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1 楼 发表于2006-11-10 11:56:00举报|引用
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The anatomic location, size and histopathology of this soft tissue tumor are classic for pleomorphic hyalinizing angiectatic tumor (PHAT) of soft parts. PHAT is a rare soft tissue neoplasm of unclear cellular origin (presumed to be related to neurilemmoma or schwannoma). It is considered to be a low grade malignancy - with potential for local recurrence after resection but not for distant metastasis. Characteristic histologic features include partially thrombosed and ectatic medium sized blood vessels, cirferentially hyalinized smaller blood vessels, spindled or stellate cells with occasional giant forms, and focal collection of cells containing cytoplasmic hemosiderin. Although thin encapsulation at its periphery has been reported, my personal limited experience with this tumor is that many are not encapsulated and can have infiltrative borders. This is especially true for the so-called "early" PHAT recently described. Early PHAT are more cellular, myxoid, and less pleomorphic.
The anatomic location, size and histopathology of this soft tissue tumor are classic for pleomorphic hyalinizing angiectatic tumor (PHAT) of soft parts. PHAT is a rare soft tissue neoplasm of unclear cellular origin (presumed to be related to neurilemmoma or schwannoma). It is considered to be a low grade malignancy - with potential for local recurrence after resection but not for distant metastasis. Characteristic histologic features include partially thrombosed and ectatic medium sized blood vessels, cirferentially hyalinized smaller blood vessels, spindled or stellate cells with occasional giant forms, and focal collection of cells containing cytoplasmic hemosiderin. Although thin encapsulation at its periphery has been reported, my personal limited experience with this tumor is that many are not encapsulated and can have infiltrative borders. This is especially true for the so-called "early" PHAT recently described. Early PHAT are more cellular, myxoid, and less pleomorphic.
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