Tripolar mitotic figures occurring in an Arias-Stella reaction within an endocervical polyp. 21. McCormick CJ, Mennai-Williams RA. Tripolar mitotic figures occurring in an Arias-Stella reaction within an endocervical polyp. Histopathology 1995;26:575–6.
22. Richmond H. Vaginal clear cell adenocarcinoma and adenosis in monozygotic twins [abstract] J Clin Pathol 1979;32 :416.
23. Jones WMD, Woodruff MD, Erlandson MD. Lewis JR. Desrelated clear adenocarcinoma of the vagina in pregnancy. Obstet
Gynecol 1981;57:765.
24. Blaustein A, Kantius M, Kaganowicz A, et al. Inclusions in ovaries of females aged day 1–30 years. Int J Gynecol Pathol 1982;1:
145–53. 25. Giltman LI. Modified Arias Stella reaction in paratubal epithelium. 22. Richmond H. Vaginal clear cell adenocarcinoma and adenosis in monozygotic twins [abstract] J Clin Pathol 1979;32 :416.
23. Jones WMD, Woodruff MD, Erlandson MD. Lewis JR. Desrelated clear adenocarcinoma of the vagina in pregnancy. Obstet
Gynecol 1981;57:765.
24. Blaustein A, Kantius M, Kaganowicz A, et al. Inclusions in ovaries of females aged day 1–30 years. Int J Gynecol Pathol 1982;1:
145–53. 25. Giltman LI. Modified Arias Stella reaction in paratubal epithelium. 23. Jones WMD, Woodruff MD, Erlandson MD. Lewis JR. Desrelated clear adenocarcinoma of the vagina in pregnancy. Obstet
Gynecol 1981;57:765.
24. Blaustein A, Kantius M, Kaganowicz A, et al. Inclusions in ovaries of females aged day 1–30 years. Int J Gynecol Pathol 1982;1:
145–53. 25. Giltman LI. Modified Arias Stella reaction in paratubal epithelium. Gynecol 1981;57:765.
24. Blaustein A, Kantius M, Kaganowicz A, et al. Inclusions in ovaries of females aged day 1–30 years. Int J Gynecol Pathol 1982;1:
145–53. 25. Giltman LI. Modified Arias Stella reaction in paratubal epithelium. 24. Blaustein A, Kantius M, Kaganowicz A, et al. Inclusions in ovaries of females aged day 1–30 years. Int J Gynecol Pathol 1982;1:
145–53. 25. Giltman LI. Modified Arias Stella reaction in paratubal epithelium. 145–53. 25. Giltman LI. Modified Arias Stella reaction in paratubal epithelium. Arch Gynecol 1986;237:243–5.
26. Spaun E, Toft B. Epithelial atypia in ovarian mucinous cystadenoma during the puerperium. Acta Obstet Gynecol Scand 1986;65:
505–6. 27. Albukerk JN, Berlin M. Unilateral lutein cyst in pregnancy. N Y
State J Med 1976;76:259–61.
28. Clement PB, Scully RE. Large solitary luteinized follicle cyst of pregnancy and puerperium. Am J Surg Pathol 1980;4:431–8.
29. Holmes DJ, Lyle WH. How early in pregnancy does the Arias- Stella reaction occur. Arch Pathol 1973;95:302–3.
30. Dahlerup A, Jorgensen VJ. The Arias-Stella phenomenon postpartum. In: Ohlsson H. Proceedings of the Tenth Scandinavian Congress
of Obstetrics and Gynecology. Lun, Sweden, 1958:76–84.
31. Oertel Y. The Arias-Stella reaction revisited. Arch Pathol Lab Med 26. Spaun E, Toft B. Epithelial atypia in ovarian mucinous cystadenoma during the puerperium. Acta Obstet Gynecol Scand 1986;65:
505–6. 27. Albukerk JN, Berlin M. Unilateral lutein cyst in pregnancy. N Y
State J Med 1976;76:259–61.
28. Clement PB, Scully RE. Large solitary luteinized follicle cyst of pregnancy and puerperium. Am J Surg Pathol 1980;4:431–8.
29. Holmes DJ, Lyle WH. How early in pregnancy does the Arias- Stella reaction occur. Arch Pathol 1973;95:302–3.
30. Dahlerup A, Jorgensen VJ. The Arias-Stella phenomenon postpartum. In: Ohlsson H. Proceedings of the Tenth Scandinavian Congress
of Obstetrics and Gynecology. Lun, Sweden, 1958:76–84.
31. Oertel Y. The Arias-Stella reaction revisited. Arch Pathol Lab Med 505–6. 27. Albukerk JN, Berlin M. Unilateral lutein cyst in pregnancy. N Y
State J Med 1976;76:259–61.
28. Clement PB, Scully RE. Large solitary luteinized follicle cyst of pregnancy and puerperium. Am J Surg Pathol 1980;4:431–8.
29. Holmes DJ, Lyle WH. How early in pregnancy does the Arias- Stella reaction occur. Arch Pathol 1973;95:302–3.
30. Dahlerup A, Jorgensen VJ. The Arias-Stella phenomenon postpartum. In: Ohlsson H. Proceedings of the Tenth Scandinavian Congress
of Obstetrics and Gynecology. Lun, Sweden, 1958:76–84.
31. Oertel Y. The Arias-Stella reaction revisited. Arch Pathol Lab Med State J Med 1976;76:259–61.
28. Clement PB, Scully RE. Large solitary luteinized follicle cyst of pregnancy and puerperium. Am J Surg Pathol 1980;4:431–8.
29. Holmes DJ, Lyle WH. How early in pregnancy does the Arias- Stella reaction occur. Arch Pathol 1973;95:302–3.
30. Dahlerup A, Jorgensen VJ. The Arias-Stella phenomenon postpartum. In: Ohlsson H. Proceedings of the Tenth Scandinavian Congress
of Obstetrics and Gynecology. Lun, Sweden, 1958:76–84.
31. Oertel Y. The Arias-Stella reaction revisited. Arch Pathol Lab Med 28. Clement PB, Scully RE. Large solitary luteinized follicle cyst of pregnancy and puerperium. Am J Surg Pathol 1980;4:431–8.
29. Holmes DJ, Lyle WH. How early in pregnancy does the Arias- Stella reaction occur. Arch Pathol 1973;95:302–3.
30. Dahlerup A, Jorgensen VJ. The Arias-Stella phenomenon postpartum. In: Ohlsson H. Proceedings of the Tenth Scandinavian Congress
of Obstetrics and Gynecology. Lun, Sweden, 1958:76–84.
31. Oertel Y. The Arias-Stella reaction revisited. Arch Pathol Lab Med 29. Holmes DJ, Lyle WH. How early in pregnancy does the Arias- Stella reaction occur. Arch Pathol 1973;95:302–3.
30. Dahlerup A, Jorgensen VJ. The Arias-Stella phenomenon postpartum. In: Ohlsson H. Proceedings of the Tenth Scandinavian Congress
of Obstetrics and Gynecology. Lun, Sweden, 1958:76–84.
31. Oertel Y. The Arias-Stella reaction revisited. Arch Pathol Lab Med 30. Dahlerup A, Jorgensen VJ. The Arias-Stella phenomenon postpartum. In: Ohlsson H. Proceedings of the Tenth Scandinavian Congress
of Obstetrics and Gynecology. Lun, Sweden, 1958:76–84.
31. Oertel Y. The Arias-Stella reaction revisited. Arch Pathol Lab Med of Obstetrics and Gynecology. Lun, Sweden, 1958:76–84.
31. Oertel Y. The Arias-Stella reaction revisited. Arch Pathol Lab Med 31. Oertel Y. The Arias-Stella reaction revisited. Arch Pathol Lab Med 1978;102:651–4. 32. Saavedra JA, Garcia-Miranda JL, Galera H, et al. The Arias Stella phenomenon and its diagnostic value in ectopic pregnancy: studies of 86 cases with review of literature [in German]. Zentralbl Gynakol 1975;97:1166–75. 33. Szadujkis-Lincel H. Arias-Stella reaction and its value in the diagnosis of ectopic pregnancy [in Polish]. Ginekol Pol 1970;41:
903–6. 34. Kurman R.J. Blaustein’s pathology of the female genital tract. 4th
edn. New York: Springer-Verlag, 1994. 35. Milchgrub SMD, Sandstad JMD. Arias Stella reaction in fallopian tube epithelium: a light and electron microscopic study with a review of the literature. Am J Clin Pathol 1991;95:892–5.
36. Schneider V. Arias-Stella reaction of the endocervix: frequency and location. Acta Cytol 1981;25:224–8.
37. Cove H. The Arias-Stella reaction occurring in the endocervix in pregnancy: recognition and comparison with adenocarcinoma of the endocervix. Am J Surg Pathol 1979;3:567–8.
38. Rhatigan RM. Endocervical gland atypia secondary to Arias-Stella change. Arch Pathol Lab Med 1992;116:943–6.
39. Cariani DJ, Guderian A. Gestational atypia in endocervical polyps: the Arias-Stella reaction. Am J Obstet Gynecol 1996;95:589–90.
40. McCormick CJ, Menai-Williams RA. Tripolar mitotic figures occurring in an Arias-Stella reaction within an endocervical polyp. 903–6. 34. Kurman R.J. Blaustein’s pathology of the female genital tract. 4th
edn. New York: Springer-Verlag, 1994. 35. Milchgrub SMD, Sandstad JMD. Arias Stella reaction in fallopian tube epithelium: a light and electron microscopic study with a review of the literature. Am J Clin Pathol 1991;95:892–5.
36. Schneider V. Arias-Stella reaction of the endocervix: frequency and location. Acta Cytol 1981;25:224–8.
37. Cove H. The Arias-Stella reaction occurring in the endocervix in pregnancy: recognition and comparison with adenocarcinoma of the endocervix. Am J Surg Pathol 1979;3:567–8.
38. Rhatigan RM. Endocervical gland atypia secondary to Arias-Stella change. Arch Pathol Lab Med 1992;116:943–6.
39. Cariani DJ, Guderian A. Gestational atypia in endocervical polyps: the Arias-Stella reaction. Am J Obstet Gynecol 1996;95:589–90.
40. McCormick CJ, Menai-Williams RA. Tripolar mitotic figures occurring in an Arias-Stella reaction within an endocervical polyp. edn. New York: Springer-Verlag, 1994. 35. Milchgrub SMD, Sandstad JMD. Arias Stella reaction in fallopian tube epithelium: a light and electron microscopic study with a review of the literature. Am J Clin Pathol 1991;95:892–5.
36. Schneider V. Arias-Stella reaction of the endocervix: frequency and location. Acta Cytol 1981;25:224–8.
37. Cove H. The Arias-Stella reaction occurring in the endocervix in pregnancy: recognition and comparison with adenocarcinoma of the endocervix. Am J Surg Pathol 1979;3:567–8.
38. Rhatigan RM. Endocervical gland atypia secondary to Arias-Stella change. Arch Pathol Lab Med 1992;116:943–6.
39. Cariani DJ, Guderian A. Gestational atypia in endocervical polyps: the Arias-Stella reaction. Am J Obstet Gynecol 1996;95:589–90.
40. McCormick CJ, Menai-Williams RA. Tripolar mitotic figures occurring in an Arias-Stella reaction within an endocervical polyp. 36. Schneider V. Arias-Stella reaction of the endocervix: frequency and location. Acta Cytol 1981;25:224–8.
37. Cove H. The Arias-Stella reaction occurring in the endocervix in pregnancy: recognition and comparison with adenocarcinoma of the endocervix. Am J Surg Pathol 1979;3:567–8.
38. Rhatigan RM. Endocervical gland atypia secondary to Arias-Stella change. Arch Pathol Lab Med 1992;116:943–6.
39. Cariani DJ, Guderian A. Gestational atypia in endocervical polyps: the Arias-Stella reaction. Am J Obstet Gynecol 1996;95:589–90.
40. McCormick CJ, Menai-Williams RA. Tripolar mitotic figures occurring in an Arias-Stella reaction within an endocervical polyp. 37. Cove H. The Arias-Stella reaction occurring in the endocervix in pregnancy: recognition and comparison with adenocarcinoma of the endocervix. Am J Surg Pathol 1979;3:567–8.
38. Rhatigan RM. Endocervical gland atypia secondary to Arias-Stella change. Arch Pathol Lab Med 1992;116:943–6.
39. Cariani DJ, Guderian A. Gestational atypia in endocervical polyps: the Arias-Stella reaction. Am J Obstet Gynecol 1996;95:589–90.
40. McCormick CJ, Menai-Williams RA. Tripolar mitotic figures occurring in an Arias-Stella reaction within an endocervical polyp. 38. Rhatigan RM. Endocervical gland atypia secondary to Arias-Stella change. Arch Pathol Lab Med 1992;116:943–6.
39. Cariani DJ, Guderian A. Gestational atypia in endocervical polyps: the Arias-Stella reaction. Am J Obstet Gynecol 1996;95:589–90.
40. McCormick CJ, Menai-Williams RA. Tripolar mitotic figures occurring in an Arias-Stella reaction within an endocervical polyp. 39. Cariani DJ, Guderian A. Gestational atypia in endocervical polyps: the Arias-Stella reaction. Am J Obstet Gynecol 1996;95:589–90.
40. McCormick CJ, Menai-Williams RA. Tripolar mitotic figures occurring in an Arias-Stella reaction within an endocervical polyp. 40. McCormick CJ, Menai-Williams RA. Tripolar mitotic figures occurring in an Arias-Stella reaction within an endocervical polyp. Histopathology 1995;26:575–6.
41. Hilrich NM, Hipke MM. Endometrial and cytologic atypism in the postabortal state. Obstet Gynecol 1955;6:452–4.
42. Albukerk JN. False-positive cytology in ectopic pregnancy N Engl
J Med 1974;291:1142.
43. Shrago SS. The Arias-Stella reaction: a case report of a cytologic presentation. Acta Cytol 1977;21:310–3.
44. Albukerk JN, Gnecco CA. Atypical cytology in tubal pregnancy. J
Reprod Med 1977;19:273–6.
45. Pisharodi LR, Jovanoska S. Spectrum of cytologic changes in pregnancy: a review of 100 abnormal cervicovaginal smears, with emphasis on diagnostic pitfalls. Acta Cytol 1995;39:905–8.
46. Mulvany NJ, Khan A, Ostor A. Arias-Stella reaction associated with cervical pregnancy: report of a case with a cytologic presentation. 41. Hilrich NM, Hipke MM. Endometrial and cytologic atypism in the postabortal state. Obstet Gynecol 1955;6:452–4.
42. Albukerk JN. False-positive cytology in ectopic pregnancy N Engl
J Med 1974;291:1142.
43. Shrago SS. The Arias-Stella reaction: a case report of a cytologic presentation. Acta Cytol 1977;21:310–3.
44. Albukerk JN, Gnecco CA. Atypical cytology in tubal pregnancy. J
Reprod Med 1977;19:273–6.
45. Pisharodi LR, Jovanoska S. Spectrum of cytologic changes in pregnancy: a review of 100 abnormal cervicovaginal smears, with emphasis on diagnostic pitfalls. Acta Cytol 1995;39:905–8.
46. Mulvany NJ, Khan A, Ostor A. Arias-Stella reaction associated with cervical pregnancy: report of a case with a cytologic presentation. 42. Albukerk JN. False-positive cytology in ectopic pregnancy N Engl
J Med 1974;291:1142.
43. Shrago SS. The Arias-Stella reaction: a case report of a cytologic presentation. Acta Cytol 1977;21:310–3.
44. Albukerk JN, Gnecco CA. Atypical cytology in tubal pregnancy. J
Reprod Med 1977;19:273–6.
45. Pisharodi LR, Jovanoska S. Spectrum of cytologic changes in pregnancy: a review of 100 abnormal cervicovaginal smears, with emphasis on diagnostic pitfalls. Acta Cytol 1995;39:905–8.
46. Mulvany NJ, Khan A, Ostor A. Arias-Stella reaction associated with cervical pregnancy: report of a case with a cytologic presentation. J Med 1974;291:1142.
43. Shrago SS. The Arias-Stella reaction: a case report of a cytologic presentation. Acta Cytol 1977;21:310–3.
44. Albukerk JN, Gnecco CA. Atypical cytology in tubal pregnancy. J
Reprod Med 1977;19:273–6.
45. Pisharodi LR, Jovanoska S. Spectrum of cytologic changes in pregnancy: a review of 100 abnormal cervicovaginal smears, with emphasis on diagnostic pitfalls. Acta Cytol 1995;39:905–8.
46. Mulvany NJ, Khan A, Ostor A. Arias-Stella reaction associated with cervical pregnancy: report of a case with a cytologic presentation. 43. Shrago SS. The Arias-Stella reaction: a case report of a cytologic presentation. Acta Cytol 1977;21:310–3.
44. Albukerk JN, Gnecco CA. Atypical cytology in tubal pregnancy. J
Reprod Med 1977;19:273–6.
45. Pisharodi LR, Jovanoska S. Spectrum of cytologic changes in pregnancy: a review of 100 abnormal cervicovaginal smears, with emphasis on diagnostic pitfalls. Acta Cytol 1995;39:905–8.
46. Mulvany NJ, Khan A, Ostor A. Arias-Stella reaction associated with cervical pregnancy: report of a case with a cytologic presentation. 44. Albukerk JN, Gnecco CA. Atypical cytology in tubal pregnancy. J
Reprod Med 1977;19:273–6.
45. Pisharodi LR, Jovanoska S. Spectrum of cytologic changes in pregnancy: a review of 100 abnormal cervicovaginal smears, with emphasis on diagnostic pitfalls. Acta Cytol 1995;39:905–8.
46. Mulvany NJ, Khan A, Ostor A. Arias-Stella reaction associated with cervical pregnancy: report of a case with a cytologic presentation. Reprod Med 1977;19:273–6.
45. Pisharodi LR, Jovanoska S. Spectrum of cytologic changes in pregnancy: a review of 100 abnormal cervicovaginal smears, with emphasis on diagnostic pitfalls. Acta Cytol 1995;39:905–8.
46. Mulvany NJ, Khan A, Ostor A. Arias-Stella reaction associated with cervical pregnancy: report of a case with a cytologic presentation. 45. Pisharodi LR, Jovanoska S. Spectrum of cytologic changes in pregnancy: a review of 100 abnormal cervicovaginal smears, with emphasis on diagnostic pitfalls. Acta Cytol 1995;39:905–8.
46. Mulvany NJ, Khan A, Ostor A. Arias-Stella reaction associated with cervical pregnancy: report of a case with a cytologic presentation. 46. Mulvany NJ, Khan A, Ostor A. Arias-Stella reaction associated with cervical pregnancy: report of a case with a cytologic presentation. Acta Cytol 1994;38:218–22.
47. Yates WA, Persad RV, Stanbridge CM. The Arias-Stella reaction in the cervix: a case report with cervical cytology. Cytopathology 47. Yates WA, Persad RV, Stanbridge CM. The Arias-Stella reaction in the cervix: a case report with cervical cytology. Cytopathology 1997;8:40–4. 48. Michael CW Esfahani FM, Pregnancy-related changes: a retrospective review of 278 cervical smears. Diagn Cytopathol 1997;
17:99–107. 49. Benoit JL, Kini SR. “Arias-Stella reaction”-like changes in endocervical glandular epithelium in cervical smears during pregnancy and postpartum states- a potential diagnostic pitfall. Diagn
Cytopathol 1966;14:349–55.
50. Chiara F. Le cellule poliploide nellendometrio umano. Ann Obstet
Gynecol 1960;82:1131–36.
51. Wagner D, Richart RM. Polyploidy in the human endometrium with the Arias-Stella reaction. Arch Pathol 1968;85:475–80.
52. Arias Stella J. Características, significación y patogenia de las alteraciones atípicas endometriales asociadas a la presencia de tejido coriónico. Anales de la Facultad de Medicina de la Universidad
Nac. Mayor de San Marcos de Lima 1960;42:523–46.
53. Silverberg SG. Arias Stella phenomenon in spontaneous and therapeutic abortion. Am J Obstet Gynecol 1982;112:777–80.
54. Velardo JT. Essentials of human reproduction. Oxford: Oxford University Press, 1958. 55. Schmidt-Matthiesen H. The normal endometrium. New York: Mc-
Graw-Hill,, 1963. 56. Arias-Stella J. Abnormal endometrial changes induced in the rat: the effects of chorionic hormone and estrogen. Arch Pathol 1955;
60:49–58. 57. Arias-Stella J. Endometrial changes in the rat: the effect of estrogen when administered after an interval following castration. Arch
Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413. 17:99–107. 49. Benoit JL, Kini SR. “Arias-Stella reaction”-like changes in endocervical glandular epithelium in cervical smears during pregnancy and postpartum states- a potential diagnostic pitfall. Diagn
Cytopathol 1966;14:349–55.
50. Chiara F. Le cellule poliploide nellendometrio umano. Ann Obstet
Gynecol 1960;82:1131–36.
51. Wagner D, Richart RM. Polyploidy in the human endometrium with the Arias-Stella reaction. Arch Pathol 1968;85:475–80.
52. Arias Stella J. Características, significación y patogenia de las alteraciones atípicas endometriales asociadas a la presencia de tejido coriónico. Anales de la Facultad de Medicina de la Universidad
Nac. Mayor de San Marcos de Lima 1960;42:523–46.
53. Silverberg SG. Arias Stella phenomenon in spontaneous and therapeutic abortion. Am J Obstet Gynecol 1982;112:777–80.
54. Velardo JT. Essentials of human reproduction. Oxford: Oxford University Press, 1958. 55. Schmidt-Matthiesen H. The normal endometrium. New York: Mc-
Graw-Hill,, 1963. 56. Arias-Stella J. Abnormal endometrial changes induced in the rat: the effects of chorionic hormone and estrogen. Arch Pathol 1955;
60:49–58. 57. Arias-Stella J. Endometrial changes in the rat: the effect of estrogen when administered after an interval following castration. Arch
Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413. Cytopathol 1966;14:349–55.
50. Chiara F. Le cellule poliploide nellendometrio umano. Ann Obstet
Gynecol 1960;82:1131–36.
51. Wagner D, Richart RM. Polyploidy in the human endometrium with the Arias-Stella reaction. Arch Pathol 1968;85:475–80.
52. Arias Stella J. Características, significación y patogenia de las alteraciones atípicas endometriales asociadas a la presencia de tejido coriónico. Anales de la Facultad de Medicina de la Universidad
Nac. Mayor de San Marcos de Lima 1960;42:523–46.
53. Silverberg SG. Arias Stella phenomenon in spontaneous and therapeutic abortion. Am J Obstet Gynecol 1982;112:777–80.
54. Velardo JT. Essentials of human reproduction. Oxford: Oxford University Press, 1958. 55. Schmidt-Matthiesen H. The normal endometrium. New York: Mc-
Graw-Hill,, 1963. 56. Arias-Stella J. Abnormal endometrial changes induced in the rat: the effects of chorionic hormone and estrogen. Arch Pathol 1955;
60:49–58. 57. Arias-Stella J. Endometrial changes in the rat: the effect of estrogen when administered after an interval following castration. Arch
Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413. 50. Chiara F. Le cellule poliploide nellendometrio umano. Ann Obstet
Gynecol 1960;82:1131–36.
51. Wagner D, Richart RM. Polyploidy in the human endometrium with the Arias-Stella reaction. Arch Pathol 1968;85:475–80.
52. Arias Stella J. Características, significación y patogenia de las alteraciones atípicas endometriales asociadas a la presencia de tejido coriónico. Anales de la Facultad de Medicina de la Universidad
Nac. Mayor de San Marcos de Lima 1960;42:523–46.
53. Silverberg SG. Arias Stella phenomenon in spontaneous and therapeutic abortion. Am J Obstet Gynecol 1982;112:777–80.
54. Velardo JT. Essentials of human reproduction. Oxford: Oxford University Press, 1958. 55. Schmidt-Matthiesen H. The normal endometrium. New York: Mc-
Graw-Hill,, 1963. 56. Arias-Stella J. Abnormal endometrial changes induced in the rat: the effects of chorionic hormone and estrogen. Arch Pathol 1955;
60:49–58. 57. Arias-Stella J. Endometrial changes in the rat: the effect of estrogen when administered after an interval following castration. Arch
Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413. Gynecol 1960;82:1131–36.
51. Wagner D, Richart RM. Polyploidy in the human endometrium with the Arias-Stella reaction. Arch Pathol 1968;85:475–80.
52. Arias Stella J. Características, significación y patogenia de las alteraciones atípicas endometriales asociadas a la presencia de tejido coriónico. Anales de la Facultad de Medicina de la Universidad
Nac. Mayor de San Marcos de Lima 1960;42:523–46.
53. Silverberg SG. Arias Stella phenomenon in spontaneous and therapeutic abortion. Am J Obstet Gynecol 1982;112:777–80.
54. Velardo JT. Essentials of human reproduction. Oxford: Oxford University Press, 1958. 55. Schmidt-Matthiesen H. The normal endometrium. New York: Mc-
Graw-Hill,, 1963. 56. Arias-Stella J. Abnormal endometrial changes induced in the rat: the effects of chorionic hormone and estrogen. Arch Pathol 1955;
60:49–58. 57. Arias-Stella J. Endometrial changes in the rat: the effect of estrogen when administered after an interval following castration. Arch
Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413. 51. Wagner D, Richart RM. Polyploidy in the human endometrium with the Arias-Stella reaction. Arch Pathol 1968;85:475–80.
52. Arias Stella J. Características, significación y patogenia de las alteraciones atípicas endometriales asociadas a la presencia de tejido coriónico. Anales de la Facultad de Medicina de la Universidad
Nac. Mayor de San Marcos de Lima 1960;42:523–46.
53. Silverberg SG. Arias Stella phenomenon in spontaneous and therapeutic abortion. Am J Obstet Gynecol 1982;112:777–80.
54. Velardo JT. Essentials of human reproduction. Oxford: Oxford University Press, 1958. 55. Schmidt-Matthiesen H. The normal endometrium. New York: Mc-
Graw-Hill,, 1963. 56. Arias-Stella J. Abnormal endometrial changes induced in the rat: the effects of chorionic hormone and estrogen. Arch Pathol 1955;
60:49–58. 57. Arias-Stella J. Endometrial changes in the rat: the effect of estrogen when administered after an interval following castration. Arch
Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413. 52. Arias Stella J. Características, significación y patogenia de las alteraciones atípicas endometriales asociadas a la presencia de tejido coriónico. Anales de la Facultad de Medicina de la Universidad
Nac. Mayor de San Marcos de Lima 1960;42:523–46.
53. Silverberg SG. Arias Stella phenomenon in spontaneous and therapeutic abortion. Am J Obstet Gynecol 1982;112:777–80.
54. Velardo JT. Essentials of human reproduction. Oxford: Oxford University Press, 1958. 55. Schmidt-Matthiesen H. The normal endometrium. New York: Mc-
Graw-Hill,, 1963. 56. Arias-Stella J. Abnormal endometrial changes induced in the rat: the effects of chorionic hormone and estrogen. Arch Pathol 1955;
60:49–58. 57. Arias-Stella J. Endometrial changes in the rat: the effect of estrogen when administered after an interval following castration. Arch
Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413. Nac. Mayor de San Marcos de Lima 1960;42:523–46.
53. Silverberg SG. Arias Stella phenomenon in spontaneous and therapeutic abortion. Am J Obstet Gynecol 1982;112:777–80.
54. Velardo JT. Essentials of human reproduction. Oxford: Oxford University Press, 1958. 55. Schmidt-Matthiesen H. The normal endometrium. New York: Mc-
Graw-Hill,, 1963. 56. Arias-Stella J. Abnormal endometrial changes induced in the rat: the effects of chorionic hormone and estrogen. Arch Pathol 1955;
60:49–58. 57. Arias-Stella J. Endometrial changes in the rat: the effect of estrogen when administered after an interval following castration. Arch
Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413. 53. Silverberg SG. Arias Stella phenomenon in spontaneous and therapeutic abortion. Am J Obstet Gynecol 1982;112:777–80.
54. Velardo JT. Essentials of human reproduction. Oxford: Oxford University Press, 1958. 55. Schmidt-Matthiesen H. The normal endometrium. New York: Mc-
Graw-Hill,, 1963. 56. Arias-Stella J. Abnormal endometrial changes induced in the rat: the effects of chorionic hormone and estrogen. Arch Pathol 1955;
60:49–58. 57. Arias-Stella J. Endometrial changes in the rat: the effect of estrogen when administered after an interval following castration. Arch
Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413. 54. Velardo JT. Essentials of human reproduction. Oxford: Oxford University Press, 1958. 55. Schmidt-Matthiesen H. The normal endometrium. New York: Mc-
Graw-Hill,, 1963. 56. Arias-Stella J. Abnormal endometrial changes induced in the rat: the effects of chorionic hormone and estrogen. Arch Pathol 1955;
60:49–58. 57. Arias-Stella J. Endometrial changes in the rat: the effect of estrogen when administered after an interval following castration. Arch
Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413. Graw-Hill,, 1963. 56. Arias-Stella J. Abnormal endometrial changes induced in the rat: the effects of chorionic hormone and estrogen. Arch Pathol 1955;
60:49–58. 57. Arias-Stella J. Endometrial changes in the rat: the effect of estrogen when administered after an interval following castration. Arch
Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413. 60:49–58. 57. Arias-Stella J. Endometrial changes in the rat: the effect of estrogen when administered after an interval following castration. Arch
Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413. Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413. 58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413. 59. Dockerty MB, Smith RA, Symmonds RE. Pseudomalignant endometrial changes induced by administration of new synthetic progestins. Proc Mayo Clin 1959;34:321–8.
60. Azzopardi JG, Zayid JG. Synthetic progestogen oestrogen therapy and uterine changes. J Clin Pathol 1967;20:731–7.
61. Huettner PC, Gersell DJ. Arias Stella reaction in nonpregnant women: a clinicopathologic study of nine cases. Int J Gynecol
Pathol 1994;13:241–7.
62. Good RG, Moyer DL. Estrogen-progesterone relationships in the development of secretory endometrium. Fertil Steril 1968;19:
37–49. 63. Hamilton TH, Teng CS, Means AR. Early estrogen action, nuclear synthesis and accumulation of protein correlated with enhancement of two DNA dependent RNA polymerase activities. Proc
Natl Acad Sci U S A 1968;59:1265–72.
64. Nordgvist S. The synthesis of DNA and RNA in normal human endometrium in short-term. incubation in vitro and its response to oestradiol and progesterone. J Endocrinol 1970;48:17–28.
65. O’Malley BW. Studies on the molecular mechanisms of steroid hormone action. The Harvey lecture. New York: Academic Press,
1978:53–90. 66. Allred DC, Harvey JM, Berardo M, et al. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod
Pathol 1998;11:155–68.
67. Doss BJ, Logani S, Jacques SM, et al The Arias Stella reaction and its variants: histopathologic and immunohistochemical features. 60. Azzopardi JG, Zayid JG. Synthetic progestogen oestrogen therapy and uterine changes. J Clin Pathol 1967;20:731–7.
61. Huettner PC, Gersell DJ. Arias Stella reaction in nonpregnant women: a clinicopathologic study of nine cases. Int J Gynecol
Pathol 1994;13:241–7.
62. Good RG, Moyer DL. Estrogen-progesterone relationships in the development of secretory endometrium. Fertil Steril 1968;19:
37–49. 63. Hamilton TH, Teng CS, Means AR. Early estrogen action, nuclear synthesis and accumulation of protein correlated with enhancement of two DNA dependent RNA polymerase activities. Proc
Natl Acad Sci U S A 1968;59:1265–72.
64. Nordgvist S. The synthesis of DNA and RNA in normal human endometrium in short-term. incubation in vitro and its response to oestradiol and progesterone. J Endocrinol 1970;48:17–28.
65. O’Malley BW. Studies on the molecular mechanisms of steroid hormone action. The Harvey lecture. New York: Academic Press,
1978:53–90. 66. Allred DC, Harvey JM, Berardo M, et al. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod
Pathol 1998;11:155–68.
67. Doss BJ, Logani S, Jacques SM, et al The Arias Stella reaction and its variants: histopathologic and immunohistochemical features. 61. Huettner PC, Gersell DJ. Arias Stella reaction in nonpregnant women: a clinicopathologic study of nine cases. Int J Gynecol
Pathol 1994;13:241–7.
62. Good RG, Moyer DL. Estrogen-progesterone relationships in the development of secretory endometrium. Fertil Steril 1968;19:
37–49. 63. Hamilton TH, Teng CS, Means AR. Early estrogen action, nuclear synthesis and accumulation of protein correlated with enhancement of two DNA dependent RNA polymerase activities. Proc
Natl Acad Sci U S A 1968;59:1265–72.
64. Nordgvist S. The synthesis of DNA and RNA in normal human endometrium in short-term. incubation in vitro and its response to oestradiol and progesterone. J Endocrinol 1970;48:17–28.
65. O’Malley BW. Studies on the molecular mechanisms of steroid hormone action. The Harvey lecture. New York: Academic Press,
1978:53–90. 66. Allred DC, Harvey JM, Berardo M, et al. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod
Pathol 1998;11:155–68.
67. Doss BJ, Logani S, Jacques SM, et al The Arias Stella reaction and its variants: histopathologic and immunohistochemical features. Pathol 1994;13:241–7.
62. Good RG, Moyer DL. Estrogen-progesterone relationships in the development of secretory endometrium. Fertil Steril 1968;19:
37–49. 63. Hamilton TH, Teng CS, Means AR. Early estrogen action, nuclear synthesis and accumulation of protein correlated with enhancement of two DNA dependent RNA polymerase activities. Proc
Natl Acad Sci U S A 1968;59:1265–72.
64. Nordgvist S. The synthesis of DNA and RNA in normal human endometrium in short-term. incubation in vitro and its response to oestradiol and progesterone. J Endocrinol 1970;48:17–28.
65. O’Malley BW. Studies on the molecular mechanisms of steroid hormone action. The Harvey lecture. New York: Academic Press,
1978:53–90. 66. Allred DC, Harvey JM, Berardo M, et al. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod
Pathol 1998;11:155–68.
67. Doss BJ, Logani S, Jacques SM, et al The Arias Stella reaction and its variants: histopathologic and immunohistochemical features. 62. Good RG, Moyer DL. Estrogen-progesterone relationships in the development of secretory endometrium. Fertil Steril 1968;19:
37–49. 63. Hamilton TH, Teng CS, Means AR. Early estrogen action, nuclear synthesis and accumulation of protein correlated with enhancement of two DNA dependent RNA polymerase activities. Proc
Natl Acad Sci U S A 1968;59:1265–72.
64. Nordgvist S. The synthesis of DNA and RNA in normal human endometrium in short-term. incubation in vitro and its response to oestradiol and progesterone. J Endocrinol 1970;48:17–28.
65. O’Malley BW. Studies on the molecular mechanisms of steroid hormone action. The Harvey lecture. New York: Academic Press,
1978:53–90. 66. Allred DC, Harvey JM, Berardo M, et al. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod
Pathol 1998;11:155–68.
67. Doss BJ, Logani S, Jacques SM, et al The Arias Stella reaction and its variants: histopathologic and immunohistochemical features. 37–49. 63. Hamilton TH, Teng CS, Means AR. Early estrogen action, nuclear synthesis and accumulation of protein correlated with enhancement of two DNA dependent RNA polymerase activities. Proc
Natl Acad Sci U S A 1968;59:1265–72.
64. Nordgvist S. The synthesis of DNA and RNA in normal human endometrium in short-term. incubation in vitro and its response to oestradiol and progesterone. J Endocrinol 1970;48:17–28.
65. O’Malley BW. Studies on the molecular mechanisms of steroid hormone action. The Harvey lecture. New York: Academic Press,
1978:53–90. 66. Allred DC, Harvey JM, Berardo M, et al. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod
Pathol 1998;11:155–68.
67. Doss BJ, Logani S, Jacques SM, et al The Arias Stella reaction and its variants: histopathologic and immunohistochemical features. Natl Acad Sci U S A 1968;59:1265–72.
64. Nordgvist S. The synthesis of DNA and RNA in normal human endometrium in short-term. incubation in vitro and its response to oestradiol and progesterone. J Endocrinol 1970;48:17–28.
65. O’Malley BW. Studies on the molecular mechanisms of steroid hormone action. The Harvey lecture. New York: Academic Press,
1978:53–90. 66. Allred DC, Harvey JM, Berardo M, et al. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod
Pathol 1998;11:155–68.
67. Doss BJ, Logani S, Jacques SM, et al The Arias Stella reaction and its variants: histopathologic and immunohistochemical features. 64. Nordgvist S. The synthesis of DNA and RNA in normal human endometrium in short-term. incubation in vitro and its response to oestradiol and progesterone. J Endocrinol 1970;48:17–28.
65. O’Malley BW. Studies on the molecular mechanisms of steroid hormone action. The Harvey lecture. New York: Academic Press,
1978:53–90. 66. Allred DC, Harvey JM, Berardo M, et al. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod
Pathol 1998;11:155–68.
67. Doss BJ, Logani S, Jacques SM, et al The Arias Stella reaction and its variants: histopathologic and immunohistochemical features. 65. O’Malley BW. Studies on the molecular mechanisms of steroid hormone action. The Harvey lecture. New York: Academic Press,
1978:53–90. 66. Allred DC, Harvey JM, Berardo M, et al. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod
Pathol 1998;11:155–68.
67. Doss BJ, Logani S, Jacques SM, et al The Arias Stella reaction and its variants: histopathologic and immunohistochemical features. 1978:53–90. 66. Allred DC, Harvey JM, Berardo M, et al. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod
Pathol 1998;11:155–68.
67. Doss BJ, Logani S, Jacques SM, et al The Arias Stella reaction and its variants: histopathologic and immunohistochemical features. Pathol 1998;11:155–68.
67. Doss BJ, Logani S, Jacques SM, et al The Arias Stella reaction and its variants: histopathologic and immunohistochemical features. 67. Doss BJ, Logani S, Jacques SM, et al The Arias Stella reaction and its variants: histopathologic and immunohistochemical features. Mod Pathol 1998;11:102a.
68. Revelli A, Massobrlo M, Tesarik J. Nongenomic actions of steroid hormones in reproductive tissues. Endocr Rev 1998;19: 3–17.
69. Márquez-Monter H, Estávez R, Cervantes M. Plausible explicación del fenómeno de Arias-Stella con base en el conocimiento del ciclo celular. Patología 1996;34:307–10.
70. Sambasiva Rao M, Reddy JK. Cell and tissue adaptations to injury. In: Sirica AE, ed. Cellular and molecular pathogenesis. Philadelphia:
Lippincott-Raven, 1996. 71. Peters H, Frank IM. The cytologic interpretation of the prostatic smear. Surg Gynecol Obstet 1952;94:69–76.
72. Arias-Stella J, Takano-Morón J. Atypical epithelial changes in the seminal vesicals. AMA. Arch Pathol 1958;66:761–6.
73. Kuo T, Gómez LG. Monstrous epithelial cells in human epididymis and seminal vesicles: a pseudomalignant change. Am J Surg
Pathol 1981;5:483–90.
74. Shah VI, Ro JY, Amin MB, et al. Histologic variations in the epididymis: findings in 167 orchiectomy specimens. Am J Surg
Pathol 1998;22:990–6.
75. Matos PS, Bisi M, Medeiros-Neto G. Dyshormonagenetic goiter: a morphologic and immunohistochemical study. Endocr Pathol 68. Revelli A, Massobrlo M, Tesarik J. Nongenomic actions of steroid hormones in reproductive tissues. Endocr Rev 1998;19: 3–17.
69. Márquez-Monter H, Estávez R, Cervantes M. Plausible explicación del fenómeno de Arias-Stella con base en el conocimiento del ciclo celular. Patología 1996;34:307–10.
70. Sambasiva Rao M, Reddy JK. Cell and tissue adaptations to injury. In: Sirica AE, ed. Cellular and molecular pathogenesis. Philadelphia:
Lippincott-Raven, 1996. 71. Peters H, Frank IM. The cytologic interpretation of the prostatic smear. Surg Gynecol Obstet 1952;94:69–76.
72. Arias-Stella J, Takano-Morón J. Atypical epithelial changes in the seminal vesicals. AMA. Arch Pathol 1958;66:761–6.
73. Kuo T, Gómez LG. Monstrous epithelial cells in human epididymis and seminal vesicles: a pseudomalignant change. Am J Surg
Pathol 1981;5:483–90.
74. Shah VI, Ro JY, Amin MB, et al. Histologic variations in the epididymis: findings in 167 orchiectomy specimens. Am J Surg
Pathol 1998;22:990–6.
75. Matos PS, Bisi M, Medeiros-Neto G. Dyshormonagenetic goiter: a morphologic and immunohistochemical study. Endocr Pathol 69. Márquez-Monter H, Estávez R, Cervantes M. Plausible explicación del fenómeno de Arias-Stella con base en el conocimiento del ciclo celular. Patología 1996;34:307–10.
70. Sambasiva Rao M, Reddy JK. Cell and tissue adaptations to injury. In: Sirica AE, ed. Cellular and molecular pathogenesis. Philadelphia:
Lippincott-Raven, 1996. 71. Peters H, Frank IM. The cytologic interpretation of the prostatic smear. Surg Gynecol Obstet 1952;94:69–76.
72. Arias-Stella J, Takano-Morón J. Atypical epithelial changes in the seminal vesicals. AMA. Arch Pathol 1958;66:761–6.
73. Kuo T, Gómez LG. Monstrous epithelial cells in human epididymis and seminal vesicles: a pseudomalignant change. Am J Surg
Pathol 1981;5:483–90.
74. Shah VI, Ro JY, Amin MB, et al. Histologic variations in the epididymis: findings in 167 orchiectomy specimens. Am J Surg
Pathol 1998;22:990–6.
75. Matos PS, Bisi M, Medeiros-Neto G. Dyshormonagenetic goiter: a morphologic and immunohistochemical study. Endocr Pathol 70. Sambasiva Rao M, Reddy JK. Cell and tissue adaptations to injury. In: Sirica AE, ed. Cellular and molecular pathogenesis. Philadelphia:
Lippincott-Raven, 1996. 71. Peters H, Frank IM. The cytologic interpretation of the prostatic smear. Surg Gynecol Obstet 1952;94:69–76.
72. Arias-Stella J, Takano-Morón J. Atypical epithelial changes in the seminal vesicals. AMA. Arch Pathol 1958;66:761–6.
73. Kuo T, Gómez LG. Monstrous epithelial cells in human epididymis and seminal vesicles: a pseudomalignant change. Am J Surg
Pathol 1981;5:483–90.
74. Shah VI, Ro JY, Amin MB, et al. Histologic variations in the epididymis: findings in 167 orchiectomy specimens. Am J Surg
Pathol 1998;22:990–6.
75. Matos PS, Bisi M, Medeiros-Neto G. Dyshormonagenetic goiter: a morphologic and immunohistochemical study. Endocr Pathol Lippincott-Raven, 1996. 71. Peters H, Frank IM. The cytologic interpretation of the prostatic smear. Surg Gynecol Obstet 1952;94:69–76.
72. Arias-Stella J, Takano-Morón J. Atypical epithelial changes in the seminal vesicals. AMA. Arch Pathol 1958;66:761–6.
73. Kuo T, Gómez LG. Monstrous epithelial cells in human epididymis and seminal vesicles: a pseudomalignant change. Am J Surg
Pathol 1981;5:483–90.
74. Shah VI, Ro JY, Amin MB, et al. Histologic variations in the epididymis: findings in 167 orchiectomy specimens. Am J Surg
Pathol 1998;22:990–6.
75. Matos PS, Bisi M, Medeiros-Neto G. Dyshormonagenetic goiter: a morphologic and immunohistochemical study. Endocr Pathol 72. Arias-Stella J, Takano-Morón J. Atypical epithelial changes in the seminal vesicals. AMA. Arch Pathol 1958;66:761–6.
73. Kuo T, Gómez LG. Monstrous epithelial cells in human epididymis and seminal vesicles: a pseudomalignant change. Am J Surg
Pathol 1981;5:483–90.
74. Shah VI, Ro JY, Amin MB, et al. Histologic variations in the epididymis: findings in 167 orchiectomy specimens. Am J Surg
Pathol 1998;22:990–6.
75. Matos PS, Bisi M, Medeiros-Neto G. Dyshormonagenetic goiter: a morphologic and immunohistochemical study. Endocr Pathol 73. Kuo T, Gómez LG. Monstrous epithelial cells in human epididymis and seminal vesicles: a pseudomalignant change. Am J Surg
Pathol 1981;5:483–90.
74. Shah VI, Ro JY, Amin MB, et al. Histologic variations in the epididymis: findings in 167 orchiectomy specimens. Am J Surg
Pathol 1998;22:990–6.
75. Matos PS, Bisi M, Medeiros-Neto G. Dyshormonagenetic goiter: a morphologic and immunohistochemical study. Endocr Pathol Pathol 1981;5:483–90.
74. Shah VI, Ro JY, Amin MB, et al. Histologic variations in the epididymis: findings in 167 orchiectomy specimens. Am J Surg
Pathol 1998;22:990–6.
75. Matos PS, Bisi M, Medeiros-Neto G. Dyshormonagenetic goiter: a morphologic and immunohistochemical study. Endocr Pathol 74. Shah VI, Ro JY, Amin MB, et al. Histologic variations in the epididymis: findings in 167 orchiectomy specimens. Am J Surg
Pathol 1998;22:990–6.
75. Matos PS, Bisi M, Medeiros-Neto G. Dyshormonagenetic goiter: a morphologic and immunohistochemical study. Endocr Pathol Pathol 1998;22:990–6.
75. Matos PS, Bisi M, Medeiros-Neto G. Dyshormonagenetic goiter: a morphologic and immunohistochemical study. Endocr Pathol 75. Matos PS, Bisi M, Medeiros-Neto G. Dyshormonagenetic goiter: a morphologic and immunohistochemical study. Endocr Pathol 1994;5:59–65.
Washington: American Registry of Pathology, 1997:34.
5. Arias-Stella J. Gestational endometrium. In: Norris HJ, Hertig AT,
Abell MR, eds. The uterus. International Academy of Pathology,
monograph N-14. Baltimore: Williams & Wilkins, 1973:185–212. 6. Dorland’s Illustrated Medical Dictionary. ed 9. Madrid: McGraw- Hill–Interamericana de España, 1992. 7. Lloyd HED, Feinberg R. The Arias Stella reaction: a nonspecific involutional phenomenon in intra as well as extrauterine pregnancy. Am J Clin Pathol 1965;43:428–32.
8. Hendrickson MR, Longacre TA, Kempson RL. The uterine corpus. In: Sternberg SS, ed Diagnostic surgical pathology. 3rd ed. Philadelphia:
Lippincott Williams & Wilkins, 1999. 9. Mazur MT, Hendrickson MR, Kempson RL. Optically clear nuclei: an alteration of endometrial epithelium in the presence of trophoblast. Am J Surg Pathol 1983;7:415–23.
10. Dardi LE, Ariano L, Ariano MC, et al. Arias-Stella reaction with prominent nuclear pseudo inclusions simulating herpetic endometritis. 8. Hendrickson MR, Longacre TA, Kempson RL. The uterine corpus. In: Sternberg SS, ed Diagnostic surgical pathology. 3rd ed. Philadelphia:
Lippincott Williams & Wilkins, 1999. 9. Mazur MT, Hendrickson MR, Kempson RL. Optically clear nuclei: an alteration of endometrial epithelium in the presence of trophoblast. Am J Surg Pathol 1983;7:415–23.
10. Dardi LE, Ariano L, Ariano MC, et al. Arias-Stella reaction with prominent nuclear pseudo inclusions simulating herpetic endometritis. Lippincott Williams & Wilkins, 1999. 9. Mazur MT, Hendrickson MR, Kempson RL. Optically clear nuclei: an alteration of endometrial epithelium in the presence of trophoblast. Am J Surg Pathol 1983;7:415–23.
10. Dardi LE, Ariano L, Ariano MC, et al. Arias-Stella reaction with prominent nuclear pseudo inclusions simulating herpetic endometritis. 10. Dardi LE, Ariano L, Ariano MC, et al. Arias-Stella reaction with prominent nuclear pseudo inclusions simulating herpetic endometritis. Diagn Gynecol Obstet 1982;4:127–32.
11. Opitz E. Das Erkennen abgelaufener früher Schwanqerschaet an ausgeschabten Schleimhautbrockeln. Ztschr Gerburtsh Gynak 11. Opitz E. Das Erkennen abgelaufener früher Schwanqerschaet an ausgeschabten Schleimhautbrockeln. Ztschr Gerburtsh Gynak 1900;42:1–40, pl. 1–2. 12. Arias-Stella J. Atypical endometrial changes produced by chorionic tissue. Hum Pathol 1972;3:450–3.
13. Arias-Stella J, Jr., Arias-Velasquez, A, Arias-Stella J. Normal and abnormal mitoses in the atypical endometrial change associated with chorionic tissue effect. Am J Surg Pathol 1994;18:694–701.
14. de Brux J, Ancla M. Arias-Stella endometrial atypias case study with the electron microscope. Am J Obstet Gynecol 1964;89:
661–9. 15. Thasher TV, Richart RM. Ultrastructure of the Arias-Stella reaction. 13. Arias-Stella J, Jr., Arias-Velasquez, A, Arias-Stella J. Normal and abnormal mitoses in the atypical endometrial change associated with chorionic tissue effect. Am J Surg Pathol 1994;18:694–701.
14. de Brux J, Ancla M. Arias-Stella endometrial atypias case study with the electron microscope. Am J Obstet Gynecol 1964;89:
661–9. 15. Thasher TV, Richart RM. Ultrastructure of the Arias-Stella reaction. 14. de Brux J, Ancla M. Arias-Stella endometrial atypias case study with the electron microscope. Am J Obstet Gynecol 1964;89:
661–9. 15. Thasher TV, Richart RM. Ultrastructure of the Arias-Stella reaction. 661–9. 15. Thasher TV, Richart RM. Ultrastructure of the Arias-Stella reaction. Am J Obstet Gynecol 1972;112:113–20.
16. Salazar H, Burgess F. Correlaciones histológico ultrastructurales en la reacción endometrial de Arias Stella. VIII Congreso Latinoamericano de Patología. Programa, resumen, p. 41. Maracaibo 5–10, Dic. 1971. 17. Arias-Stella J, Gutiérrez J. Frecuencia y significado de las atipias endometriales en el embarazo ectópico. Rev Lat Am Anat Patol 16. Salazar H, Burgess F. Correlaciones histológico ultrastructurales en la reacción endometrial de Arias Stella. VIII Congreso Latinoamericano de Patología. Programa, resumen, p. 41. Maracaibo 5–10, Dic. 1971. 17. Arias-Stella J, Gutiérrez J. Frecuencia y significado de las atipias endometriales en el embarazo ectópico. Rev Lat Am Anat Patol 1957;1:81–91. 18. Arias-Stella J. A topographic study of uterine epithelial atypia associated with chorionic tissue: demonstration of alteration in the endocervix. Cancer 1959;12:782–90.
19. Moller NE. The Arias Stella phenomenon in endometriosis. Acta
Obstet Gynecol Scand 1959;38:271–4.
20. Cariani DJ, Guderian A. Gestational atypia in endocervical polyps: the Arias-Stella reaction. Am J Obstet Gynecol 1966;95:589–90.
21. McCormick CJ, Mennai-Williams RA. Tripolar mitotic figures occurring in an Arias-Stella reaction within an endocervical polyp. 19. Moller NE. The Arias Stella phenomenon in endometriosis. Acta
Obstet Gynecol Scand 1959;38:271–4.
20. Cariani DJ, Guderian A. Gestational atypia in endocervical polyps: the Arias-Stella reaction. Am J Obstet Gynecol 1966;95:589–90.
21. McCormick CJ, Mennai-Williams RA. Tripolar mitotic figures occurring in an Arias-Stella reaction within an endocervical polyp. Obstet Gynecol Scand 1959;38:271–4.
20. Cariani DJ, Guderian A. Gestational atypia in endocervical polyps: the Arias-Stella reaction. Am J Obstet Gynecol 1966;95:589–90.
21. McCormick CJ, Mennai-Williams RA. Tripolar mitotic figures occurring in an Arias-Stella reaction within an endocervical polyp. 20. Cariani DJ, Guderian A. Gestational atypia in endocervical polyps: the Arias-Stella reaction. Am J Obstet Gynecol 1966;95:589–90.
21. McCormick CJ, Mennai-Williams RA. Tripolar mitotic figures occurring in an Arias-Stella reaction within an endocervical polyp. 21. McCormick CJ, Mennai-Williams RA. Tripolar mitotic figures occurring in an Arias-Stella reaction within an endocervical polyp. Histopathology 1995;26:575–6.
22. Richmond H. Vaginal clear cell adenocarcinoma and adenosis in monozygotic twins [abstract] J Clin Pathol 1979;32 :416.
23. Jones WMD, Woodruff MD, Erlandson MD. Lewis JR. Desrelated clear adenocarcinoma of the vagina in pregnancy. Obstet
Gynecol 1981;57:765.
24. Blaustein A, Kantius M, Kaganowicz A, et al. Inclusions in ovaries of females aged day 1–30 years. Int J Gynecol Pathol 1982;1:
145–53. 25. Giltman LI. Modified Arias Stella reaction in paratubal epithelium. 22. Richmond H. Vaginal clear cell adenocarcinoma and adenosis in monozygotic twins [abstract] J Clin Pathol 1979;32 :416.
23. Jones WMD, Woodruff MD, Erlandson MD. Lewis JR. Desrelated clear adenocarcinoma of the vagina in pregnancy. Obstet
Gynecol 1981;57:765.
24. Blaustein A, Kantius M, Kaganowicz A, et al. Inclusions in ovaries of females aged day 1–30 years. Int J Gynecol Pathol 1982;1:
145–53. 25. Giltman LI. Modified Arias Stella reaction in paratubal epithelium. 23. Jones WMD, Woodruff MD, Erlandson MD. Lewis JR. Desrelated clear adenocarcinoma of the vagina in pregnancy. Obstet
Gynecol 1981;57:765.
24. Blaustein A, Kantius M, Kaganowicz A, et al. Inclusions in ovaries of females aged day 1–30 years. Int J Gynecol Pathol 1982;1:
145–53. 25. Giltman LI. Modified Arias Stella reaction in paratubal epithelium. Gynecol 1981;57:765.
24. Blaustein A, Kantius M, Kaganowicz A, et al. Inclusions in ovaries of females aged day 1–30 years. Int J Gynecol Pathol 1982;1:
145–53. 25. Giltman LI. Modified Arias Stella reaction in paratubal epithelium. 24. Blaustein A, Kantius M, Kaganowicz A, et al. Inclusions in ovaries of females aged day 1–30 years. Int J Gynecol Pathol 1982;1:
145–53. 25. Giltman LI. Modified Arias Stella reaction in paratubal epithelium. 145–53. 25. Giltman LI. Modified Arias Stella reaction in paratubal epithelium. Arch Gynecol 1986;237:243–5.
26. Spaun E, Toft B. Epithelial atypia in ovarian mucinous cystadenoma during the puerperium. Acta Obstet Gynecol Scand 1986;65:
505–6. 27. Albukerk JN, Berlin M. Unilateral lutein cyst in pregnancy. N Y
State J Med 1976;76:259–61.
28. Clement PB, Scully RE. Large solitary luteinized follicle cyst of pregnancy and puerperium. Am J Surg Pathol 1980;4:431–8.
29. Holmes DJ, Lyle WH. How early in pregnancy does the Arias- Stella reaction occur. Arch Pathol 1973;95:302–3.
30. Dahlerup A, Jorgensen VJ. The Arias-Stella phenomenon postpartum. In: Ohlsson H. Proceedings of the Tenth Scandinavian Congress
of Obstetrics and Gynecology. Lun, Sweden, 1958:76–84.
31. Oertel Y. The Arias-Stella reaction revisited. Arch Pathol Lab Med 26. Spaun E, Toft B. Epithelial atypia in ovarian mucinous cystadenoma during the puerperium. Acta Obstet Gynecol Scand 1986;65:
505–6. 27. Albukerk JN, Berlin M. Unilateral lutein cyst in pregnancy. N Y
State J Med 1976;76:259–61.
28. Clement PB, Scully RE. Large solitary luteinized follicle cyst of pregnancy and puerperium. Am J Surg Pathol 1980;4:431–8.
29. Holmes DJ, Lyle WH. How early in pregnancy does the Arias- Stella reaction occur. Arch Pathol 1973;95:302–3.
30. Dahlerup A, Jorgensen VJ. The Arias-Stella phenomenon postpartum. In: Ohlsson H. Proceedings of the Tenth Scandinavian Congress
of Obstetrics and Gynecology. Lun, Sweden, 1958:76–84.
31. Oertel Y. The Arias-Stella reaction revisited. Arch Pathol Lab Med 505–6. 27. Albukerk JN, Berlin M. Unilateral lutein cyst in pregnancy. N Y
State J Med 1976;76:259–61.
28. Clement PB, Scully RE. Large solitary luteinized follicle cyst of pregnancy and puerperium. Am J Surg Pathol 1980;4:431–8.
29. Holmes DJ, Lyle WH. How early in pregnancy does the Arias- Stella reaction occur. Arch Pathol 1973;95:302–3.
30. Dahlerup A, Jorgensen VJ. The Arias-Stella phenomenon postpartum. In: Ohlsson H. Proceedings of the Tenth Scandinavian Congress
of Obstetrics and Gynecology. Lun, Sweden, 1958:76–84.
31. Oertel Y. The Arias-Stella reaction revisited. Arch Pathol Lab Med State J Med 1976;76:259–61.
28. Clement PB, Scully RE. Large solitary luteinized follicle cyst of pregnancy and puerperium. Am J Surg Pathol 1980;4:431–8.
29. Holmes DJ, Lyle WH. How early in pregnancy does the Arias- Stella reaction occur. Arch Pathol 1973;95:302–3.
30. Dahlerup A, Jorgensen VJ. The Arias-Stella phenomenon postpartum. In: Ohlsson H. Proceedings of the Tenth Scandinavian Congress
of Obstetrics and Gynecology. Lun, Sweden, 1958:76–84.
31. Oertel Y. The Arias-Stella reaction revisited. Arch Pathol Lab Med 28. Clement PB, Scully RE. Large solitary luteinized follicle cyst of pregnancy and puerperium. Am J Surg Pathol 1980;4:431–8.
29. Holmes DJ, Lyle WH. How early in pregnancy does the Arias- Stella reaction occur. Arch Pathol 1973;95:302–3.
30. Dahlerup A, Jorgensen VJ. The Arias-Stella phenomenon postpartum. In: Ohlsson H. Proceedings of the Tenth Scandinavian Congress
of Obstetrics and Gynecology. Lun, Sweden, 1958:76–84.
31. Oertel Y. The Arias-Stella reaction revisited. Arch Pathol Lab Med 29. Holmes DJ, Lyle WH. How early in pregnancy does the Arias- Stella reaction occur. Arch Pathol 1973;95:302–3.
30. Dahlerup A, Jorgensen VJ. The Arias-Stella phenomenon postpartum. In: Ohlsson H. Proceedings of the Tenth Scandinavian Congress
of Obstetrics and Gynecology. Lun, Sweden, 1958:76–84.
31. Oertel Y. The Arias-Stella reaction revisited. Arch Pathol Lab Med 30. Dahlerup A, Jorgensen VJ. The Arias-Stella phenomenon postpartum. In: Ohlsson H. Proceedings of the Tenth Scandinavian Congress
of Obstetrics and Gynecology. Lun, Sweden, 1958:76–84.
31. Oertel Y. The Arias-Stella reaction revisited. Arch Pathol Lab Med of Obstetrics and Gynecology. Lun, Sweden, 1958:76–84.
31. Oertel Y. The Arias-Stella reaction revisited. Arch Pathol Lab Med 31. Oertel Y. The Arias-Stella reaction revisited. Arch Pathol Lab Med 1978;102:651–4. 32. Saavedra JA, Garcia-Miranda JL, Galera H, et al. The Arias Stella phenomenon and its diagnostic value in ectopic pregnancy: studies of 86 cases with review of literature [in German]. Zentralbl Gynakol 1975;97:1166–75. 33. Szadujkis-Lincel H. Arias-Stella reaction and its value in the diagnosis of ectopic pregnancy [in Polish]. Ginekol Pol 1970;41:
903–6. 34. Kurman R.J. Blaustein’s pathology of the female genital tract. 4th
edn. New York: Springer-Verlag, 1994. 35. Milchgrub SMD, Sandstad JMD. Arias Stella reaction in fallopian tube epithelium: a light and electron microscopic study with a review of the literature. Am J Clin Pathol 1991;95:892–5.
36. Schneider V. Arias-Stella reaction of the endocervix: frequency and location. Acta Cytol 1981;25:224–8.
37. Cove H. The Arias-Stella reaction occurring in the endocervix in pregnancy: recognition and comparison with adenocarcinoma of the endocervix. Am J Surg Pathol 1979;3:567–8.
38. Rhatigan RM. Endocervical gland atypia secondary to Arias-Stella change. Arch Pathol Lab Med 1992;116:943–6.
39. Cariani DJ, Guderian A. Gestational atypia in endocervical polyps: the Arias-Stella reaction. Am J Obstet Gynecol 1996;95:589–90.
40. McCormick CJ, Menai-Williams RA. Tripolar mitotic figures occurring in an Arias-Stella reaction within an endocervical polyp. 903–6. 34. Kurman R.J. Blaustein’s pathology of the female genital tract. 4th
edn. New York: Springer-Verlag, 1994. 35. Milchgrub SMD, Sandstad JMD. Arias Stella reaction in fallopian tube epithelium: a light and electron microscopic study with a review of the literature. Am J Clin Pathol 1991;95:892–5.
36. Schneider V. Arias-Stella reaction of the endocervix: frequency and location. Acta Cytol 1981;25:224–8.
37. Cove H. The Arias-Stella reaction occurring in the endocervix in pregnancy: recognition and comparison with adenocarcinoma of the endocervix. Am J Surg Pathol 1979;3:567–8.
38. Rhatigan RM. Endocervical gland atypia secondary to Arias-Stella change. Arch Pathol Lab Med 1992;116:943–6.
39. Cariani DJ, Guderian A. Gestational atypia in endocervical polyps: the Arias-Stella reaction. Am J Obstet Gynecol 1996;95:589–90.
40. McCormick CJ, Menai-Williams RA. Tripolar mitotic figures occurring in an Arias-Stella reaction within an endocervical polyp. edn. New York: Springer-Verlag, 1994. 35. Milchgrub SMD, Sandstad JMD. Arias Stella reaction in fallopian tube epithelium: a light and electron microscopic study with a review of the literature. Am J Clin Pathol 1991;95:892–5.
36. Schneider V. Arias-Stella reaction of the endocervix: frequency and location. Acta Cytol 1981;25:224–8.
37. Cove H. The Arias-Stella reaction occurring in the endocervix in pregnancy: recognition and comparison with adenocarcinoma of the endocervix. Am J Surg Pathol 1979;3:567–8.
38. Rhatigan RM. Endocervical gland atypia secondary to Arias-Stella change. Arch Pathol Lab Med 1992;116:943–6.
39. Cariani DJ, Guderian A. Gestational atypia in endocervical polyps: the Arias-Stella reaction. Am J Obstet Gynecol 1996;95:589–90.
40. McCormick CJ, Menai-Williams RA. Tripolar mitotic figures occurring in an Arias-Stella reaction within an endocervical polyp. 36. Schneider V. Arias-Stella reaction of the endocervix: frequency and location. Acta Cytol 1981;25:224–8.
37. Cove H. The Arias-Stella reaction occurring in the endocervix in pregnancy: recognition and comparison with adenocarcinoma of the endocervix. Am J Surg Pathol 1979;3:567–8.
38. Rhatigan RM. Endocervical gland atypia secondary to Arias-Stella change. Arch Pathol Lab Med 1992;116:943–6.
39. Cariani DJ, Guderian A. Gestational atypia in endocervical polyps: the Arias-Stella reaction. Am J Obstet Gynecol 1996;95:589–90.
40. McCormick CJ, Menai-Williams RA. Tripolar mitotic figures occurring in an Arias-Stella reaction within an endocervical polyp. 37. Cove H. The Arias-Stella reaction occurring in the endocervix in pregnancy: recognition and comparison with adenocarcinoma of the endocervix. Am J Surg Pathol 1979;3:567–8.
38. Rhatigan RM. Endocervical gland atypia secondary to Arias-Stella change. Arch Pathol Lab Med 1992;116:943–6.
39. Cariani DJ, Guderian A. Gestational atypia in endocervical polyps: the Arias-Stella reaction. Am J Obstet Gynecol 1996;95:589–90.
40. McCormick CJ, Menai-Williams RA. Tripolar mitotic figures occurring in an Arias-Stella reaction within an endocervical polyp. 38. Rhatigan RM. Endocervical gland atypia secondary to Arias-Stella change. Arch Pathol Lab Med 1992;116:943–6.
39. Cariani DJ, Guderian A. Gestational atypia in endocervical polyps: the Arias-Stella reaction. Am J Obstet Gynecol 1996;95:589–90.
40. McCormick CJ, Menai-Williams RA. Tripolar mitotic figures occurring in an Arias-Stella reaction within an endocervical polyp. 39. Cariani DJ, Guderian A. Gestational atypia in endocervical polyps: the Arias-Stella reaction. Am J Obstet Gynecol 1996;95:589–90.
40. McCormick CJ, Menai-Williams RA. Tripolar mitotic figures occurring in an Arias-Stella reaction within an endocervical polyp. 40. McCormick CJ, Menai-Williams RA. Tripolar mitotic figures occurring in an Arias-Stella reaction within an endocervical polyp. Histopathology 1995;26:575–6.
41. Hilrich NM, Hipke MM. Endometrial and cytologic atypism in the postabortal state. Obstet Gynecol 1955;6:452–4.
42. Albukerk JN. False-positive cytology in ectopic pregnancy N Engl
J Med 1974;291:1142.
43. Shrago SS. The Arias-Stella reaction: a case report of a cytologic presentation. Acta Cytol 1977;21:310–3.
44. Albukerk JN, Gnecco CA. Atypical cytology in tubal pregnancy. J
Reprod Med 1977;19:273–6.
45. Pisharodi LR, Jovanoska S. Spectrum of cytologic changes in pregnancy: a review of 100 abnormal cervicovaginal smears, with emphasis on diagnostic pitfalls. Acta Cytol 1995;39:905–8.
46. Mulvany NJ, Khan A, Ostor A. Arias-Stella reaction associated with cervical pregnancy: report of a case with a cytologic presentation. 41. Hilrich NM, Hipke MM. Endometrial and cytologic atypism in the postabortal state. Obstet Gynecol 1955;6:452–4.
42. Albukerk JN. False-positive cytology in ectopic pregnancy N Engl
J Med 1974;291:1142.
43. Shrago SS. The Arias-Stella reaction: a case report of a cytologic presentation. Acta Cytol 1977;21:310–3.
44. Albukerk JN, Gnecco CA. Atypical cytology in tubal pregnancy. J
Reprod Med 1977;19:273–6.
45. Pisharodi LR, Jovanoska S. Spectrum of cytologic changes in pregnancy: a review of 100 abnormal cervicovaginal smears, with emphasis on diagnostic pitfalls. Acta Cytol 1995;39:905–8.
46. Mulvany NJ, Khan A, Ostor A. Arias-Stella reaction associated with cervical pregnancy: report of a case with a cytologic presentation. 42. Albukerk JN. False-positive cytology in ectopic pregnancy N Engl
J Med 1974;291:1142.
43. Shrago SS. The Arias-Stella reaction: a case report of a cytologic presentation. Acta Cytol 1977;21:310–3.
44. Albukerk JN, Gnecco CA. Atypical cytology in tubal pregnancy. J
Reprod Med 1977;19:273–6.
45. Pisharodi LR, Jovanoska S. Spectrum of cytologic changes in pregnancy: a review of 100 abnormal cervicovaginal smears, with emphasis on diagnostic pitfalls. Acta Cytol 1995;39:905–8.
46. Mulvany NJ, Khan A, Ostor A. Arias-Stella reaction associated with cervical pregnancy: report of a case with a cytologic presentation. J Med 1974;291:1142.
43. Shrago SS. The Arias-Stella reaction: a case report of a cytologic presentation. Acta Cytol 1977;21:310–3.
44. Albukerk JN, Gnecco CA. Atypical cytology in tubal pregnancy. J
Reprod Med 1977;19:273–6.
45. Pisharodi LR, Jovanoska S. Spectrum of cytologic changes in pregnancy: a review of 100 abnormal cervicovaginal smears, with emphasis on diagnostic pitfalls. Acta Cytol 1995;39:905–8.
46. Mulvany NJ, Khan A, Ostor A. Arias-Stella reaction associated with cervical pregnancy: report of a case with a cytologic presentation. 43. Shrago SS. The Arias-Stella reaction: a case report of a cytologic presentation. Acta Cytol 1977;21:310–3.
44. Albukerk JN, Gnecco CA. Atypical cytology in tubal pregnancy. J
Reprod Med 1977;19:273–6.
45. Pisharodi LR, Jovanoska S. Spectrum of cytologic changes in pregnancy: a review of 100 abnormal cervicovaginal smears, with emphasis on diagnostic pitfalls. Acta Cytol 1995;39:905–8.
46. Mulvany NJ, Khan A, Ostor A. Arias-Stella reaction associated with cervical pregnancy: report of a case with a cytologic presentation. 44. Albukerk JN, Gnecco CA. Atypical cytology in tubal pregnancy. J
Reprod Med 1977;19:273–6.
45. Pisharodi LR, Jovanoska S. Spectrum of cytologic changes in pregnancy: a review of 100 abnormal cervicovaginal smears, with emphasis on diagnostic pitfalls. Acta Cytol 1995;39:905–8.
46. Mulvany NJ, Khan A, Ostor A. Arias-Stella reaction associated with cervical pregnancy: report of a case with a cytologic presentation. Reprod Med 1977;19:273–6.
45. Pisharodi LR, Jovanoska S. Spectrum of cytologic changes in pregnancy: a review of 100 abnormal cervicovaginal smears, with emphasis on diagnostic pitfalls. Acta Cytol 1995;39:905–8.
46. Mulvany NJ, Khan A, Ostor A. Arias-Stella reaction associated with cervical pregnancy: report of a case with a cytologic presentation. 45. Pisharodi LR, Jovanoska S. Spectrum of cytologic changes in pregnancy: a review of 100 abnormal cervicovaginal smears, with emphasis on diagnostic pitfalls. Acta Cytol 1995;39:905–8.
46. Mulvany NJ, Khan A, Ostor A. Arias-Stella reaction associated with cervical pregnancy: report of a case with a cytologic presentation. 46. Mulvany NJ, Khan A, Ostor A. Arias-Stella reaction associated with cervical pregnancy: report of a case with a cytologic presentation. Acta Cytol 1994;38:218–22.
47. Yates WA, Persad RV, Stanbridge CM. The Arias-Stella reaction in the cervix: a case report with cervical cytology. Cytopathology 47. Yates WA, Persad RV, Stanbridge CM. The Arias-Stella reaction in the cervix: a case report with cervical cytology. Cytopathology 1997;8:40–4. 48. Michael CW Esfahani FM, Pregnancy-related changes: a retrospective review of 278 cervical smears. Diagn Cytopathol 1997;
17:99–107. 49. Benoit JL, Kini SR. “Arias-Stella reaction”-like changes in endocervical glandular epithelium in cervical smears during pregnancy and postpartum states- a potential diagnostic pitfall. Diagn
Cytopathol 1966;14:349–55.
50. Chiara F. Le cellule poliploide nellendometrio umano. Ann Obstet
Gynecol 1960;82:1131–36.
51. Wagner D, Richart RM. Polyploidy in the human endometrium with the Arias-Stella reaction. Arch Pathol 1968;85:475–80.
52. Arias Stella J. Características, significación y patogenia de las alteraciones atípicas endometriales asociadas a la presencia de tejido coriónico. Anales de la Facultad de Medicina de la Universidad
Nac. Mayor de San Marcos de Lima 1960;42:523–46.
53. Silverberg SG. Arias Stella phenomenon in spontaneous and therapeutic abortion. Am J Obstet Gynecol 1982;112:777–80.
54. Velardo JT. Essentials of human reproduction. Oxford: Oxford University Press, 1958. 55. Schmidt-Matthiesen H. The normal endometrium. New York: Mc-
Graw-Hill,, 1963. 56. Arias-Stella J. Abnormal endometrial changes induced in the rat: the effects of chorionic hormone and estrogen. Arch Pathol 1955;
60:49–58. 57. Arias-Stella J. Endometrial changes in the rat: the effect of estrogen when administered after an interval following castration. Arch
Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413. 17:99–107. 49. Benoit JL, Kini SR. “Arias-Stella reaction”-like changes in endocervical glandular epithelium in cervical smears during pregnancy and postpartum states- a potential diagnostic pitfall. Diagn
Cytopathol 1966;14:349–55.
50. Chiara F. Le cellule poliploide nellendometrio umano. Ann Obstet
Gynecol 1960;82:1131–36.
51. Wagner D, Richart RM. Polyploidy in the human endometrium with the Arias-Stella reaction. Arch Pathol 1968;85:475–80.
52. Arias Stella J. Características, significación y patogenia de las alteraciones atípicas endometriales asociadas a la presencia de tejido coriónico. Anales de la Facultad de Medicina de la Universidad
Nac. Mayor de San Marcos de Lima 1960;42:523–46.
53. Silverberg SG. Arias Stella phenomenon in spontaneous and therapeutic abortion. Am J Obstet Gynecol 1982;112:777–80.
54. Velardo JT. Essentials of human reproduction. Oxford: Oxford University Press, 1958. 55. Schmidt-Matthiesen H. The normal endometrium. New York: Mc-
Graw-Hill,, 1963. 56. Arias-Stella J. Abnormal endometrial changes induced in the rat: the effects of chorionic hormone and estrogen. Arch Pathol 1955;
60:49–58. 57. Arias-Stella J. Endometrial changes in the rat: the effect of estrogen when administered after an interval following castration. Arch
Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413. Cytopathol 1966;14:349–55.
50. Chiara F. Le cellule poliploide nellendometrio umano. Ann Obstet
Gynecol 1960;82:1131–36.
51. Wagner D, Richart RM. Polyploidy in the human endometrium with the Arias-Stella reaction. Arch Pathol 1968;85:475–80.
52. Arias Stella J. Características, significación y patogenia de las alteraciones atípicas endometriales asociadas a la presencia de tejido coriónico. Anales de la Facultad de Medicina de la Universidad
Nac. Mayor de San Marcos de Lima 1960;42:523–46.
53. Silverberg SG. Arias Stella phenomenon in spontaneous and therapeutic abortion. Am J Obstet Gynecol 1982;112:777–80.
54. Velardo JT. Essentials of human reproduction. Oxford: Oxford University Press, 1958. 55. Schmidt-Matthiesen H. The normal endometrium. New York: Mc-
Graw-Hill,, 1963. 56. Arias-Stella J. Abnormal endometrial changes induced in the rat: the effects of chorionic hormone and estrogen. Arch Pathol 1955;
60:49–58. 57. Arias-Stella J. Endometrial changes in the rat: the effect of estrogen when administered after an interval following castration. Arch
Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413. 50. Chiara F. Le cellule poliploide nellendometrio umano. Ann Obstet
Gynecol 1960;82:1131–36.
51. Wagner D, Richart RM. Polyploidy in the human endometrium with the Arias-Stella reaction. Arch Pathol 1968;85:475–80.
52. Arias Stella J. Características, significación y patogenia de las alteraciones atípicas endometriales asociadas a la presencia de tejido coriónico. Anales de la Facultad de Medicina de la Universidad
Nac. Mayor de San Marcos de Lima 1960;42:523–46.
53. Silverberg SG. Arias Stella phenomenon in spontaneous and therapeutic abortion. Am J Obstet Gynecol 1982;112:777–80.
54. Velardo JT. Essentials of human reproduction. Oxford: Oxford University Press, 1958. 55. Schmidt-Matthiesen H. The normal endometrium. New York: Mc-
Graw-Hill,, 1963. 56. Arias-Stella J. Abnormal endometrial changes induced in the rat: the effects of chorionic hormone and estrogen. Arch Pathol 1955;
60:49–58. 57. Arias-Stella J. Endometrial changes in the rat: the effect of estrogen when administered after an interval following castration. Arch
Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413. Gynecol 1960;82:1131–36.
51. Wagner D, Richart RM. Polyploidy in the human endometrium with the Arias-Stella reaction. Arch Pathol 1968;85:475–80.
52. Arias Stella J. Características, significación y patogenia de las alteraciones atípicas endometriales asociadas a la presencia de tejido coriónico. Anales de la Facultad de Medicina de la Universidad
Nac. Mayor de San Marcos de Lima 1960;42:523–46.
53. Silverberg SG. Arias Stella phenomenon in spontaneous and therapeutic abortion. Am J Obstet Gynecol 1982;112:777–80.
54. Velardo JT. Essentials of human reproduction. Oxford: Oxford University Press, 1958. 55. Schmidt-Matthiesen H. The normal endometrium. New York: Mc-
Graw-Hill,, 1963. 56. Arias-Stella J. Abnormal endometrial changes induced in the rat: the effects of chorionic hormone and estrogen. Arch Pathol 1955;
60:49–58. 57. Arias-Stella J. Endometrial changes in the rat: the effect of estrogen when administered after an interval following castration. Arch
Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413. 51. Wagner D, Richart RM. Polyploidy in the human endometrium with the Arias-Stella reaction. Arch Pathol 1968;85:475–80.
52. Arias Stella J. Características, significación y patogenia de las alteraciones atípicas endometriales asociadas a la presencia de tejido coriónico. Anales de la Facultad de Medicina de la Universidad
Nac. Mayor de San Marcos de Lima 1960;42:523–46.
53. Silverberg SG. Arias Stella phenomenon in spontaneous and therapeutic abortion. Am J Obstet Gynecol 1982;112:777–80.
54. Velardo JT. Essentials of human reproduction. Oxford: Oxford University Press, 1958. 55. Schmidt-Matthiesen H. The normal endometrium. New York: Mc-
Graw-Hill,, 1963. 56. Arias-Stella J. Abnormal endometrial changes induced in the rat: the effects of chorionic hormone and estrogen. Arch Pathol 1955;
60:49–58. 57. Arias-Stella J. Endometrial changes in the rat: the effect of estrogen when administered after an interval following castration. Arch
Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413. 52. Arias Stella J. Características, significación y patogenia de las alteraciones atípicas endometriales asociadas a la presencia de tejido coriónico. Anales de la Facultad de Medicina de la Universidad
Nac. Mayor de San Marcos de Lima 1960;42:523–46.
53. Silverberg SG. Arias Stella phenomenon in spontaneous and therapeutic abortion. Am J Obstet Gynecol 1982;112:777–80.
54. Velardo JT. Essentials of human reproduction. Oxford: Oxford University Press, 1958. 55. Schmidt-Matthiesen H. The normal endometrium. New York: Mc-
Graw-Hill,, 1963. 56. Arias-Stella J. Abnormal endometrial changes induced in the rat: the effects of chorionic hormone and estrogen. Arch Pathol 1955;
60:49–58. 57. Arias-Stella J. Endometrial changes in the rat: the effect of estrogen when administered after an interval following castration. Arch
Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413. Nac. Mayor de San Marcos de Lima 1960;42:523–46.
53. Silverberg SG. Arias Stella phenomenon in spontaneous and therapeutic abortion. Am J Obstet Gynecol 1982;112:777–80.
54. Velardo JT. Essentials of human reproduction. Oxford: Oxford University Press, 1958. 55. Schmidt-Matthiesen H. The normal endometrium. New York: Mc-
Graw-Hill,, 1963. 56. Arias-Stella J. Abnormal endometrial changes induced in the rat: the effects of chorionic hormone and estrogen. Arch Pathol 1955;
60:49–58. 57. Arias-Stella J. Endometrial changes in the rat: the effect of estrogen when administered after an interval following castration. Arch
Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413. 53. Silverberg SG. Arias Stella phenomenon in spontaneous and therapeutic abortion. Am J Obstet Gynecol 1982;112:777–80.
54. Velardo JT. Essentials of human reproduction. Oxford: Oxford University Press, 1958. 55. Schmidt-Matthiesen H. The normal endometrium. New York: Mc-
Graw-Hill,, 1963. 56. Arias-Stella J. Abnormal endometrial changes induced in the rat: the effects of chorionic hormone and estrogen. Arch Pathol 1955;
60:49–58. 57. Arias-Stella J. Endometrial changes in the rat: the effect of estrogen when administered after an interval following castration. Arch
Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413. 54. Velardo JT. Essentials of human reproduction. Oxford: Oxford University Press, 1958. 55. Schmidt-Matthiesen H. The normal endometrium. New York: Mc-
Graw-Hill,, 1963. 56. Arias-Stella J. Abnormal endometrial changes induced in the rat: the effects of chorionic hormone and estrogen. Arch Pathol 1955;
60:49–58. 57. Arias-Stella J. Endometrial changes in the rat: the effect of estrogen when administered after an interval following castration. Arch
Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413. Graw-Hill,, 1963. 56. Arias-Stella J. Abnormal endometrial changes induced in the rat: the effects of chorionic hormone and estrogen. Arch Pathol 1955;
60:49–58. 57. Arias-Stella J. Endometrial changes in the rat: the effect of estrogen when administered after an interval following castration. Arch
Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413. 60:49–58. 57. Arias-Stella J. Endometrial changes in the rat: the effect of estrogen when administered after an interval following castration. Arch
Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413. Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413. 58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413. 59. Dockerty MB, Smith RA, Symmonds RE. Pseudomalignant endometrial changes induced by administration of new synthetic progestins. Proc Mayo Clin 1959;34:321–8.
60. Azzopardi JG, Zayid JG. Synthetic progestogen oestrogen therapy and uterine changes. J Clin Pathol 1967;20:731–7.
61. Huettner PC, Gersell DJ. Arias Stella reaction in nonpregnant women: a clinicopathologic study of nine cases. Int J Gynecol
Pathol 1994;13:241–7.
62. Good RG, Moyer DL. Estrogen-progesterone relationships in the development of secretory endometrium. Fertil Steril 1968;19:
37–49. 63. Hamilton TH, Teng CS, Means AR. Early estrogen action, nuclear synthesis and accumulation of protein correlated with enhancement of two DNA dependent RNA polymerase activities. Proc
Natl Acad Sci U S A 1968;59:1265–72.
64. Nordgvist S. The synthesis of DNA and RNA in normal human endometrium in short-term. incubation in vitro and its response to oestradiol and progesterone. J Endocrinol 1970;48:17–28.
65. O’Malley BW. Studies on the molecular mechanisms of steroid hormone action. The Harvey lecture. New York: Academic Press,
1978:53–90. 66. Allred DC, Harvey JM, Berardo M, et al. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod
Pathol 1998;11:155–68.
67. Doss BJ, Logani S, Jacques SM, et al The Arias Stella reaction and its variants: histopathologic and immunohistochemical features. 60. Azzopardi JG, Zayid JG. Synthetic progestogen oestrogen therapy and uterine changes. J Clin Pathol 1967;20:731–7.
61. Huettner PC, Gersell DJ. Arias Stella reaction in nonpregnant women: a clinicopathologic study of nine cases. Int J Gynecol
Pathol 1994;13:241–7.
62. Good RG, Moyer DL. Estrogen-progesterone relationships in the development of secretory endometrium. Fertil Steril 1968;19:
37–49. 63. Hamilton TH, Teng CS, Means AR. Early estrogen action, nuclear synthesis and accumulation of protein correlated with enhancement of two DNA dependent RNA polymerase activities. Proc
Natl Acad Sci U S A 1968;59:1265–72.
64. Nordgvist S. The synthesis of DNA and RNA in normal human endometrium in short-term. incubation in vitro and its response to oestradiol and progesterone. J Endocrinol 1970;48:17–28.
65. O’Malley BW. Studies on the molecular mechanisms of steroid hormone action. The Harvey lecture. New York: Academic Press,
1978:53–90. 66. Allred DC, Harvey JM, Berardo M, et al. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod
Pathol 1998;11:155–68.
67. Doss BJ, Logani S, Jacques SM, et al The Arias Stella reaction and its variants: histopathologic and immunohistochemical features. 61. Huettner PC, Gersell DJ. Arias Stella reaction in nonpregnant women: a clinicopathologic study of nine cases. Int J Gynecol
Pathol 1994;13:241–7.
62. Good RG, Moyer DL. Estrogen-progesterone relationships in the development of secretory endometrium. Fertil Steril 1968;19:
37–49. 63. Hamilton TH, Teng CS, Means AR. Early estrogen action, nuclear synthesis and accumulation of protein correlated with enhancement of two DNA dependent RNA polymerase activities. Proc
Natl Acad Sci U S A 1968;59:1265–72.
64. Nordgvist S. The synthesis of DNA and RNA in normal human endometrium in short-term. incubation in vitro and its response to oestradiol and progesterone. J Endocrinol 1970;48:17–28.
65. O’Malley BW. Studies on the molecular mechanisms of steroid hormone action. The Harvey lecture. New York: Academic Press,
1978:53–90. 66. Allred DC, Harvey JM, Berardo M, et al. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod
Pathol 1998;11:155–68.
67. Doss BJ, Logani S, Jacques SM, et al The Arias Stella reaction and its variants: histopathologic and immunohistochemical features. Pathol 1994;13:241–7.
62. Good RG, Moyer DL. Estrogen-progesterone relationships in the development of secretory endometrium. Fertil Steril 1968;19:
37–49. 63. Hamilton TH, Teng CS, Means AR. Early estrogen action, nuclear synthesis and accumulation of protein correlated with enhancement of two DNA dependent RNA polymerase activities. Proc
Natl Acad Sci U S A 1968;59:1265–72.
64. Nordgvist S. The synthesis of DNA and RNA in normal human endometrium in short-term. incubation in vitro and its response to oestradiol and progesterone. J Endocrinol 1970;48:17–28.
65. O’Malley BW. Studies on the molecular mechanisms of steroid hormone action. The Harvey lecture. New York: Academic Press,
1978:53–90. 66. Allred DC, Harvey JM, Berardo M, et al. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod
Pathol 1998;11:155–68.
67. Doss BJ, Logani S, Jacques SM, et al The Arias Stella reaction and its variants: histopathologic and immunohistochemical features. 62. Good RG, Moyer DL. Estrogen-progesterone relationships in the development of secretory endometrium. Fertil Steril 1968;19:
37–49. 63. Hamilton TH, Teng CS, Means AR. Early estrogen action, nuclear synthesis and accumulation of protein correlated with enhancement of two DNA dependent RNA polymerase activities. Proc
Natl Acad Sci U S A 1968;59:1265–72.
64. Nordgvist S. The synthesis of DNA and RNA in normal human endometrium in short-term. incubation in vitro and its response to oestradiol and progesterone. J Endocrinol 1970;48:17–28.
65. O’Malley BW. Studies on the molecular mechanisms of steroid hormone action. The Harvey lecture. New York: Academic Press,
1978:53–90. 66. Allred DC, Harvey JM, Berardo M, et al. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod
Pathol 1998;11:155–68.
67. Doss BJ, Logani S, Jacques SM, et al The Arias Stella reaction and its variants: histopathologic and immunohistochemical features. 37–49. 63. Hamilton TH, Teng CS, Means AR. Early estrogen action, nuclear synthesis and accumulation of protein correlated with enhancement of two DNA dependent RNA polymerase activities. Proc
Natl Acad Sci U S A 1968;59:1265–72.
64. Nordgvist S. The synthesis of DNA and RNA in normal human endometrium in short-term. incubation in vitro and its response to oestradiol and progesterone. J Endocrinol 1970;48:17–28.
65. O’Malley BW. Studies on the molecular mechanisms of steroid hormone action. The Harvey lecture. New York: Academic Press,
1978:53–90. 66. Allred DC, Harvey JM, Berardo M, et al. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod
Pathol 1998;11:155–68.
67. Doss BJ, Logani S, Jacques SM, et al The Arias Stella reaction and its variants: histopathologic and immunohistochemical features. Natl Acad Sci U S A 1968;59:1265–72.
64. Nordgvist S. The synthesis of DNA and RNA in normal human endometrium in short-term. incubation in vitro and its response to oestradiol and progesterone. J Endocrinol 1970;48:17–28.
65. O’Malley BW. Studies on the molecular mechanisms of steroid hormone action. The Harvey lecture. New York: Academic Press,
1978:53–90. 66. Allred DC, Harvey JM, Berardo M, et al. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod
Pathol 1998;11:155–68.
67. Doss BJ, Logani S, Jacques SM, et al The Arias Stella reaction and its variants: histopathologic and immunohistochemical features. 64. Nordgvist S. The synthesis of DNA and RNA in normal human endometrium in short-term. incubation in vitro and its response to oestradiol and progesterone. J Endocrinol 1970;48:17–28.
65. O’Malley BW. Studies on the molecular mechanisms of steroid hormone action. The Harvey lecture. New York: Academic Press,
1978:53–90. 66. Allred DC, Harvey JM, Berardo M, et al. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod
Pathol 1998;11:155–68.
67. Doss BJ, Logani S, Jacques SM, et al The Arias Stella reaction and its variants: histopathologic and immunohistochemical features. 65. O’Malley BW. Studies on the molecular mechanisms of steroid hormone action. The Harvey lecture. New York: Academic Press,
1978:53–90. 66. Allred DC, Harvey JM, Berardo M, et al. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod
Pathol 1998;11:155–68.
67. Doss BJ, Logani S, Jacques SM, et al The Arias Stella reaction and its variants: histopathologic and immunohistochemical features. 1978:53–90. 66. Allred DC, Harvey JM, Berardo M, et al. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod
Pathol 1998;11:155–68.
67. Doss BJ, Logani S, Jacques SM, et al The Arias Stella reaction and its variants: histopathologic and immunohistochemical features. Pathol 1998;11:155–68.
67. Doss BJ, Logani S, Jacques SM, et al The Arias Stella reaction and its variants: histopathologic and immunohistochemical features. 67. Doss BJ, Logani S, Jacques SM, et al The Arias Stella reaction and its variants: histopathologic and immunohistochemical features. Mod Pathol 1998;11:102a.
68. Revelli A, Massobrlo M, Tesarik J. Nongenomic actions of steroid hormones in reproductive tissues. Endocr Rev 1998;19: 3–17.
69. Márquez-Monter H, Estávez R, Cervantes M. Plausible explicación del fenómeno de Arias-Stella con base en el conocimiento del ciclo celular. Patología 1996;34:307–10.
70. Sambasiva Rao M, Reddy JK. Cell and tissue adaptations to injury. In: Sirica AE, ed. Cellular and molecular pathogenesis. Philadelphia:
Lippincott-Raven, 1996. 71. Peters H, Frank IM. The cytologic interpretation of the prostatic smear. Surg Gynecol Obstet 1952;94:69–76.
72. Arias-Stella J, Takano-Morón J. Atypical epithelial changes in the seminal vesicals. AMA. Arch Pathol 1958;66:761–6.
73. Kuo T, Gómez LG. Monstrous epithelial cells in human epididymis and seminal vesicles: a pseudomalignant change. Am J Surg
Pathol 1981;5:483–90.
74. Shah VI, Ro JY, Amin MB, et al. Histologic variations in the epididymis: findings in 167 orchiectomy specimens. Am J Surg
Pathol 1998;22:990–6.
75. Matos PS, Bisi M, Medeiros-Neto G. Dyshormonagenetic goiter: a morphologic and immunohistochemical study. Endocr Pathol 68. Revelli A, Massobrlo M, Tesarik J. Nongenomic actions of steroid hormones in reproductive tissues. Endocr Rev 1998;19: 3–17.
69. Márquez-Monter H, Estávez R, Cervantes M. Plausible explicación del fenómeno de Arias-Stella con base en el conocimiento del ciclo celular. Patología 1996;34:307–10.
70. Sambasiva Rao M, Reddy JK. Cell and tissue adaptations to injury. In: Sirica AE, ed. Cellular and molecular pathogenesis. Philadelphia:
Lippincott-Raven, 1996. 71. Peters H, Frank IM. The cytologic interpretation of the prostatic smear. Surg Gynecol Obstet 1952;94:69–76.
72. Arias-Stella J, Takano-Morón J. Atypical epithelial changes in the seminal vesicals. AMA. Arch Pathol 1958;66:761–6.
73. Kuo T, Gómez LG. Monstrous epithelial cells in human epididymis and seminal vesicles: a pseudomalignant change. Am J Surg
Pathol 1981;5:483–90.
74. Shah VI, Ro JY, Amin MB, et al. Histologic variations in the epididymis: findings in 167 orchiectomy specimens. Am J Surg
Pathol 1998;22:990–6.
75. Matos PS, Bisi M, Medeiros-Neto G. Dyshormonagenetic goiter: a morphologic and immunohistochemical study. Endocr Pathol 69. Márquez-Monter H, Estávez R, Cervantes M. Plausible explicación del fenómeno de Arias-Stella con base en el conocimiento del ciclo celular. Patología 1996;34:307–10.
70. Sambasiva Rao M, Reddy JK. Cell and tissue adaptations to injury. In: Sirica AE, ed. Cellular and molecular pathogenesis. Philadelphia:
Lippincott-Raven, 1996. 71. Peters H, Frank IM. The cytologic interpretation of the prostatic smear. Surg Gynecol Obstet 1952;94:69–76.
72. Arias-Stella J, Takano-Morón J. Atypical epithelial changes in the seminal vesicals. AMA. Arch Pathol 1958;66:761–6.
73. Kuo T, Gómez LG. Monstrous epithelial cells in human epididymis and seminal vesicles: a pseudomalignant change. Am J Surg
Pathol 1981;5:483–90.
74. Shah VI, Ro JY, Amin MB, et al. Histologic variations in the epididymis: findings in 167 orchiectomy specimens. Am J Surg
Pathol 1998;22:990–6.
75. Matos PS, Bisi M, Medeiros-Neto G. Dyshormonagenetic goiter: a morphologic and immunohistochemical study. Endocr Pathol 70. Sambasiva Rao M, Reddy JK. Cell and tissue adaptations to injury. In: Sirica AE, ed. Cellular and molecular pathogenesis. Philadelphia:
Lippincott-Raven, 1996. 71. Peters H, Frank IM. The cytologic interpretation of the prostatic smear. Surg Gynecol Obstet 1952;94:69–76.
72. Arias-Stella J, Takano-Morón J. Atypical epithelial changes in the seminal vesicals. AMA. Arch Pathol 1958;66:761–6.
73. Kuo T, Gómez LG. Monstrous epithelial cells in human epididymis and seminal vesicles: a pseudomalignant change. Am J Surg
Pathol 1981;5:483–90.
74. Shah VI, Ro JY, Amin MB, et al. Histologic variations in the epididymis: findings in 167 orchiectomy specimens. Am J Surg
Pathol 1998;22:990–6.
75. Matos PS, Bisi M, Medeiros-Neto G. Dyshormonagenetic goiter: a morphologic and immunohistochemical study. Endocr Pathol Lippincott-Raven, 1996. 71. Peters H, Frank IM. The cytologic interpretation of the prostatic smear. Surg Gynecol Obstet 1952;94:69–76.
72. Arias-Stella J, Takano-Morón J. Atypical epithelial changes in the seminal vesicals. AMA. Arch Pathol 1958;66:761–6.
73. Kuo T, Gómez LG. Monstrous epithelial cells in human epididymis and seminal vesicles: a pseudomalignant change. Am J Surg
Pathol 1981;5:483–90.
74. Shah VI, Ro JY, Amin MB, et al. Histologic variations in the epididymis: findings in 167 orchiectomy specimens. Am J Surg
Pathol 1998;22:990–6.
75. Matos PS, Bisi M, Medeiros-Neto G. Dyshormonagenetic goiter: a morphologic and immunohistochemical study. Endocr Pathol 72. Arias-Stella J, Takano-Morón J. Atypical epithelial changes in the seminal vesicals. AMA. Arch Pathol 1958;66:761–6.
73. Kuo T, Gómez LG. Monstrous epithelial cells in human epididymis and seminal vesicles: a pseudomalignant change. Am J Surg
Pathol 1981;5:483–90.
74. Shah VI, Ro JY, Amin MB, et al. Histologic variations in the epididymis: findings in 167 orchiectomy specimens. Am J Surg
Pathol 1998;22:990–6.
75. Matos PS, Bisi M, Medeiros-Neto G. Dyshormonagenetic goiter: a morphologic and immunohistochemical study. Endocr Pathol 73. Kuo T, Gómez LG. Monstrous epithelial cells in human epididymis and seminal vesicles: a pseudomalignant change. Am J Surg
Pathol 1981;5:483–90.
74. Shah VI, Ro JY, Amin MB, et al. Histologic variations in the epididymis: findings in 167 orchiectomy specimens. Am J Surg
Pathol 1998;22:990–6.
75. Matos PS, Bisi M, Medeiros-Neto G. Dyshormonagenetic goiter: a morphologic and immunohistochemical study. Endocr Pathol Pathol 1981;5:483–90.
74. Shah VI, Ro JY, Amin MB, et al. Histologic variations in the epididymis: findings in 167 orchiectomy specimens. Am J Surg
Pathol 1998;22:990–6.
75. Matos PS, Bisi M, Medeiros-Neto G. Dyshormonagenetic goiter: a morphologic and immunohistochemical study. Endocr Pathol 74. Shah VI, Ro JY, Amin MB, et al. Histologic variations in the epididymis: findings in 167 orchiectomy specimens. Am J Surg
Pathol 1998;22:990–6.
75. Matos PS, Bisi M, Medeiros-Neto G. Dyshormonagenetic goiter: a morphologic and immunohistochemical study. Endocr Pathol Pathol 1998;22:990–6.
75. Matos PS, Bisi M, Medeiros-Neto G. Dyshormonagenetic goiter: a morphologic and immunohistochemical study. Endocr Pathol 75. Matos PS, Bisi M, Medeiros-Neto G. Dyshormonagenetic goiter: a morphologic and immunohistochemical study. Endocr Pathol 1994;5:59–65.
monograph N-14. Baltimore: Williams & Wilkins, 1973:185–212.
6. Dorland’s Illustrated Medical Dictionary. ed 9. Madrid: McGraw-
Hill–Interamericana de España, 1992.
7. Lloyd HED, Feinberg R. The Arias Stella reaction: a nonspecific
involutional phenomenon in intra as well as extrauterine pregnancy.
Am J Clin Pathol 1965;43:428–32.
8. Hendrickson MR, Longacre TA, Kempson RL. The uterine corpus. In: Sternberg SS, ed Diagnostic surgical pathology. 3rd ed. Philadelphia:
Lippincott Williams & Wilkins, 1999. 9. Mazur MT, Hendrickson MR, Kempson RL. Optically clear nuclei: an alteration of endometrial epithelium in the presence of trophoblast. Am J Surg Pathol 1983;7:415–23.
10. Dardi LE, Ariano L, Ariano MC, et al. Arias-Stella reaction with prominent nuclear pseudo inclusions simulating herpetic endometritis.
8. Hendrickson MR, Longacre TA, Kempson RL. The uterine corpus.
In: Sternberg SS, ed Diagnostic surgical pathology. 3rd ed. Philadelphia:
Lippincott Williams & Wilkins, 1999. 9. Mazur MT, Hendrickson MR, Kempson RL. Optically clear nuclei: an alteration of endometrial epithelium in the presence of trophoblast. Am J Surg Pathol 1983;7:415–23.
10. Dardi LE, Ariano L, Ariano MC, et al. Arias-Stella reaction with prominent nuclear pseudo inclusions simulating herpetic endometritis.
Lippincott Williams & Wilkins, 1999.
9. Mazur MT, Hendrickson MR, Kempson RL. Optically clear nuclei:
an alteration of endometrial epithelium in the presence of
trophoblast. Am J Surg Pathol 1983;7:415–23.
10. Dardi LE, Ariano L, Ariano MC, et al. Arias-Stella reaction with prominent nuclear pseudo inclusions simulating herpetic endometritis.
10. Dardi LE, Ariano L, Ariano MC, et al. Arias-Stella reaction with
prominent nuclear pseudo inclusions simulating herpetic endometritis.
Diagn Gynecol Obstet 1982;4:127–32.
11. Opitz E. Das Erkennen abgelaufener früher Schwanqerschaet an ausgeschabten Schleimhautbrockeln. Ztschr Gerburtsh Gynak
11. Opitz E. Das Erkennen abgelaufener früher Schwanqerschaet an
ausgeschabten Schleimhautbrockeln. Ztschr Gerburtsh Gynak
Ztschr Gerburtsh Gynak1900;42:1–40, pl. 1–2.
12. Arias-Stella J. Atypical endometrial changes produced by chorionic
tissue. Hum Pathol 1972;3:450–3.
13. Arias-Stella J, Jr., Arias-Velasquez, A, Arias-Stella J. Normal and abnormal mitoses in the atypical endometrial change associated with chorionic tissue effect. Am J Surg Pathol 1994;18:694–701.
14. de Brux J, Ancla M. Arias-Stella endometrial atypias case study with the electron microscope. Am J Obstet Gynecol 1964;89:
661–9. 15. Thasher TV, Richart RM. Ultrastructure of the Arias-Stella reaction.
13. Arias-Stella J, Jr., Arias-Velasquez, A, Arias-Stella J. Normal and
abnormal mitoses in the atypical endometrial change associated
with chorionic tissue effect. Am J Surg Pathol 1994;18:694–701.
14. de Brux J, Ancla M. Arias-Stella endometrial atypias case study with the electron microscope. Am J Obstet Gynecol 1964;89:
661–9. 15. Thasher TV, Richart RM. Ultrastructure of the Arias-Stella reaction.
14. de Brux J, Ancla M. Arias-Stella endometrial atypias case study
with the electron microscope. Am J Obstet Gynecol 1964;89:
661–9. 15. Thasher TV, Richart RM. Ultrastructure of the Arias-Stella reaction.
661–9.
15. Thasher TV, Richart RM. Ultrastructure of the Arias-Stella reaction.
Am J Obstet Gynecol 1972;112:113–20.
16. Salazar H, Burgess F. Correlaciones histológico ultrastructurales en la reacción endometrial de Arias Stella. VIII Congreso Latinoamericano de Patología. Programa, resumen, p. 41. Maracaibo 5–10, Dic. 1971. 17. Arias-Stella J, Gutiérrez J. Frecuencia y significado de las atipias endometriales en el embarazo ectópico. Rev Lat Am Anat Patol
16. Salazar H, Burgess F. Correlaciones histológico ultrastructurales
en la reacción endometrial de Arias Stella. VIII Congreso Latinoamericano
de Patología. Programa, resumen, p. 41. Maracaibo 5–10,
Dic. 1971.
17. Arias-Stella J, Gutiérrez J. Frecuencia y significado de las atipias
endometriales en el embarazo ectópico. Rev Lat Am Anat Patol
Rev Lat Am Anat Patol1957;1:81–91.
18. Arias-Stella J. A topographic study of uterine epithelial atypia
associated with chorionic tissue: demonstration of alteration in the
endocervix. Cancer 1959;12:782–90.
19. Moller NE. The Arias Stella phenomenon in endometriosis. Acta
Obstet Gynecol Scand 1959;38:271–4.
20. Cariani DJ, Guderian A. Gestational atypia in endocervical polyps: the Arias-Stella reaction. Am J Obstet Gynecol 1966;95:589–90.
21. McCormick CJ, Mennai-Williams RA. Tripolar mitotic figures occurring in an Arias-Stella reaction within an endocervical polyp.
19. Moller NE. The Arias Stella phenomenon in endometriosis. Acta
Obstet Gynecol Scand 1959;38:271–4.
20. Cariani DJ, Guderian A. Gestational atypia in endocervical polyps: the Arias-Stella reaction. Am J Obstet Gynecol 1966;95:589–90.
21. McCormick CJ, Mennai-Williams RA. Tripolar mitotic figures occurring in an Arias-Stella reaction within an endocervical polyp.
Obstet Gynecol Scand 1959;38:271–4.
20. Cariani DJ, Guderian A. Gestational atypia in endocervical polyps: the Arias-Stella reaction. Am J Obstet Gynecol 1966;95:589–90.
21. McCormick CJ, Mennai-Williams RA. Tripolar mitotic figures occurring in an Arias-Stella reaction within an endocervical polyp.
20. Cariani DJ, Guderian A. Gestational atypia in endocervical polyps:
the Arias-Stella reaction. Am J Obstet Gynecol 1966;95:589–90.
21. McCormick CJ, Mennai-Williams RA. Tripolar mitotic figures occurring in an Arias-Stella reaction within an endocervical polyp.
21. McCormick CJ, Mennai-Williams RA. Tripolar mitotic figures occurring
in an Arias-Stella reaction within an endocervical polyp.
Histopathology 1995;26:575–6.
22. Richmond H. Vaginal clear cell adenocarcinoma and adenosis in monozygotic twins [abstract] J Clin Pathol 1979;32 :416.
23. Jones WMD, Woodruff MD, Erlandson MD. Lewis JR. Desrelated clear adenocarcinoma of the vagina in pregnancy. Obstet
Gynecol 1981;57:765.
24. Blaustein A, Kantius M, Kaganowicz A, et al. Inclusions in ovaries of females aged day 1–30 years. Int J Gynecol Pathol 1982;1:
145–53. 25. Giltman LI. Modified Arias Stella reaction in paratubal epithelium.
22. Richmond H. Vaginal clear cell adenocarcinoma and adenosis in
monozygotic twins [abstract] J Clin Pathol 1979;32 :416.
23. Jones WMD, Woodruff MD, Erlandson MD. Lewis JR. Desrelated clear adenocarcinoma of the vagina in pregnancy. Obstet
Gynecol 1981;57:765.
24. Blaustein A, Kantius M, Kaganowicz A, et al. Inclusions in ovaries of females aged day 1–30 years. Int J Gynecol Pathol 1982;1:
145–53. 25. Giltman LI. Modified Arias Stella reaction in paratubal epithelium.
23. Jones WMD, Woodruff MD, Erlandson MD. Lewis JR. Desrelated
clear adenocarcinoma of the vagina in pregnancy. Obstet
Gynecol 1981;57:765.
24. Blaustein A, Kantius M, Kaganowicz A, et al. Inclusions in ovaries of females aged day 1–30 years. Int J Gynecol Pathol 1982;1:
145–53. 25. Giltman LI. Modified Arias Stella reaction in paratubal epithelium.
Gynecol 1981;57:765.
24. Blaustein A, Kantius M, Kaganowicz A, et al. Inclusions in ovaries of females aged day 1–30 years. Int J Gynecol Pathol 1982;1:
145–53. 25. Giltman LI. Modified Arias Stella reaction in paratubal epithelium.
24. Blaustein A, Kantius M, Kaganowicz A, et al. Inclusions in ovaries
of females aged day 1–30 years. Int J Gynecol Pathol 1982;1:
145–53. 25. Giltman LI. Modified Arias Stella reaction in paratubal epithelium.
145–53.
25. Giltman LI. Modified Arias Stella reaction in paratubal epithelium.
Arch Gynecol 1986;237:243–5.
26. Spaun E, Toft B. Epithelial atypia in ovarian mucinous cystadenoma during the puerperium. Acta Obstet Gynecol Scand 1986;65:
505–6. 27. Albukerk JN, Berlin M. Unilateral lutein cyst in pregnancy. N Y
State J Med 1976;76:259–61.
28. Clement PB, Scully RE. Large solitary luteinized follicle cyst of pregnancy and puerperium. Am J Surg Pathol 1980;4:431–8.
29. Holmes DJ, Lyle WH. How early in pregnancy does the Arias- Stella reaction occur. Arch Pathol 1973;95:302–3.
30. Dahlerup A, Jorgensen VJ. The Arias-Stella phenomenon postpartum. In: Ohlsson H. Proceedings of the Tenth Scandinavian Congress
of Obstetrics and Gynecology. Lun, Sweden, 1958:76–84.
31. Oertel Y. The Arias-Stella reaction revisited. Arch Pathol Lab Med
26. Spaun E, Toft B. Epithelial atypia in ovarian mucinous cystadenoma
during the puerperium. Acta Obstet Gynecol Scand 1986;65:
505–6. 27. Albukerk JN, Berlin M. Unilateral lutein cyst in pregnancy. N Y
State J Med 1976;76:259–61.
28. Clement PB, Scully RE. Large solitary luteinized follicle cyst of pregnancy and puerperium. Am J Surg Pathol 1980;4:431–8.
29. Holmes DJ, Lyle WH. How early in pregnancy does the Arias- Stella reaction occur. Arch Pathol 1973;95:302–3.
30. Dahlerup A, Jorgensen VJ. The Arias-Stella phenomenon postpartum. In: Ohlsson H. Proceedings of the Tenth Scandinavian Congress
of Obstetrics and Gynecology. Lun, Sweden, 1958:76–84.
31. Oertel Y. The Arias-Stella reaction revisited. Arch Pathol Lab Med
505–6.
27. Albukerk JN, Berlin M. Unilateral lutein cyst in pregnancy. N Y
State J Med 1976;76:259–61.
28. Clement PB, Scully RE. Large solitary luteinized follicle cyst of pregnancy and puerperium. Am J Surg Pathol 1980;4:431–8.
29. Holmes DJ, Lyle WH. How early in pregnancy does the Arias- Stella reaction occur. Arch Pathol 1973;95:302–3.
30. Dahlerup A, Jorgensen VJ. The Arias-Stella phenomenon postpartum. In: Ohlsson H. Proceedings of the Tenth Scandinavian Congress
of Obstetrics and Gynecology. Lun, Sweden, 1958:76–84.
31. Oertel Y. The Arias-Stella reaction revisited. Arch Pathol Lab Med
State J Med 1976;76:259–61.
28. Clement PB, Scully RE. Large solitary luteinized follicle cyst of pregnancy and puerperium. Am J Surg Pathol 1980;4:431–8.
29. Holmes DJ, Lyle WH. How early in pregnancy does the Arias- Stella reaction occur. Arch Pathol 1973;95:302–3.
30. Dahlerup A, Jorgensen VJ. The Arias-Stella phenomenon postpartum. In: Ohlsson H. Proceedings of the Tenth Scandinavian Congress
of Obstetrics and Gynecology. Lun, Sweden, 1958:76–84.
31. Oertel Y. The Arias-Stella reaction revisited. Arch Pathol Lab Med
28. Clement PB, Scully RE. Large solitary luteinized follicle cyst of
pregnancy and puerperium. Am J Surg Pathol 1980;4:431–8.
29. Holmes DJ, Lyle WH. How early in pregnancy does the Arias- Stella reaction occur. Arch Pathol 1973;95:302–3.
30. Dahlerup A, Jorgensen VJ. The Arias-Stella phenomenon postpartum. In: Ohlsson H. Proceedings of the Tenth Scandinavian Congress
of Obstetrics and Gynecology. Lun, Sweden, 1958:76–84.
31. Oertel Y. The Arias-Stella reaction revisited. Arch Pathol Lab Med
29. Holmes DJ, Lyle WH. How early in pregnancy does the Arias-
Stella reaction occur. Arch Pathol 1973;95:302–3.
30. Dahlerup A, Jorgensen VJ. The Arias-Stella phenomenon postpartum. In: Ohlsson H. Proceedings of the Tenth Scandinavian Congress
of Obstetrics and Gynecology. Lun, Sweden, 1958:76–84.
31. Oertel Y. The Arias-Stella reaction revisited. Arch Pathol Lab Med
30. Dahlerup A, Jorgensen VJ. The Arias-Stella phenomenon postpartum.
In: Ohlsson H. Proceedings of the Tenth Scandinavian Congress
of Obstetrics and Gynecology. Lun, Sweden, 1958:76–84.
31. Oertel Y. The Arias-Stella reaction revisited. Arch Pathol Lab Med
of Obstetrics and Gynecology. Lun, Sweden, 1958:76–84.
31. Oertel Y. The Arias-Stella reaction revisited. Arch Pathol Lab Med
31. Oertel Y. The Arias-Stella reaction revisited. Arch Pathol Lab Med
Arch Pathol Lab Med1978;102:651–4.
32. Saavedra JA, Garcia-Miranda JL, Galera H, et al. The Arias Stella
phenomenon and its diagnostic value in ectopic pregnancy: studies
of 86 cases with review of literature [in German]. Zentralbl Gynakol
Zentralbl Gynakol1975;97:1166–75.
33. Szadujkis-Lincel H. Arias-Stella reaction and its value in the diagnosis
of ectopic pregnancy [in Polish]. Ginekol Pol 1970;41:
903–6. 34. Kurman R.J. Blaustein’s pathology of the female genital tract. 4th
edn. New York: Springer-Verlag, 1994. 35. Milchgrub SMD, Sandstad JMD. Arias Stella reaction in fallopian tube epithelium: a light and electron microscopic study with a review of the literature. Am J Clin Pathol 1991;95:892–5.
36. Schneider V. Arias-Stella reaction of the endocervix: frequency and location. Acta Cytol 1981;25:224–8.
37. Cove H. The Arias-Stella reaction occurring in the endocervix in pregnancy: recognition and comparison with adenocarcinoma of the endocervix. Am J Surg Pathol 1979;3:567–8.
38. Rhatigan RM. Endocervical gland atypia secondary to Arias-Stella change. Arch Pathol Lab Med 1992;116:943–6.
39. Cariani DJ, Guderian A. Gestational atypia in endocervical polyps: the Arias-Stella reaction. Am J Obstet Gynecol 1996;95:589–90.
40. McCormick CJ, Menai-Williams RA. Tripolar mitotic figures occurring in an Arias-Stella reaction within an endocervical polyp.
903–6.
34. Kurman R.J. Blaustein’s pathology of the female genital tract. 4th
edn. New York: Springer-Verlag, 1994. 35. Milchgrub SMD, Sandstad JMD. Arias Stella reaction in fallopian tube epithelium: a light and electron microscopic study with a review of the literature. Am J Clin Pathol 1991;95:892–5.
36. Schneider V. Arias-Stella reaction of the endocervix: frequency and location. Acta Cytol 1981;25:224–8.
37. Cove H. The Arias-Stella reaction occurring in the endocervix in pregnancy: recognition and comparison with adenocarcinoma of the endocervix. Am J Surg Pathol 1979;3:567–8.
38. Rhatigan RM. Endocervical gland atypia secondary to Arias-Stella change. Arch Pathol Lab Med 1992;116:943–6.
39. Cariani DJ, Guderian A. Gestational atypia in endocervical polyps: the Arias-Stella reaction. Am J Obstet Gynecol 1996;95:589–90.
40. McCormick CJ, Menai-Williams RA. Tripolar mitotic figures occurring in an Arias-Stella reaction within an endocervical polyp.
edn. New York: Springer-Verlag, 1994.
35. Milchgrub SMD, Sandstad JMD. Arias Stella reaction in fallopian
tube epithelium: a light and electron microscopic study with a
review of the literature. Am J Clin Pathol 1991;95:892–5.
36. Schneider V. Arias-Stella reaction of the endocervix: frequency and location. Acta Cytol 1981;25:224–8.
37. Cove H. The Arias-Stella reaction occurring in the endocervix in pregnancy: recognition and comparison with adenocarcinoma of the endocervix. Am J Surg Pathol 1979;3:567–8.
38. Rhatigan RM. Endocervical gland atypia secondary to Arias-Stella change. Arch Pathol Lab Med 1992;116:943–6.
39. Cariani DJ, Guderian A. Gestational atypia in endocervical polyps: the Arias-Stella reaction. Am J Obstet Gynecol 1996;95:589–90.
40. McCormick CJ, Menai-Williams RA. Tripolar mitotic figures occurring in an Arias-Stella reaction within an endocervical polyp.
36. Schneider V. Arias-Stella reaction of the endocervix: frequency
and location. Acta Cytol 1981;25:224–8.
37. Cove H. The Arias-Stella reaction occurring in the endocervix in pregnancy: recognition and comparison with adenocarcinoma of the endocervix. Am J Surg Pathol 1979;3:567–8.
38. Rhatigan RM. Endocervical gland atypia secondary to Arias-Stella change. Arch Pathol Lab Med 1992;116:943–6.
39. Cariani DJ, Guderian A. Gestational atypia in endocervical polyps: the Arias-Stella reaction. Am J Obstet Gynecol 1996;95:589–90.
40. McCormick CJ, Menai-Williams RA. Tripolar mitotic figures occurring in an Arias-Stella reaction within an endocervical polyp.
37. Cove H. The Arias-Stella reaction occurring in the endocervix in
pregnancy: recognition and comparison with adenocarcinoma of
the endocervix. Am J Surg Pathol 1979;3:567–8.
38. Rhatigan RM. Endocervical gland atypia secondary to Arias-Stella change. Arch Pathol Lab Med 1992;116:943–6.
39. Cariani DJ, Guderian A. Gestational atypia in endocervical polyps: the Arias-Stella reaction. Am J Obstet Gynecol 1996;95:589–90.
40. McCormick CJ, Menai-Williams RA. Tripolar mitotic figures occurring in an Arias-Stella reaction within an endocervical polyp.
38. Rhatigan RM. Endocervical gland atypia secondary to Arias-Stella
change. Arch Pathol Lab Med 1992;116:943–6.
39. Cariani DJ, Guderian A. Gestational atypia in endocervical polyps: the Arias-Stella reaction. Am J Obstet Gynecol 1996;95:589–90.
40. McCormick CJ, Menai-Williams RA. Tripolar mitotic figures occurring in an Arias-Stella reaction within an endocervical polyp.
39. Cariani DJ, Guderian A. Gestational atypia in endocervical polyps:
the Arias-Stella reaction. Am J Obstet Gynecol 1996;95:589–90.
40. McCormick CJ, Menai-Williams RA. Tripolar mitotic figures occurring in an Arias-Stella reaction within an endocervical polyp.
40. McCormick CJ, Menai-Williams RA. Tripolar mitotic figures occurring
in an Arias-Stella reaction within an endocervical polyp.
Histopathology 1995;26:575–6.
41. Hilrich NM, Hipke MM. Endometrial and cytologic atypism in the postabortal state. Obstet Gynecol 1955;6:452–4.
42. Albukerk JN. False-positive cytology in ectopic pregnancy N Engl
J Med 1974;291:1142.
43. Shrago SS. The Arias-Stella reaction: a case report of a cytologic presentation. Acta Cytol 1977;21:310–3.
44. Albukerk JN, Gnecco CA. Atypical cytology in tubal pregnancy. J
Reprod Med 1977;19:273–6.
45. Pisharodi LR, Jovanoska S. Spectrum of cytologic changes in pregnancy: a review of 100 abnormal cervicovaginal smears, with emphasis on diagnostic pitfalls. Acta Cytol 1995;39:905–8.
46. Mulvany NJ, Khan A, Ostor A. Arias-Stella reaction associated with cervical pregnancy: report of a case with a cytologic presentation.
41. Hilrich NM, Hipke MM. Endometrial and cytologic atypism in the
postabortal state. Obstet Gynecol 1955;6:452–4.
42. Albukerk JN. False-positive cytology in ectopic pregnancy N Engl
J Med 1974;291:1142.
43. Shrago SS. The Arias-Stella reaction: a case report of a cytologic presentation. Acta Cytol 1977;21:310–3.
44. Albukerk JN, Gnecco CA. Atypical cytology in tubal pregnancy. J
Reprod Med 1977;19:273–6.
45. Pisharodi LR, Jovanoska S. Spectrum of cytologic changes in pregnancy: a review of 100 abnormal cervicovaginal smears, with emphasis on diagnostic pitfalls. Acta Cytol 1995;39:905–8.
46. Mulvany NJ, Khan A, Ostor A. Arias-Stella reaction associated with cervical pregnancy: report of a case with a cytologic presentation.
42. Albukerk JN. False-positive cytology in ectopic pregnancy N Engl
J Med 1974;291:1142.
43. Shrago SS. The Arias-Stella reaction: a case report of a cytologic presentation. Acta Cytol 1977;21:310–3.
44. Albukerk JN, Gnecco CA. Atypical cytology in tubal pregnancy. J
Reprod Med 1977;19:273–6.
45. Pisharodi LR, Jovanoska S. Spectrum of cytologic changes in pregnancy: a review of 100 abnormal cervicovaginal smears, with emphasis on diagnostic pitfalls. Acta Cytol 1995;39:905–8.
46. Mulvany NJ, Khan A, Ostor A. Arias-Stella reaction associated with cervical pregnancy: report of a case with a cytologic presentation.
J Med 1974;291:1142.
43. Shrago SS. The Arias-Stella reaction: a case report of a cytologic presentation. Acta Cytol 1977;21:310–3.
44. Albukerk JN, Gnecco CA. Atypical cytology in tubal pregnancy. J
Reprod Med 1977;19:273–6.
45. Pisharodi LR, Jovanoska S. Spectrum of cytologic changes in pregnancy: a review of 100 abnormal cervicovaginal smears, with emphasis on diagnostic pitfalls. Acta Cytol 1995;39:905–8.
46. Mulvany NJ, Khan A, Ostor A. Arias-Stella reaction associated with cervical pregnancy: report of a case with a cytologic presentation.
43. Shrago SS. The Arias-Stella reaction: a case report of a cytologic
presentation. Acta Cytol 1977;21:310–3.
44. Albukerk JN, Gnecco CA. Atypical cytology in tubal pregnancy. J
Reprod Med 1977;19:273–6.
45. Pisharodi LR, Jovanoska S. Spectrum of cytologic changes in pregnancy: a review of 100 abnormal cervicovaginal smears, with emphasis on diagnostic pitfalls. Acta Cytol 1995;39:905–8.
46. Mulvany NJ, Khan A, Ostor A. Arias-Stella reaction associated with cervical pregnancy: report of a case with a cytologic presentation.
44. Albukerk JN, Gnecco CA. Atypical cytology in tubal pregnancy. J
Reprod Med 1977;19:273–6.
45. Pisharodi LR, Jovanoska S. Spectrum of cytologic changes in pregnancy: a review of 100 abnormal cervicovaginal smears, with emphasis on diagnostic pitfalls. Acta Cytol 1995;39:905–8.
46. Mulvany NJ, Khan A, Ostor A. Arias-Stella reaction associated with cervical pregnancy: report of a case with a cytologic presentation.
Reprod Med 1977;19:273–6.
45. Pisharodi LR, Jovanoska S. Spectrum of cytologic changes in pregnancy: a review of 100 abnormal cervicovaginal smears, with emphasis on diagnostic pitfalls. Acta Cytol 1995;39:905–8.
46. Mulvany NJ, Khan A, Ostor A. Arias-Stella reaction associated with cervical pregnancy: report of a case with a cytologic presentation.
45. Pisharodi LR, Jovanoska S. Spectrum of cytologic changes in pregnancy:
a review of 100 abnormal cervicovaginal smears, with emphasis
on diagnostic pitfalls. Acta Cytol 1995;39:905–8.
46. Mulvany NJ, Khan A, Ostor A. Arias-Stella reaction associated with cervical pregnancy: report of a case with a cytologic presentation.
46. Mulvany NJ, Khan A, Ostor A. Arias-Stella reaction associated
with cervical pregnancy: report of a case with a cytologic presentation.
Acta Cytol 1994;38:218–22.
47. Yates WA, Persad RV, Stanbridge CM. The Arias-Stella reaction in the cervix: a case report with cervical cytology. Cytopathology
47. Yates WA, Persad RV, Stanbridge CM. The Arias-Stella reaction
in the cervix: a case report with cervical cytology. Cytopathology
Cytopathology1997;8:40–4.
48. Michael CW Esfahani FM, Pregnancy-related changes: a retrospective
review of 278 cervical smears. Diagn Cytopathol 1997;
17:99–107. 49. Benoit JL, Kini SR. “Arias-Stella reaction”-like changes in endocervical glandular epithelium in cervical smears during pregnancy and postpartum states- a potential diagnostic pitfall. Diagn
Cytopathol 1966;14:349–55.
50. Chiara F. Le cellule poliploide nellendometrio umano. Ann Obstet
Gynecol 1960;82:1131–36.
51. Wagner D, Richart RM. Polyploidy in the human endometrium with the Arias-Stella reaction. Arch Pathol 1968;85:475–80.
52. Arias Stella J. Características, significación y patogenia de las alteraciones atípicas endometriales asociadas a la presencia de tejido coriónico. Anales de la Facultad de Medicina de la Universidad
Nac. Mayor de San Marcos de Lima 1960;42:523–46.
53. Silverberg SG. Arias Stella phenomenon in spontaneous and therapeutic abortion. Am J Obstet Gynecol 1982;112:777–80.
54. Velardo JT. Essentials of human reproduction. Oxford: Oxford University Press, 1958. 55. Schmidt-Matthiesen H. The normal endometrium. New York: Mc-
Graw-Hill,, 1963. 56. Arias-Stella J. Abnormal endometrial changes induced in the rat: the effects of chorionic hormone and estrogen. Arch Pathol 1955;
60:49–58. 57. Arias-Stella J. Endometrial changes in the rat: the effect of estrogen when administered after an interval following castration. Arch
Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413.
17:99–107.
49. Benoit JL, Kini SR. “Arias-Stella reaction”-like changes in endocervical
glandular epithelium in cervical smears during pregnancy
and postpartum states- a potential diagnostic pitfall. Diagn
Cytopathol 1966;14:349–55.
50. Chiara F. Le cellule poliploide nellendometrio umano. Ann Obstet
Gynecol 1960;82:1131–36.
51. Wagner D, Richart RM. Polyploidy in the human endometrium with the Arias-Stella reaction. Arch Pathol 1968;85:475–80.
52. Arias Stella J. Características, significación y patogenia de las alteraciones atípicas endometriales asociadas a la presencia de tejido coriónico. Anales de la Facultad de Medicina de la Universidad
Nac. Mayor de San Marcos de Lima 1960;42:523–46.
53. Silverberg SG. Arias Stella phenomenon in spontaneous and therapeutic abortion. Am J Obstet Gynecol 1982;112:777–80.
54. Velardo JT. Essentials of human reproduction. Oxford: Oxford University Press, 1958. 55. Schmidt-Matthiesen H. The normal endometrium. New York: Mc-
Graw-Hill,, 1963. 56. Arias-Stella J. Abnormal endometrial changes induced in the rat: the effects of chorionic hormone and estrogen. Arch Pathol 1955;
60:49–58. 57. Arias-Stella J. Endometrial changes in the rat: the effect of estrogen when administered after an interval following castration. Arch
Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413.
Cytopathol 1966;14:349–55.
50. Chiara F. Le cellule poliploide nellendometrio umano. Ann Obstet
Gynecol 1960;82:1131–36.
51. Wagner D, Richart RM. Polyploidy in the human endometrium with the Arias-Stella reaction. Arch Pathol 1968;85:475–80.
52. Arias Stella J. Características, significación y patogenia de las alteraciones atípicas endometriales asociadas a la presencia de tejido coriónico. Anales de la Facultad de Medicina de la Universidad
Nac. Mayor de San Marcos de Lima 1960;42:523–46.
53. Silverberg SG. Arias Stella phenomenon in spontaneous and therapeutic abortion. Am J Obstet Gynecol 1982;112:777–80.
54. Velardo JT. Essentials of human reproduction. Oxford: Oxford University Press, 1958. 55. Schmidt-Matthiesen H. The normal endometrium. New York: Mc-
Graw-Hill,, 1963. 56. Arias-Stella J. Abnormal endometrial changes induced in the rat: the effects of chorionic hormone and estrogen. Arch Pathol 1955;
60:49–58. 57. Arias-Stella J. Endometrial changes in the rat: the effect of estrogen when administered after an interval following castration. Arch
Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413.
50. Chiara F. Le cellule poliploide nellendometrio umano. Ann Obstet
Gynecol 1960;82:1131–36.
51. Wagner D, Richart RM. Polyploidy in the human endometrium with the Arias-Stella reaction. Arch Pathol 1968;85:475–80.
52. Arias Stella J. Características, significación y patogenia de las alteraciones atípicas endometriales asociadas a la presencia de tejido coriónico. Anales de la Facultad de Medicina de la Universidad
Nac. Mayor de San Marcos de Lima 1960;42:523–46.
53. Silverberg SG. Arias Stella phenomenon in spontaneous and therapeutic abortion. Am J Obstet Gynecol 1982;112:777–80.
54. Velardo JT. Essentials of human reproduction. Oxford: Oxford University Press, 1958. 55. Schmidt-Matthiesen H. The normal endometrium. New York: Mc-
Graw-Hill,, 1963. 56. Arias-Stella J. Abnormal endometrial changes induced in the rat: the effects of chorionic hormone and estrogen. Arch Pathol 1955;
60:49–58. 57. Arias-Stella J. Endometrial changes in the rat: the effect of estrogen when administered after an interval following castration. Arch
Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413.
Gynecol 1960;82:1131–36.
51. Wagner D, Richart RM. Polyploidy in the human endometrium with the Arias-Stella reaction. Arch Pathol 1968;85:475–80.
52. Arias Stella J. Características, significación y patogenia de las alteraciones atípicas endometriales asociadas a la presencia de tejido coriónico. Anales de la Facultad de Medicina de la Universidad
Nac. Mayor de San Marcos de Lima 1960;42:523–46.
53. Silverberg SG. Arias Stella phenomenon in spontaneous and therapeutic abortion. Am J Obstet Gynecol 1982;112:777–80.
54. Velardo JT. Essentials of human reproduction. Oxford: Oxford University Press, 1958. 55. Schmidt-Matthiesen H. The normal endometrium. New York: Mc-
Graw-Hill,, 1963. 56. Arias-Stella J. Abnormal endometrial changes induced in the rat: the effects of chorionic hormone and estrogen. Arch Pathol 1955;
60:49–58. 57. Arias-Stella J. Endometrial changes in the rat: the effect of estrogen when administered after an interval following castration. Arch
Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413.
51. Wagner D, Richart RM. Polyploidy in the human endometrium
with the Arias-Stella reaction. Arch Pathol 1968;85:475–80.
52. Arias Stella J. Características, significación y patogenia de las alteraciones atípicas endometriales asociadas a la presencia de tejido coriónico. Anales de la Facultad de Medicina de la Universidad
Nac. Mayor de San Marcos de Lima 1960;42:523–46.
53. Silverberg SG. Arias Stella phenomenon in spontaneous and therapeutic abortion. Am J Obstet Gynecol 1982;112:777–80.
54. Velardo JT. Essentials of human reproduction. Oxford: Oxford University Press, 1958. 55. Schmidt-Matthiesen H. The normal endometrium. New York: Mc-
Graw-Hill,, 1963. 56. Arias-Stella J. Abnormal endometrial changes induced in the rat: the effects of chorionic hormone and estrogen. Arch Pathol 1955;
60:49–58. 57. Arias-Stella J. Endometrial changes in the rat: the effect of estrogen when administered after an interval following castration. Arch
Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413.
52. Arias Stella J. Características, significación y patogenia de las
alteraciones atípicas endometriales asociadas a la presencia de
tejido coriónico. Anales de la Facultad de Medicina de la Universidad
Nac. Mayor de San Marcos de Lima 1960;42:523–46.
53. Silverberg SG. Arias Stella phenomenon in spontaneous and therapeutic abortion. Am J Obstet Gynecol 1982;112:777–80.
54. Velardo JT. Essentials of human reproduction. Oxford: Oxford University Press, 1958. 55. Schmidt-Matthiesen H. The normal endometrium. New York: Mc-
Graw-Hill,, 1963. 56. Arias-Stella J. Abnormal endometrial changes induced in the rat: the effects of chorionic hormone and estrogen. Arch Pathol 1955;
60:49–58. 57. Arias-Stella J. Endometrial changes in the rat: the effect of estrogen when administered after an interval following castration. Arch
Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413.
Nac. Mayor de San Marcos de Lima 1960;42:523–46.
53. Silverberg SG. Arias Stella phenomenon in spontaneous and therapeutic abortion. Am J Obstet Gynecol 1982;112:777–80.
54. Velardo JT. Essentials of human reproduction. Oxford: Oxford University Press, 1958. 55. Schmidt-Matthiesen H. The normal endometrium. New York: Mc-
Graw-Hill,, 1963. 56. Arias-Stella J. Abnormal endometrial changes induced in the rat: the effects of chorionic hormone and estrogen. Arch Pathol 1955;
60:49–58. 57. Arias-Stella J. Endometrial changes in the rat: the effect of estrogen when administered after an interval following castration. Arch
Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413.
53. Silverberg SG. Arias Stella phenomenon in spontaneous and therapeutic
abortion. Am J Obstet Gynecol 1982;112:777–80.
54. Velardo JT. Essentials of human reproduction. Oxford: Oxford University Press, 1958. 55. Schmidt-Matthiesen H. The normal endometrium. New York: Mc-
Graw-Hill,, 1963. 56. Arias-Stella J. Abnormal endometrial changes induced in the rat: the effects of chorionic hormone and estrogen. Arch Pathol 1955;
60:49–58. 57. Arias-Stella J. Endometrial changes in the rat: the effect of estrogen when administered after an interval following castration. Arch
Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413.
54. Velardo JT. Essentials of human reproduction. Oxford: Oxford
University Press, 1958.
55. Schmidt-Matthiesen H. The normal endometrium. New York: Mc-
Graw-Hill,, 1963. 56. Arias-Stella J. Abnormal endometrial changes induced in the rat: the effects of chorionic hormone and estrogen. Arch Pathol 1955;
60:49–58. 57. Arias-Stella J. Endometrial changes in the rat: the effect of estrogen when administered after an interval following castration. Arch
Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413.
Graw-Hill,, 1963.
56. Arias-Stella J. Abnormal endometrial changes induced in the rat:
the effects of chorionic hormone and estrogen. Arch Pathol 1955;
60:49–58. 57. Arias-Stella J. Endometrial changes in the rat: the effect of estrogen when administered after an interval following castration. Arch
Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413.
60:49–58.
57. Arias-Stella J. Endometrial changes in the rat: the effect of estrogen
when administered after an interval following castration. Arch
Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413.
Pathol 1955;60:59–62.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413.
58. Dallenbach FD. Experimentelle Untersuchngen zur Genese des
Arias-Stella-Phanomens. Vrh Dtsch Ges Pathol 1966;50:413.
Vrh Dtsch Ges Pathol 1966;50:413.59. Dockerty MB, Smith RA, Symmonds RE. Pseudomalignant endometrial
changes induced by administration of new synthetic progestins.
Proc Mayo Clin 1959;34:321–8.
60. Azzopardi JG, Zayid JG. Synthetic progestogen oestrogen therapy and uterine changes. J Clin Pathol 1967;20:731–7.
61. Huettner PC, Gersell DJ. Arias Stella reaction in nonpregnant women: a clinicopathologic study of nine cases. Int J Gynecol
Pathol 1994;13:241–7.
62. Good RG, Moyer DL. Estrogen-progesterone relationships in the development of secretory endometrium. Fertil Steril 1968;19:
37–49. 63. Hamilton TH, Teng CS, Means AR. Early estrogen action, nuclear synthesis and accumulation of protein correlated with enhancement of two DNA dependent RNA polymerase activities. Proc
Natl Acad Sci U S A 1968;59:1265–72.
64. Nordgvist S. The synthesis of DNA and RNA in normal human endometrium in short-term. incubation in vitro and its response to oestradiol and progesterone. J Endocrinol 1970;48:17–28.
65. O’Malley BW. Studies on the molecular mechanisms of steroid hormone action. The Harvey lecture. New York: Academic Press,
1978:53–90. 66. Allred DC, Harvey JM, Berardo M, et al. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod
Pathol 1998;11:155–68.
67. Doss BJ, Logani S, Jacques SM, et al The Arias Stella reaction and its variants: histopathologic and immunohistochemical features.
60. Azzopardi JG, Zayid JG. Synthetic progestogen oestrogen therapy
and uterine changes. J Clin Pathol 1967;20:731–7.
61. Huettner PC, Gersell DJ. Arias Stella reaction in nonpregnant women: a clinicopathologic study of nine cases. Int J Gynecol
Pathol 1994;13:241–7.
62. Good RG, Moyer DL. Estrogen-progesterone relationships in the development of secretory endometrium. Fertil Steril 1968;19:
37–49. 63. Hamilton TH, Teng CS, Means AR. Early estrogen action, nuclear synthesis and accumulation of protein correlated with enhancement of two DNA dependent RNA polymerase activities. Proc
Natl Acad Sci U S A 1968;59:1265–72.
64. Nordgvist S. The synthesis of DNA and RNA in normal human endometrium in short-term. incubation in vitro and its response to oestradiol and progesterone. J Endocrinol 1970;48:17–28.
65. O’Malley BW. Studies on the molecular mechanisms of steroid hormone action. The Harvey lecture. New York: Academic Press,
1978:53–90. 66. Allred DC, Harvey JM, Berardo M, et al. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod
Pathol 1998;11:155–68.
67. Doss BJ, Logani S, Jacques SM, et al The Arias Stella reaction and its variants: histopathologic and immunohistochemical features.
61. Huettner PC, Gersell DJ. Arias Stella reaction in nonpregnant
women: a clinicopathologic study of nine cases. Int J Gynecol
Pathol 1994;13:241–7.
62. Good RG, Moyer DL. Estrogen-progesterone relationships in the development of secretory endometrium. Fertil Steril 1968;19:
37–49. 63. Hamilton TH, Teng CS, Means AR. Early estrogen action, nuclear synthesis and accumulation of protein correlated with enhancement of two DNA dependent RNA polymerase activities. Proc
Natl Acad Sci U S A 1968;59:1265–72.
64. Nordgvist S. The synthesis of DNA and RNA in normal human endometrium in short-term. incubation in vitro and its response to oestradiol and progesterone. J Endocrinol 1970;48:17–28.
65. O’Malley BW. Studies on the molecular mechanisms of steroid hormone action. The Harvey lecture. New York: Academic Press,
1978:53–90. 66. Allred DC, Harvey JM, Berardo M, et al. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod
Pathol 1998;11:155–68.
67. Doss BJ, Logani S, Jacques SM, et al The Arias Stella reaction and its variants: histopathologic and immunohistochemical features.
Pathol 1994;13:241–7.
62. Good RG, Moyer DL. Estrogen-progesterone relationships in the development of secretory endometrium. Fertil Steril 1968;19:
37–49. 63. Hamilton TH, Teng CS, Means AR. Early estrogen action, nuclear synthesis and accumulation of protein correlated with enhancement of two DNA dependent RNA polymerase activities. Proc
Natl Acad Sci U S A 1968;59:1265–72.
64. Nordgvist S. The synthesis of DNA and RNA in normal human endometrium in short-term. incubation in vitro and its response to oestradiol and progesterone. J Endocrinol 1970;48:17–28.
65. O’Malley BW. Studies on the molecular mechanisms of steroid hormone action. The Harvey lecture. New York: Academic Press,
1978:53–90. 66. Allred DC, Harvey JM, Berardo M, et al. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod
Pathol 1998;11:155–68.
67. Doss BJ, Logani S, Jacques SM, et al The Arias Stella reaction and its variants: histopathologic and immunohistochemical features.
62. Good RG, Moyer DL. Estrogen-progesterone relationships in the
development of secretory endometrium. Fertil Steril 1968;19:
37–49. 63. Hamilton TH, Teng CS, Means AR. Early estrogen action, nuclear synthesis and accumulation of protein correlated with enhancement of two DNA dependent RNA polymerase activities. Proc
Natl Acad Sci U S A 1968;59:1265–72.
64. Nordgvist S. The synthesis of DNA and RNA in normal human endometrium in short-term. incubation in vitro and its response to oestradiol and progesterone. J Endocrinol 1970;48:17–28.
65. O’Malley BW. Studies on the molecular mechanisms of steroid hormone action. The Harvey lecture. New York: Academic Press,
1978:53–90. 66. Allred DC, Harvey JM, Berardo M, et al. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod
Pathol 1998;11:155–68.
67. Doss BJ, Logani S, Jacques SM, et al The Arias Stella reaction and its variants: histopathologic and immunohistochemical features.
37–49.
63. Hamilton TH, Teng CS, Means AR. Early estrogen action, nuclear
synthesis and accumulation of protein correlated with enhancement
of two DNA dependent RNA polymerase activities. Proc
Natl Acad Sci U S A 1968;59:1265–72.
64. Nordgvist S. The synthesis of DNA and RNA in normal human endometrium in short-term. incubation in vitro and its response to oestradiol and progesterone. J Endocrinol 1970;48:17–28.
65. O’Malley BW. Studies on the molecular mechanisms of steroid hormone action. The Harvey lecture. New York: Academic Press,
1978:53–90. 66. Allred DC, Harvey JM, Berardo M, et al. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod
Pathol 1998;11:155–68.
67. Doss BJ, Logani S, Jacques SM, et al The Arias Stella reaction and its variants: histopathologic and immunohistochemical features.
Natl Acad Sci U S A 1968;59:1265–72.
64. Nordgvist S. The synthesis of DNA and RNA in normal human endometrium in short-term. incubation in vitro and its response to oestradiol and progesterone. J Endocrinol 1970;48:17–28.
65. O’Malley BW. Studies on the molecular mechanisms of steroid hormone action. The Harvey lecture. New York: Academic Press,
1978:53–90. 66. Allred DC, Harvey JM, Berardo M, et al. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod
Pathol 1998;11:155–68.
67. Doss BJ, Logani S, Jacques SM, et al The Arias Stella reaction and its variants: histopathologic and immunohistochemical features.
64. Nordgvist S. The synthesis of DNA and RNA in normal human
endometrium in short-term. incubation in vitro and its response to
oestradiol and progesterone. J Endocrinol 1970;48:17–28.
65. O’Malley BW. Studies on the molecular mechanisms of steroid hormone action. The Harvey lecture. New York: Academic Press,
1978:53–90. 66. Allred DC, Harvey JM, Berardo M, et al. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod
Pathol 1998;11:155–68.
67. Doss BJ, Logani S, Jacques SM, et al The Arias Stella reaction and its variants: histopathologic and immunohistochemical features.
65. O’Malley BW. Studies on the molecular mechanisms of steroid
hormone action. The Harvey lecture. New York: Academic Press,
1978:53–90. 66. Allred DC, Harvey JM, Berardo M, et al. Prognostic and predictive factors in breast cancer by immunohistochemical analysis. Mod
Pathol 1998;11:155–68.
67. Doss BJ, Logani S, Jacques SM, et al The Arias Stella reaction and its variants: histopathologic and immunohistochemical features.
1978:53–90.
66. Allred DC, Harvey JM, Berardo M, et al. Prognostic and predictive
factors in breast cancer by immunohistochemical analysis. Mod
Pathol 1998;11:155–68.
67. Doss BJ, Logani S, Jacques SM, et al The Arias Stella reaction and its variants: histopathologic and immunohistochemical features.
Pathol 1998;11:155–68.
67. Doss BJ, Logani S, Jacques SM, et al The Arias Stella reaction and its variants: histopathologic and immunohistochemical features.
67. Doss BJ, Logani S, Jacques SM, et al The Arias Stella reaction and
its variants: histopathologic and immunohistochemical features.
Mod Pathol 1998;11:102a.
68. Revelli A, Massobrlo M, Tesarik J. Nongenomic actions of steroid hormones in reproductive tissues. Endocr Rev 1998;19: 3–17.
69. Márquez-Monter H, Estávez R, Cervantes M. Plausible explicación del fenómeno de Arias-Stella con base en el conocimiento del ciclo celular. Patología 1996;34:307–10.
70. Sambasiva Rao M, Reddy JK. Cell and tissue adaptations to injury. In: Sirica AE, ed. Cellular and molecular pathogenesis. Philadelphia:
Lippincott-Raven, 1996. 71. Peters H, Frank IM. The cytologic interpretation of the prostatic smear. Surg Gynecol Obstet 1952;94:69–76.
72. Arias-Stella J, Takano-Morón J. Atypical epithelial changes in the seminal vesicals. AMA. Arch Pathol 1958;66:761–6.
73. Kuo T, Gómez LG. Monstrous epithelial cells in human epididymis and seminal vesicles: a pseudomalignant change. Am J Surg
Pathol 1981;5:483–90.
74. Shah VI, Ro JY, Amin MB, et al. Histologic variations in the epididymis: findings in 167 orchiectomy specimens. Am J Surg
Pathol 1998;22:990–6.
75. Matos PS, Bisi M, Medeiros-Neto G. Dyshormonagenetic goiter: a morphologic and immunohistochemical study. Endocr Pathol
68. Revelli A, Massobrlo M, Tesarik J. Nongenomic actions of steroid
hormones in reproductive tissues. Endocr Rev 1998;19: 3–17.
69. Márquez-Monter H, Estávez R, Cervantes M. Plausible explicación del fenómeno de Arias-Stella con base en el conocimiento del ciclo celular. Patología 1996;34:307–10.
70. Sambasiva Rao M, Reddy JK. Cell and tissue adaptations to injury. In: Sirica AE, ed. Cellular and molecular pathogenesis. Philadelphia:
Lippincott-Raven, 1996. 71. Peters H, Frank IM. The cytologic interpretation of the prostatic smear. Surg Gynecol Obstet 1952;94:69–76.
72. Arias-Stella J, Takano-Morón J. Atypical epithelial changes in the seminal vesicals. AMA. Arch Pathol 1958;66:761–6.
73. Kuo T, Gómez LG. Monstrous epithelial cells in human epididymis and seminal vesicles: a pseudomalignant change. Am J Surg
Pathol 1981;5:483–90.
74. Shah VI, Ro JY, Amin MB, et al. Histologic variations in the epididymis: findings in 167 orchiectomy specimens. Am J Surg
Pathol 1998;22:990–6.
75. Matos PS, Bisi M, Medeiros-Neto G. Dyshormonagenetic goiter: a morphologic and immunohistochemical study. Endocr Pathol
69. Márquez-Monter H, Estávez R, Cervantes M. Plausible explicación
del fenómeno de Arias-Stella con base en el conocimiento
del ciclo celular. Patología 1996;34:307–10.
70. Sambasiva Rao M, Reddy JK. Cell and tissue adaptations to injury. In: Sirica AE, ed. Cellular and molecular pathogenesis. Philadelphia:
Lippincott-Raven, 1996. 71. Peters H, Frank IM. The cytologic interpretation of the prostatic smear. Surg Gynecol Obstet 1952;94:69–76.
72. Arias-Stella J, Takano-Morón J. Atypical epithelial changes in the seminal vesicals. AMA. Arch Pathol 1958;66:761–6.
73. Kuo T, Gómez LG. Monstrous epithelial cells in human epididymis and seminal vesicles: a pseudomalignant change. Am J Surg
Pathol 1981;5:483–90.
74. Shah VI, Ro JY, Amin MB, et al. Histologic variations in the epididymis: findings in 167 orchiectomy specimens. Am J Surg
Pathol 1998;22:990–6.
75. Matos PS, Bisi M, Medeiros-Neto G. Dyshormonagenetic goiter: a morphologic and immunohistochemical study. Endocr Pathol
70. Sambasiva Rao M, Reddy JK. Cell and tissue adaptations to injury.
In: Sirica AE, ed. Cellular and molecular pathogenesis. Philadelphia:
Lippincott-Raven, 1996. 71. Peters H, Frank IM. The cytologic interpretation of the prostatic smear. Surg Gynecol Obstet 1952;94:69–76.
72. Arias-Stella J, Takano-Morón J. Atypical epithelial changes in the seminal vesicals. AMA. Arch Pathol 1958;66:761–6.
73. Kuo T, Gómez LG. Monstrous epithelial cells in human epididymis and seminal vesicles: a pseudomalignant change. Am J Surg
Pathol 1981;5:483–90.
74. Shah VI, Ro JY, Amin MB, et al. Histologic variations in the epididymis: findings in 167 orchiectomy specimens. Am J Surg
Pathol 1998;22:990–6.
75. Matos PS, Bisi M, Medeiros-Neto G. Dyshormonagenetic goiter: a morphologic and immunohistochemical study. Endocr Pathol
Lippincott-Raven, 1996.
71. Peters H, Frank IM. The cytologic interpretation of the prostatic
smear. Surg Gynecol Obstet 1952;94:69–76.
72. Arias-Stella J, Takano-Morón J. Atypical epithelial changes in the seminal vesicals. AMA. Arch Pathol 1958;66:761–6.
73. Kuo T, Gómez LG. Monstrous epithelial cells in human epididymis and seminal vesicles: a pseudomalignant change. Am J Surg
Pathol 1981;5:483–90.
74. Shah VI, Ro JY, Amin MB, et al. Histologic variations in the epididymis: findings in 167 orchiectomy specimens. Am J Surg
Pathol 1998;22:990–6.
75. Matos PS, Bisi M, Medeiros-Neto G. Dyshormonagenetic goiter: a morphologic and immunohistochemical study. Endocr Pathol
72. Arias-Stella J, Takano-Morón J. Atypical epithelial changes in the
seminal vesicals. AMA. Arch Pathol 1958;66:761–6.
73. Kuo T, Gómez LG. Monstrous epithelial cells in human epididymis and seminal vesicles: a pseudomalignant change. Am J Surg
Pathol 1981;5:483–90.
74. Shah VI, Ro JY, Amin MB, et al. Histologic variations in the epididymis: findings in 167 orchiectomy specimens. Am J Surg
Pathol 1998;22:990–6.
75. Matos PS, Bisi M, Medeiros-Neto G. Dyshormonagenetic goiter: a morphologic and immunohistochemical study. Endocr Pathol
73. Kuo T, Gómez LG. Monstrous epithelial cells in human epididymis
and seminal vesicles: a pseudomalignant change. Am J Surg
Pathol 1981;5:483–90.
74. Shah VI, Ro JY, Amin MB, et al. Histologic variations in the epididymis: findings in 167 orchiectomy specimens. Am J Surg
Pathol 1998;22:990–6.
75. Matos PS, Bisi M, Medeiros-Neto G. Dyshormonagenetic goiter: a morphologic and immunohistochemical study. Endocr Pathol
Pathol 1981;5:483–90.
74. Shah VI, Ro JY, Amin MB, et al. Histologic variations in the epididymis: findings in 167 orchiectomy specimens. Am J Surg
Pathol 1998;22:990–6.
75. Matos PS, Bisi M, Medeiros-Neto G. Dyshormonagenetic goiter: a morphologic and immunohistochemical study. Endocr Pathol
74. Shah VI, Ro JY, Amin MB, et al. Histologic variations in the
epididymis: findings in 167 orchiectomy specimens. Am J Surg
Pathol 1998;22:990–6.
75. Matos PS, Bisi M, Medeiros-Neto G. Dyshormonagenetic goiter: a morphologic and immunohistochemical study. Endocr Pathol
Pathol 1998;22:990–6.
75. Matos PS, Bisi M, Medeiros-Neto G. Dyshormonagenetic goiter: a morphologic and immunohistochemical study. Endocr Pathol
75. Matos PS, Bisi M, Medeiros-Neto G. Dyshormonagenetic goiter: a
morphologic and immunohistochemical study. Endocr Pathol
Endocr Pathol1994;5:59–65.
reaction in eight postmenopausal or perimenopausal
women who received treatment with progestational hormones.
Since the classic studies by Good and Moyer on the
Macaca mulatta, it has been shown that by adjusting the
doses of estrogens and progesterone, it is possible to obtain, experimentally, secretory or proliferative endometrial responses (62). All of the above supports, my proposition that the pathogenesis of the phenomenon depends on a balance of these two hormonal effects. How do we continue exploring along these lines of thought? Today, we know more about the hormonal mechanisms. In the case of female hormones, we know that there are cellular receptors, that estrogens stimulate the synthesis of DNA, RNA, and proteins, by a chain reaction mechanism, and that progesterone reduces the synthesis of DNA and RNA (63–65). We know the cell cycle and we can identify, in tissues, some of the factors of intermediation (Fig. 14). Therefore, there is room for further investigation. We have investigated, using immunohistochemical methods, the presence of estrogen and progesterone receptors and markers of cellular proliferation, Ki-67 and proliferating cell nuclear antigen (PCNA), in 20 cases of florid Arias-Stella reaction, compared with findings in the normal phases of the endometrium and in endometrial hyperplasia. In the absence of an accepted standardized method for evaluating immunohistochemical reactions, we have adopted the method recently proposed by Allred et al. (66) for scoring the immunostaining signal for estrogen receptors and progesterone receptors in breast cancer. In each case the best stained fields were chosen for the evaluation. In the Arias-Stella reaction we found that the estrogen receptors and the progesterone receptors (Table 5) had a total score less than in the normal functional phases and in hyperplasia. Scores for the cellular proliferation markers (Table 6) were also less than in the proliferative phase, but nevertheless, higher than those of the normal secretory phase. To summarize, the results of the immunohistochemical study show that: 1. Estrogen and progesterone receptors (Fig. 15) are present in the foci of the endometrial atypia. 2. The positive reaction for the proliferative factors, such as antigen Ki-67 and PCNA (Fig. 16), is also present in these foci. It should be stressed that estrogen receptors, progesterone receptors, Ki67, and PCNA have been found present in enlarged typical Arias-Stella reaction cells (Fig. 17). These results are, in essence, in agreement with the immunohistochemical study recently reported by Doss et al. (67). Steroid hormones can act by either of two ways: the nongenomic mechanism or the classic, or genomic, form (68). The nongenomic effects are fast—occurring in seconds or minutes—are highly specific, do not require nuclear receptors, and do not induce RNA or protein synthesis.
doses of estrogens and progesterone, it is possible to
obtain, experimentally, secretory or proliferative endometrial
responses (62).
All of the above supports, my proposition that the
pathogenesis of the phenomenon depends on a balance of
these two hormonal effects.
How do we continue exploring along these lines of
thought?
Today, we know more about the hormonal mechanisms.
In the case of female hormones, we know that
there are cellular receptors, that estrogens stimulate the
synthesis of DNA, RNA, and proteins, by a chain reaction
mechanism, and that progesterone reduces the synthesis
of DNA and RNA (63–65). We know the cell
cycle and we can identify, in tissues, some of the factors
of intermediation (Fig. 14). Therefore, there is room for
further investigation. We have investigated, using immunohistochemical
methods, the presence of estrogen and
progesterone receptors and markers of cellular proliferation,
Ki-67 and proliferating cell nuclear antigen
(PCNA), in 20 cases of florid Arias-Stella reaction, compared
with findings in the normal phases of the endometrium
and in endometrial hyperplasia.
In the absence of an accepted standardized method for
evaluating immunohistochemical reactions, we have
adopted the method recently proposed by Allred et al.
(66) for scoring the immunostaining signal for estrogen
receptors and progesterone receptors in breast cancer. In
each case the best stained fields were chosen for the
evaluation. In the Arias-Stella reaction we found that the
estrogen receptors and the progesterone receptors (Table
5) had a total score less than in the normal functional
phases and in hyperplasia.
Scores for the cellular proliferation markers (Table 6)
were also less than in the proliferative phase, but nevertheless,
higher than those of the normal secretory phase.
To summarize, the results of the immunohistochemical
study show that:
1. Estrogen and progesterone receptors (Fig. 15) are
present in the foci of the endometrial atypia.
2. The positive reaction for the proliferative factors,
such as antigen Ki-67 and PCNA (Fig. 16), is also
present in these foci. It should be stressed that estrogen
receptors, progesterone receptors, Ki67, and
PCNA have been found present in enlarged typical
Arias-Stella reaction cells (Fig. 17).
These results are, in essence, in agreement with the
immunohistochemical study recently reported by Doss et
al. (67).
Steroid hormones can act by either of two ways: the
nongenomic mechanism or the classic, or genomic, form
(68). The nongenomic effects are fast—occurring in seconds
or minutes—are highly specific, do not require
nuclear receptors, and do not induce RNA or protein
synthesis.
hormonal effects, today we have proved that when stimulation
is intense, the change can also occur in less sensitive
basal regions. From the beginning my colleagues
and I pointed out that not only the glandular but also the
covering epithelium could be affected and that the alteration
occurred in both the endocervix and the tubal epithelium
(17,18).
In recent years our observations and those of many
authors have demonstrated that under the stimulation of
chorionic tissue—gestational condition or trophoblastic
proliferation—the change can be observed in many territories
and lesions, including endometriosis (peritoneum,
subcutaneous, umbilical) (19); endocervical polyps
(20,21); vaginal adenosis (22,23); germinal inclusion
cysts (ovary) (24); para-ovarian and para-tubaric cysts
(25); and mucinous cystoadenoma 26).
It is interesting that Albukerk and Berlin (27) have
described nuclear changes that resemble the Arias-Stella
reaction in the luteal cyst of gestation and that Clement
and Scully (28) described similar atypias in luteinized
follicular cysts of gestation and puerperium.
CHRONOLOGY BETWEEN PRESENCE OF
CHORIONIC TISSUE AND
ARIAS-STELLA REACTION
Two questions that must be answered are: How early
in the gestation and how late after delivery does the
endometrial atypia occur? Fortunately, studies by
Holmes and Lyle (29) and Dahlerup and Jorgenson (30)
and the review by Oertel (31) of material that Hertig
examined to elucidate the early stages of human embryogenesis
have answered these questions.
PRACTICAL VALUE OF THE
ARIAS-STELLA REACTION
The accumulated information shows that in certain
clinical situations, finding the Arias-Stella reaction can
be especially significant, as an isolated histologic sign, or
as part of a group of changes, in making a diagnosis.
According to our experience and that of other investigators,
the change has been of histologic diagnostic significance
for recognizing early uterine pregnancy (12), ectopic
pregnancy (32,33), trophoblastic tumors (indirect
evidence), and postabortion or postpartum metropathies.
Histologic differential diagnosis can be problematic in
the following conditions: metastatic adenocarcinoma
versus foci of endometriosis in pregnancy (5); endometrial
adenocarcinoma versus florid Arias-Stella reaction
(8,34); adenocarcinoma versus Arias-Stella reaction in
fallopian tube (35); and atypical mucinous cystoadenomas,
germinal inclusion cysts, and paratubal cysts in
pregnancy and puerperium (26).
It is interesting to note that in recent years there has
been special emphasis in finding the change in the endocervix
and recognizing atypical cells in Papanicolaou
smears.
Schneider (36) has found the alteration in the endocervix
in 17 of 191 uteri, which were removed during
gestation, proving that the proximal segment of the cervical
canal was the most frequent location. Cove (37) and
Rhatigan (38) have described cases of endocervical
Arias-Stella reaction that caused confusion with premalignant
or malignant conditions. The same problem was
encountered by Cariani and Guderian (39) and McCormick
and Menaci-Williams (40) in endocervical polyps
with Arias-Stella reaction. McCormick and Menaci-
Williams reported the occurrence of tripolar mitoses,
confirming our finding of abnormal mitosis in the reaction.
In my experience the endocervical Arias-Stella reaction,
whether in normal mucosa or polyps, frequently
shows the monstrous cell pattern (Fig. 12) and gives rise
to the differential diagnosis with neoplastic processes.
The gestational state is often ignored and it is the debate
over the nature of the cervical lesion that reveals the
pregnancy condition.
Hilrich and Hipke (41) were the first to show that
atypical endometrial cells could appear in Papanicolaou
smears. Since then, many observers have verified the
same finding (42,43). Albukerk and Gnecco (44) pointed
out that the abnormal cells in the Papanicolaou smear
could be confused with neoplastic cytology and that they
are found more frequently in cases of ectopic pregnancy,
in which the lack of a uterine-placental barrier makes it
easier for desquamation and passage of the cells to the
vaginal fundus.
In recent years, Pisharodi and Jovanoska (45), Mulvany
et al. (46), Yates et al., (47), and Michael and
Esfahani (48), have reported observations showing that
the abnormal cytology due to Arias-Stella reaction, of the
endometrium or the endocervix, in pregnant women,
originates problems of cytologic interpretation. We have
verified this occurrence in and Figure 13 illustrates one
such case.
Recently, because of similar experiences, Benoit and
Kiny (49) recommended including Arias-Stella reaction
cells among the atypical glandular cells to be considered
in Papanicolaou smears from women in pregnancy or
puerperium.
PATHOGENESIS
An understanding of the mechanism of enlargement of
the nucleus and the unique histologic reaction is essential.
Three basic facts must first be mentioned:
1. Nuclear hypertrophy is due to an increase in the contents
of DNA. The finding of double Barr corpuscle
by Dahlerup and Jorgensen (30), the karyometric
studies of Chiara (50) and the Fulgen microspectrocytophotometric
determinations of Wagner and Richart
(51) early established that nuclei enlarge
because of polyploidism and that aneuploidism does
not exist.
2. The aspect of the histologic reaction is evidence of
occurrence of proliferative and secretory stimuli, acting
simultaneously.
3. The change can be present in normal physiologic conditions,
including term pregnancy (52), postpartum
(30), therapeutic abortion (51,53), and early normal
pregnancy (12).
The glandular changes in the endometrium are a consequence
of the action of estrogens and progesterone.
The former stimulate cellular proliferation and the latter
stimulate secretory activity (54,55).
With this background, since my first observations I
postulated that estrogen and progesterone are, in some
way, involved in the pathogenesis of the change. Early
on, using human chorionic hormones and estrogens, I
was able to obtain, experimentally, proliferative and secretory
activity simultaneously in normal rats, and, using
estrogens and progesterones in castrated rats to induce
the same changes. In these experiments I also observed
focal nuclear enlargement (56,57). In 1966, experimental
studies by Dr. Dallenbach (58) confirmed these findings.
Since then I have performed some experiments on
humans. Administering a combination of estrogens and
progesterone to postmenopausal women who were going
to have hysterectomies, I was able to induce, after 1
month of treatment in some of them, endometrial
changes that were focal and suggestive of the Arias-
Stella reaction (5).
In another experiment, due to the action of high doses
of estradiol and hydroxyprogesterone, I was able to produce
focal changes that were similar to the endometrial
atypia (5).
Conversely, since the observations of Dockerty et al.
(59) and Azzopardi and Zayid (60), it has been recognized
that therapy with synthetic progesterone-estrogen
can induce endometrial changes of the Arias-Stella reaction
type. Recently, Huettner and Gersell (61) have reported
the induction of what they consider Arias-Stella
located. The cells are frequently arranged in a palisading
fashion, with the nuclei at the same level. The affected
glands can show intraluminal papillary projections.
Since the original description, my colleagues and I
pointed out the occurrence of mitosis in the phenomenon
and, more recently, that they can be normal and abnormal
(Tables 2 and 3) (13). It is precisely in this model of
presentation that they are more frequent and abnormal
(Fig. 5). It is understandable why this histologic variant
is the one most likely to be confused with adenocarcinoma.
In my experience this model has been common in
cases of uterine abortion and ectopic pregnancy.
Secretory or Hypersecretory Pattern
Secretory or hypersecretory pattern is the classically
recognized form of reaction. The glandular cells display
intense and diffuse cytoplasmic vacuolization, which
predominates as a distinct morphologic feature. The enlarged
and hyperchromatic nuclei are usually pyknotic
(Fig. 6). Focally, one can distinguish cells that are less
vacuolated and show a dense cytoplasm (Fig. 7), which
is due to their different histochemical composition.
The comparative epithelial immunohistochemical profile
of the normal functional endometrium with the atypical
change has demonstrated that the epithelial membrane
antigen (EMA) and CK7 produce an intense and
homogenous reaction in both normal endometrium and
the Arias-Stella reaction (ASR) (Table 4). The vacuolization
that characterizes the hypersecretory pattern of
atypical change highlights the increased membranous localization
of staining with these markers, creating a
“chicken-wire” pattern (Fig. 8).
Ultrastructural studies done by de Brux (14), Thasher
and Richart (15), and Salazar and Burgess (16) have
shown few organelles and sparse particles that resemble
granules of ribonucleic acid in the clear cells, and a conspicuous
Golgi apparatus, vesicles of endoplasmic reticulum,
numerous mitochondrial crests, and Palade
grains in the dark cells. One detail that has been found
repeatedly is the presence of parallel rows of rough endoplasmic
reticulum (Fig. 9), which is a characteristic
described in various tumors of Mullerian origin. This
variant is found mainly in uterine abortions.
Regenerative, Proliferative, or Nonsecretory Pattern
In the regenerative, proliferative, or nonsecretory pattern
there is usually no evidence of secretory activity, or
it is minimal in the glandular cells. The enlarged nuclei
display a vesicular configuration or a granular chromatin
with a well-delineated nuclear membrane. The glands are
similar to those observed in the proliferative or regenerative
endometrium (Fig. 10). I have found this variant
in cases of hydatidiform mole, choriocarcinoma, ectopic
pregnancy, and uterine abortion.
Monstrous Cell Pattern
In rare cases, the monstrous cell pattern, which is usually
focal, affects the whole endometrium. The histologic
section is dominated by the presence of giant and bizarre
nuclei, which involve all the cells in the glands (Fig. 11).
The atypical nuclei show a dense, homogeneous chromatin
and, frequently, pseudoinclusions. This model of
atypia originates problems of histologic interpretation. In
our experience, my colleagues and I have found it in
0.5% of florid alterations.
LOCATION OF CHANGE
Even though the alteration was originally described in
the functional endometrium, which is more sensitive to
“Similar confessions could be made about other pathologic,
or for that matter, clinical entities, for which we
are all now on the alert.”
Dr. Novak was not a formal pathologist, as we understand
it today. He practiced clinical gynecology in Baltimore
and because he had helped Dr. Cullen, who had
organized the gynecologic pathology laboratory at Johns
Hopkins, he was now its director—a common situation
in the early years of surgical pathology. It is therefore not
surprising that pathologists of his time viewed him with
reservations and that his gynecology peers did not let
him admit patients to Johns Hopkins (4).
Looking back, his sincere, humble, and wise comment,
as well as the magnitude and quality of his contributions
to science, leave no doubt that he knew very
well the trade of pathology. He deserves the recognition
that is owed to him by our community of pathologists.
Since my first report, the original description has been
widely confirmed and mentioned in the literature (references
in [5]), although errors and inaccuracies occur in
some textbooks and publications. Common misconceptions
are to consider the change, exclusively, a hypersecretory
phenomenon, or a nonspecific regressive alteration
due to fetal death, trophoblastic disturbance, or
decreased hormonal levels (6,7). Some have, equivocally,
stated that “the occurrence of mitosis in carcinoma
and its absence in the Arias-Stella reaction is important
for the differential diagnosis” (8). This article summarizes
the most recent contributions to the literature, both
mine and those of other investigators, and attempts to
clarify the pathogenesis.
DEFINITION
The main characteristic of the reaction is cellular enlargement,
mainly of the nucleus, to double or many
times normal size. Without the presence of nuclear enlargement,
the phenomenon cannot be diagnosed. Hypertrophied
nuclei can show an ovoid or round shape with
granular or vesicular viable chromatin, an irregular outline
and a hyperchromatic appearance, or a compact,
pyknotic pattern (Fig. 1).
Mazur et al. (9) have used the term “optically clear
nuclei” to describe an aspect of the alteration, which is
characterized by centronuclear vacuolization resulting
from the replacement of the chromatin by a net of fine
filaments. Another morphologic variant is the occurrence
of intranuclear cytoplasmic invaginations—pseudoinclusions.
One or another of these alterations of the
macronuclei has been confused with herpetic endometritis
(10) (Fig. 2).
Usually the alterations are focal; they involve a group
of glands or only some part of them. Occasionally, they
can be quite extensive or “florid.” It is important to emphasize
that the presence of hypersecretory glands alone
does not constitute the phenomenon. The presence of
hypersecretory foci in the gestational endometrium was
described by Opitz (11) at the beginning of the last century.
HISTOLOGIC VARIANTS
Even though I originally described two forms of the
alteration (2) and later recognized a third form (12), accumulated
experience allows us to distinguish the five
histologic variants: 1) minimal atypia; 2) early secretory
pattern; 3) secretory or hypersecretory pattern; 4) regenerative,
proliferative, or nonsecretory pattern; and 5)
monstrous cell pattern. These variants are a function of
comparison with the phases of normal endometrium and
degree of atypicality.
Minimal Atypia
Minimal atypica is the pattern usually seen at the beginning
of gestation. The nuclear enlargement is minimal
and occurs in limited foci (Fig. 3). Because the decidual
reaction is absent or is not conspicuous in the early stages
of gestation, the diagnosis of minimal atypia may have a
special practical meaning. This is what we have found in
some women who have been evaluated for infertility
(Table 1).
Early Secretory Pattern
The early secretory pattern resembles normal early
secretory endometrium at day 17–18 of the menstrual
cycle. In these cases, nuclear enlargement is marked and
the endometrial cells show subnuclear or subnuclear and
supranuclear vacuoles (Fig. 4). The nuclei are centrally
>
