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- B1766Rare 乳腺分泌型癌 (cqz 13)
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44 y women with breast mass lesion
F1-2. 40x
F3-7 200x
F8-10 400x
You diagnosis or interpretation
标签：乳腺分泌型癌 s-100
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本帖最后由 于 2009-03-06 01:21:00 编辑
×参考诊断
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Secretory carcinoma of the breast.
Nineteen examples of a very rare type of carcinoma of the breast have been studied. The carcinoma is unusual in that it has exaggerated secretory features previously reported only (with one exception) in juveniles. But not all the patients in our series were juveniles; they ranged in age from 9 to 69 years (median age, 25 years). Six were 30 years of age or older. Eighteen patients were female and 1 was a 9-year-old boy. Treatment varied from local excision of the tumor to radical mastectomy. Four of the 11 patients who had axillary node dissection had metastatic deposits showing the same secretory features as the primary neoplasm. One of these 4 patients, a 25-year-old woman, died within ten months with disseminated tumor. Because this distinctive pattern of carcinoma is not limited to children and adolescents, we propose that it be called "secretory carcinoma." Since, of the 19 patients, 4 (21%) had axillary node metastases and 1 (5%) died with disseminated tumor, an extended simple mastectomy is recommended as the initial treatment for patients more than 20 years of age.
U can find the original paper to read if you are interested to the classification
Cancer. 1980 May 1;45(9):2404-13.
| 以下是引用cici在2009-3-6 20:39:00的发言：
不好意思，三种结构两种细胞中是哪两种细胞呀？ |
I assume that 有福不在忙 mean that
3 patterns: microcystic (honeycombed); more solid; tubular patterns.
2 cell types: Type A and Type B riginal described by Drs.Tavassoli and Norris at AFIP.
There are no a lot of meaning to calssify the cell types. Most of the cases are mixed with different growth pattern and cells. When you meet these kinds of cases, check the books and you will know the diagnosis.
In fact I do not know the patterns and cell types, until I read the book to answer your questions.
It is important for us to know and be familiar with the histologic featurs, but it is not important to remember some numbers.
| 以下是引用有福不在忙在2009-3-4 8:45:00的发言： 又仔细学习一遍，看来还是符合分泌癌的。我开始看胞浆不够丰富，嗜酸不明显，一下就把这个病给排除了。一叶障目，不见泰山啊 |
Congratulation.
This is an easy case for diagnosis. I showed here just becasue this ca is arare type. This case was one I had recut from AFIP when I worked there.
Wish my shandong 老乡 can give us a short summary of epideminology, clinical features, histopathology abd prognosis about the secretory carcinoma. Thanks,
Could I know which hospital you work now if you do not mind?
cz
