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卵巢乳头状癌 Papillary carcinoma of ovary
Anemone cells: the presence of many microvilli in malignant cells is frequently documented by electron microscopy (EM), but their presence can be seen in some cases by optical microscopy as well. The use of Romanovsky stains can be very useful in this context ( I use to say they are the EM of the poor...). Spriggs and Boddington, in their classic book Cytology of effusions, Grune & Stratton, 1968, 2nd edition, were the first to call attention to this finding in papillary carcinomas of the ovary, with pictures remarkably similar to the ones in our cases. More recently, this finding has been called "anemone cells" and "anemone tumors" in relation to the cells or the tumors bearing them, respectively.
This case illustrates the difficult differential diagnosis between this type of tumor and mesothelioma, in special of the surface of the ovary and the pelvic peritoneum. Both tumors may exhibit windows between the cells, and microvilli in their surface. There is no immunochemistry test of real value, and the only certainty is done by the surgical exploration, as done in this case, where the pelvic peritoneum was free of disease, and the ovary had a typical serous cystadenocarcinoma papillary tumor. Their coelomic epithelial common origin explains their extreme similarities. Sometimes they both have ciliated cells besides microvilli in their surface.