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- B1271请教，绒毛水肿？还是葡萄胎
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p57 interpretation is very tricky. The positivity of cytotrophoblasts means positive. Intervillous trophoblasts are always postive, and is used as internal control. Positive p57 is seen in non-molar villi or partial mole, excludes complete mole. Complete mole is negative for p57 in cytotrophoblasts and intervillous trophoblasts will be positive. So, positive p57 does not differentiate between partial mole or edema. The partial mole diagnosis must be based on other features. Chromosomal analysis confirms it (trisomy or other).
intervillous trophoblasts ：绒毛间滋养细胞？似乎不如绒毛外滋养细胞更确切。绒毛外的滋养细胞几乎全部由IT（intermediate trophoblast）组成，它浸润在蜕膜，子宫肌壁间和胎盘部位的螺旋动脉。根据IT所在部位的不同又将其分为绒毛IT（位于早期胎盘的绒毛柱）、种植部位细胞以及绒毛膜型IT。无论完全或部分性葡萄胎，还是流产绒毛退变水肿（也有称水肿性流产），IT均表达p57. 但完全性葡萄胎的绒毛上的滋养细胞阴性，而部分性葡萄胎的绒毛及流产后水肿的绒毛均为阳性。所以，p57无法用以鉴别流产后水肿绒毛和部分性葡萄胎。
- If you have great talents, industry will improve them; if you have but moderate abilities, industry will supply their deficiency. 如果你很有天赋，勤勉会使其更加完美；如果你能力一般，勤勉会补足其缺陷。
