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肺穿刺

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楼主 发表于 2013-06-23 11:36|举报|关注(2)
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性别年龄63临床诊断
一般病史63岁,女,CT显示:右下肺结节性病变,恶性可能.补充病史:患者有胃粘液腺癌病史。
标本名称肺部穿刺标本
大体所见条形组织
  • 肺穿刺图1
    图1
  • 肺穿刺图2
    图2
  • 肺穿刺图3
    图3
  • 肺穿刺图4
    图4
  • 肺穿刺图5
    图5
  • 肺穿刺图6
    图6
  • 肺穿刺图7
    图7
  • 肺穿刺图8
    图8
  • 肺穿刺图9
    图9

 

标签:肺穿刺
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1 楼    发表于2013-06-23 22:26:50举报|引用
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片子的质量很棒!

最好调出来胃癌的切片复习对照看看,需要做免疫组化CDX-2、CK7、CK20、TTF-1;

形态上讲诊断:浸润性肠型腺癌没问题,形态结合病史倾向于转移。再看看IHC结果

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8 楼    发表于2013-07-13 12:43:14举报|引用
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肺原发性伴有黏液分泌的腺癌

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水若寒
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9 楼    发表于2013-07-15 22:13:36举报|引用
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 1、根据免疫组化的结果,考虑原发肺腺癌的可能性大;

2、可以免疫组化TTF-1和CDX-来2标记原来胃腺癌的片子,看看其免疫表型来对对肺部活检做判断。

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5 楼    发表于2013-06-24 21:18:35举报|引用
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引用 2 楼 水若寒 在 2013-06-23 22:27:41 的发言:

CDX-2-、CK7+、CK20-、TTF-1+

若果说是转移性腺癌,根据病史和形态结构,转移性胃的肠型腺癌比较合理联系。

但是,TTF-1阳性,而CDX-2阴性,不得不考虑肺原发性伴有黏液分泌的腺癌的可能性。

回头来,我们需要调研在胃肠道的腺癌有没有表达TTF-1阳性的腺癌,再说。

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6 楼    发表于2013-06-24 21:54:58举报|引用
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请看文献:

1)Strickland-Marmol LB, Khoor A, Livingston SK, Rojiani AUtility of tissue-specific transcription factors thyroid transcription factor 1 and Cdx2 in determining the primary site of metastatic adenocarcinomas to the brain. 2007 Nov;131(11):1686-90.

结果提示,Cdx2 和 TTF-1分别对判读转移性胃肠道腺癌和肺腺癌的价值是相等的。其特异性及阳性预测价值分别均为100%

Source

Abstract

CONTEXT:

Brain metastases of adenocarcinoma of unknown primary pose a diagnostic dilemma to the surgical pathologist. Although the most common source in these cases is the lung, determining a primary source is difficult on routinely stained slides. Immunohistochemical stain panels including differential cytokeratins, hormone receptors, and breast-specific proteins are commonly used in these cases. Recently, attention has turned to tissue-specific transcription factors, such as thyroid transcription factor 1 (TTF-1) and Cdx2, in the appraisal of metastatic adenocarcinomas.

OBJECTIVE:

To characterize the previously unpublished immunohistochemical expression of the relatively new tissue-specific transcription factor Cdx2 in metastatic adenocarcinomas to the brain.

DESIGN:

We reviewed the surgical pathology files of the H. Lee Moffitt Cancer Center and Research Institute, Tampa, Fla, and retrieved 38 consecutive cases of metastatic adenocarcinoma (22 pulmonary, 10 breast, 6 gastrointestinal [2 esophagus/gastroesophageal junction, 4 colorectal]) to the brain with confirmation of the primary site by chart review and histologic evaluation. Sections were immunohistochemically stained with antibodies to TTF-1, Cdx2, and cytokeratins 7 and 20 by standard methods.

RESULTS:

Specificities and positive predictive values for Cdx2 and TTF-1 equaled 100% for metastatic gastrointestinal and pulmonary adenocarcinomas, respectively. The negative predictive value of Cdx2 was also very high at 97%.

CONCLUSIONS:

Cdx2 is a specific and valuable tool for the surgical pathologist when faced with the common problem of metastatic adenocarcinoma of unknown primary. In conjunction with TTF-1, cytokeratin 7, and cytokeratin 20, Cdx2 can accurately differentiate the most common sources of metastatic adenocarcinoma to the brain.

2)Saad RS, Essig DL, Silverman JF, Liu Y.Diagnostic utility of CDX-2 expression in separating metastatic  gastrointestinal adenocarcinoma from other metastatic adenocarcinoma in fine-needle aspiration cytology using cell blocks.  2004 Jun 25;102(3):168-73.

结果显示,CDX-2 阳性核染色在胃肠道腺癌表达率为86%,而在其他部位的腺癌则CDX-2表达为阴性。 TTF-1在转移性胃肠道腺癌为0表达 (0%),而肺腺癌阳性率为80%。

Abstract

BACKGROUND:

CDX-2 gene is a transcription factor that is involved in the proliferation and differentiation of intestinal epithelial cells. Recent studies have shown that CDX-2 could be used as an immunohistochemical marker to differentiate metastatic gastrointestinaladenocarcinoma from other metastatic adenocarcinomas in surgical pathology. The objective of the current study was to investigate the diagnostic value of CDX-2 to separate metastatic gastrointestinal adenocarcinoma from other metastatic adenocarcinomas in fine-needle aspiration cytology (FNAC).

METHODS:

Sixty-two FNAC specimens of metastatic adenocarcinomas with corresponding cell blocks were retrieved from the hospital computer system. There were 22 specimens of metastatic gastrointestinal adenocarcinoma, 20 specimens of metastatic pulmonary adenocarcinoma, and 20 specimens of metastatic adenocarcinomas from other sites, including 10 from the breast, 3 from the ovaries, 4 from the pancreas, and 3 from the prostate. Radiology and histologic evaluation confirmed all cases. Sections were immunostained for CDX-2 and thyroid transcription factor-1 (TTF-1) using a heat-induced epitope retrieval technique.

RESULTS:

In metastatic gastrointestinal adenocarcinoma, CDX-2 demonstrated positive nuclear staining in 19 of 22 specimens (86%). Other specimens of metastatic adenocarcinoma were negative for CDX-2. TTF-1 expression was detected in 0%, 80%, and 0% of metastatic gastrointestinal adenocarcinoma, pulmonary adenocarcinoma, and other adenocarcinoma specimens, respectively.

CONCLUSIONS:

The results of the current study demonstrated that CDX-2 is a sensitive and a specific marker to separate metastaticgastrointestinal adenocarcinoma from other metastatic adenocarcinomas in FNAC specimens.

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2 楼    发表于2013-06-23 22:27:41举报|引用
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CDX-2-、CK7+、CK20-、TTF-1+

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3 楼    发表于2013-06-23 22:52:56举报|引用
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结合病史倾向转移

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4 楼    发表于2013-06-24 07:07:20举报|引用
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引用 3 楼 qiusuo 在 2013-06-23 22:52:56 的发言:

结合病史倾向转移


支持。

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7 楼    发表于2013-06-25 15:54:32举报|引用
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我考虑为肺转移性粘液腺癌,结合以前病史

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