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- 59 year old man with mastoid mass (ss112108)
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stevenshen 离线
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| 姓 名： | ××× | 性别： | 年龄： | ||
| 标本名称： | Mastoid biopsy | ||||
| 简要病史： | |||||
| 肉眼检查： | 1.0x0.8x0.6 cm | ||||
Great discussion and comments! I did not include cytology imprint pictures. I am surprised that nobody is asking for it. Here are two pictures of cytology - it might be useful to narrow down your differential diagnosis and immunohistochemical workup.
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本帖最后由 于 2008-11-30 05:15:00 编辑
×参考诊断
Large B cell lymphoma
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stevenshen 离线
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Differential diagnoses include lymphoma (including NK/T cell lymphoma), neuroendocrine carcinoma (including small cell carcinoma), peripheral PNET/extraskeletal Ewing sarcoma and rhabdomyosarcoma. I favor T cell lymphoma. AE1, Cam5.2, CD3, CD20, CD43, CD56 and/or CD57, CD79a, desmin, TTF-1 and synaptophysin would be my choices of initial IHC workup.
聞道有先後,術業有專攻
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stevenshen 离线
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| 以下是引用mjma在2008-11-29 7:57:00的发言： Differential diagnoses include lymphoma (including NK/T cell lymphoma), neuroendocrine carcinoma (including small cell carcinoma), peripheral PNET/extraskeletal Ewing sarcoma and rhabdomyosarcoma. I favor T cell lymphoma. AE1, Cam5.2, CD3, CD20, CD43, CD56 and/or CD57, CD79a, desmin, TTF-1 and synaptophysin would be my choices of initial IHC workup. |
谢谢mjma老师！
大致翻译如下：
鉴别诊断包括淋巴瘤（包括NK / T细胞淋巴瘤） ，神经内分泌癌（包括小细胞癌） ，周围原始神经外胚层肿瘤/Ewing肉瘤和横纹肌肉瘤。我倾向T细胞淋巴瘤。AE1, Cam5.2, CD3, CD20, CD43, CD56 and/or CD57, CD79a, desmin, TTF-1 and synaptophysin 将是我选择的初步免疫组化的工作。
- 广州金域病理
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stevenshen 离线
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- For small biopsy, touch prep imprint cytology should always be done before frozen section
- When suspicious for lymphoma, remember to save tissue for flow cytometric study, permanent H&E section, and other possibel studies
- Cytologic diagnosis is very valuable adjunct for the correct intraoperative frozen section diagnosis
- If possible, get patient's history from the surgeon before or during the surgery
Frozen diagnosis: atypical lymphoid proliferation, suspicious for lymphoma
Final diagnosis: Large B cell lymphoma (confirmed by flow cytometry)
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Please share your interesting frozen cases and lessons!
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shn-821128 离线
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