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- 24 yr old woman with low level proteinuria.
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| 姓 名： | ××× | 性别： | Woman | 年龄： | 24 |
| 标本名称： | Kidney needle biopsy | ||||
| 简要病史： | Patient is a young woman with low level proteinuria. All serology tests are negative. Her aunt and uncle also have kidney disease. The sample submitted for immunofluorescence (IF) stains contains 2 glomeruli. All IF stains are negative. | ||||
| 肉眼检查： | |||||
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本帖最后由 于 2010-11-14 10:39:00 编辑
×参考诊断
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本帖最后由 于 2010-12-07 12:05:00 编辑
| 以下是引用海上明月在2010-11-25 14:13:00的发言： 需要鉴别遗传性肾病和隐匿性局灶节段性肾小球硬化。 I also think about 遗传性肾病. Because there are subendothelial electron dense deposits, 局灶节段性肾小球硬化 is ruled out. My differential diagnosis includes fibronectin glomerulopathy. But I do not have the antibody to prove these deposits to be fibronectin.I have sent the frozen tissue to outside institution for identification of these deposits. Hopefully I will have answer soon. |
| 以下是引用huangsinian1983在2010-12-2 21:03:00的发言： 是不是alport's 肾病？ The characteristic ultrastructural change of alport's 肾病 is thinning of glomerular basement membrane with splitting. The current case shows massive subendothelial and mesangial electron dense deposits. Clinically alport's 肾病 have hematuria. The above patient has proteinuria. |
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本帖最后由 quhong 于 2011-08-25 23:04:12 编辑
The material I sent out to Mayo Clinic is too small. No way they could perform any test on it. The immunofluorescence microscopy is negative for albumin, fibrinogen, C1q, C3, C4, IgA, IgG, IgM, kappa and lambda light chains. Fibronectin nephropathy is the most likely diagnosis.
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