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A number of studies have proposed histologic criteria to predict malignant behavior. Hough and associates 281 reported
that the strongest predictors were broad fibrous bands, a diffuse growth pattern, and vascular invasion. Weiss and co-workers 284 analyzed the predictive value of nine histologic parameters and found that recurrence or metastasis occurred only in tumors with a mitotic rate greater than 5 per 50 hpf,atypical mitotic figures, and invasion of venous structures.
一些研究提出了组织学标准预测恶性行为。霍夫和同事281报道最明确的预测因数是宽阔纤维带,弥漫性生长模式和血管入侵.