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I cannot read the picture very well. My impression is that there is focal moderate nuclear atypia. I am not so sure the "necrosis" is true tumor necrosis only based on these photos. You need make sure the necrosis is tumor necrosis, not infarct-like necrosis. Also you need count mitotic figures to give a actual number of how many MF/10 high power fields. I do not think this is a diagnosis I can render just based on couple photos without looking the real slides. I did not see any "bizarre nuclei" in the photos provided. If you have any bizarre nuclei, you want to exclude bizarre leiomyoma before rendering leiomyosarcoma.
以下是引用曲直在2011-3-1 9:39:00的发言:
诊断子宫平滑肌肉瘤的组织学标准: 1、坏死,2、分裂像;3、细胞异型性;4、浸润;5、转移 只要有真正的凝固性坏死即可诊断。 分裂像带有主观因素。 有细胞异型性不一定是恶性,如奇异性平滑肌瘤。 有浸润也不一定是恶性,如静脉内平滑肌瘤。 有转移也不一定恶性,如转移性平滑肌瘤。 所以要综合分析,本例见到坏死,富有细胞,细胞有异型性,可见分裂像,够肉瘤了。 |