摘自：★Rosai and Ackerman’s Surgical Pathology  10th Ed (2 Vol Set) [PDF][tahir99] VRG

 摘自：Urologic Surgical Pathology 3rd Ed [PDF][tahir99] VRG

 A number of studies have proposed histologic criteria to predict malignant behavior. Hough and associates 281 reported

that the strongest predictors were broad fibrous bands, a diffuse growth pattern, and vascular invasion. Weiss and co-workers 284 analyzed the predictive value of nine histologic parameters and found that recurrence or metastasis occurred only in tumors with a mitotic rate greater than 5 per 50 hpf,atypical mitotic figures, and invasion of venous structures.

一些研究提出了组织学标准预测恶性行为。霍夫和同事281报道最明确的预测因数是宽阔纤维带，弥漫性生长模式和血管入侵.

考虑恶性， 免疫组化，再看看Ki67的指数如何

附件：肾上腺 

 嗜铬细胞瘤的胞浆不应该这么透明。

 最后诊断嗜铬细胞瘤。

包膜侵犯及血管内瘤栓一般不作为恶性依据。

 恶性嗜铬细胞瘤

 考虑为嗜铬细胞瘤，可见包膜侵犯及血管内瘤栓，建议随访观察。