呵呵! 
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- B20Breast basal-like carcinoma (cqz 6)
| 以下是引用天山望月在2008-12-17 0:07:00的发言：
谢谢Dr.zhao无私奉献这么多好病例！ 反复仔细阅读这几例，深深领会，肿瘤的膨胀性、浸润性生长方式，不规则片状排列，胞界不清，浆少、多形性的瘤细胞，核细沙粒样，有核仁，易见核分裂，疤痕样胶原化，地图样坏死等特点。 |
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本帖最后由 于 2008-12-11 22:20:00 编辑
Gene expression profiling studies identified various breast carcinoma classes with prognostic significance. The 5 distinct classes indentified by expression progiling include 1)luminal A, 2)luminal B, 3)Her2 overexpression, 4) basal-like, 5) normal breast-like. Remember this classification was based on the many gene expression resutls. We can call them as genotypes of breast cancer.
Genotypes of Breast Cancer and Correponding Immunophenotype Markers
Genotype Immunophenotypic Marker
Luminal A ER+, and/or PR+, Her2-
Luminal B ER+, and/or PR+, Her2+
Her2 overexpressing ER-, PR-, /Her2+
Basal-like ER-PR-Her2-
positive for some markers
(CK5/6, EGFR, CK14, 17)
Normal breast-like No immunophenotypic marker
对不起，我突然发现有些打字错误，我再重述一下概念。
根据基因表达谱确定不同类型的乳腺癌有不同的预后意义。5个不同的亚型包括1）腺腔型A,2）腺腔型B,3）Her2 过表达型，4）基底样型，5）正常乳腺样型。要注意这种分类是根据很多基因表达的结果，我们称为乳腺癌的基因分型。
乳腺癌的基因分型和相应的免疫标记
基因分型 免疫标记
腺腔型A ER+, 和/或 PR+, Her2-
腺腔型B ER+, and/or PR+, Her2+
Her2过表达型 ER-, PR-, /Her2+
基底样型 ER-PR-Her2-，但其他一些标记阳性
(CK5/6, EGFR, CK14, 17)
正常乳腺样型 没有明确的免疫标记
| 以下是引用古城在2008-12-7 10:45:00的发言：
cqzhao 老师的回复： 看来你们很多人对这一类型的乳腺癌都有认识。我复习了一些文献，摘录了一些要点，供大家参考。 1、概念的来源： 用cDNA微阵列技术发现不同类型的乳腺癌，根据534个内源性基因的表达方式，乳腺癌可分为5个亚型：腺腔型A、腺腔型B、基底样型、Her2过表达型和正常乳腺样型。有兴趣的话，可看看以下文献： 2、免疫组化染色和基因微阵列之间的关系：根据肿瘤表达ER 和 Her2的情况。 肿瘤细胞表达ER者可分为：腺腔型A和腺腔型B两个亚型 肿瘤细胞不表达ER者可分为：基底样亚型、HER2过表达亚型、正常乳腺样亚型。 五个亚型概括为： 腺腔型A：ER+/Her2+ 腺腔型B：ER+/Her2- 基底样型：ER-/Her2- HER2过表达型：ER-/Her2+ 正常乳腺样型：ER- ...?
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I suddenly notice that I made a typing mistake about the classification. Sorry about this.
I describe the concept again
Gene expression profiling studies identified various breast carcinoma classes with prognostic significance. The 5 distinct classes indentified by expression progiling include 1)luminal A, 2)luminal B, 3)Her2 overexpression, 4) basal-like, 5) normal breast-like. Remember this classification was based on the many gene expression resutls. We can call them as genotypes of breast cancer.
Genotypes of Breast Cancer and Correponding Immunophenotype Markers
Genotype Immunophenotypic Marker
Luminal A ER+, and/or PR+, Her2-
Luminal B ER+, and/or PR+, Her2+
Her2 overexpressing ER-, PR-, /Her2+
Basal-like ER-PR-Her2-
positive for some markers
(CK5/6, EGFR, CK14, 17)
Normal breast-like No immunophenotypic marker.
很高兴看到一些中国关于基底样癌的研究：
Happy to see some study about basa-like ca in China
Hum Pathol. 2008 Feb;39(2):167-74. Epub 2007 Nov 28.
Basal-HER2 phenotype shows poorer survival than basal-like phenotype in hormone receptor-negative invasive breast cancers.
Liu H, Fan Q, Zhang Z, Li X, Yu H, Meng F.
Department of Pathology,
:Zhonghua Bing Li Xue Za Zhi. 2008 Feb;37(2):83-7.
[Morphological features of basal-like subtype invasive carcinoma of breast]
[Article in Chinese]
Gao LX, Yang GZ, Ding HY, Li L.
: Zhonghua Bing Li Xue Za Zhi. 2008 Feb;37(2):83-7.
[Morphological features of basal-like subtype invasive carcinoma of breast]
[Article in Chinese]
Gao LX, Yang GZ, Ding HY, Li L.
Department of Pathology, the General Hospital of Beijing Military Command,
是301医院吗？
你们可以找到这篇中文的文章读读。
我累了，希望能对你们有所帮助。
yes, it is 301 hospital. thankyou for the detailed explanation.
