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女,26岁,右乳肿块数年。
大体:最大径2.1cm乳腺组织,灰白,夹灰红小点。无牙膏状物。
全取,共4片。AB见导管内增生,CD为普通的乳腺增生症。
此为A片,免疫组化依次:SMA,p63,CK5/6,34βE12,ER,PR
(注:我们的CK5/6背景较强,染色淡黄者应视为阴性)
华夏病理/粉蓝医疗
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A) ADH
B) DCIS
B has some foci with real cribriform architecture and rigid round spaces. Cytologic atypia appears to be quite apparent to me in both A and B: large and monotonous nuclei, some appear to have nucleoli. Sorry i didn't examine the immunostained slides carefully because i was not differentiating between DCIS and invasive carcinoma.
Please note the cutoff line between UDH vs.ADH, ADH vs.DCIS is never clear and differ between pathologists.
liguoxia71 离线
以下是引用dhy在2008-7-28 20:03:00的发言:
abin您好!才看到这个病例! “ADH向低级别DCIS转化趋势(DIN 1b ~ DIN 1c)”是什么意思?? |
请丁教授指正:
我的理解,这个病例有明确的ADH,但是否足以诊断DCIS,很为难。对于难以明确性质的病变,既然宫颈可以允许CIN 2~3之类的诊断,乳腺病变也可以把诊断范围扩大一些吧。
加上患者年轻,病变又少,就不直接诊断DCIS了,退半步。
华夏病理/粉蓝医疗
为基层医院病理科提供全面解决方案,
努力让人人享有便捷准确可靠的病理诊断服务。
vitamin-xbl 离线