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5 楼 发表于2010-11-03 12:16:00举报|引用
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The photos do suggest a case of pleomorphic xanthoastrocytoma. Please search for eosinophilic granular bodies and perivascular inflammation on sections carefully. If both are present the diagnosis is WHO grade II PXA. In addition, mitotic count is very important because very rare cases of PXA behave more aggressively and their only atypical histologic features are increased mitotic activity and focal tumor necrosis. Of course, one important differential diagnosis is giant cell variant of glioblastoma.
The photos do suggest a case of pleomorphic xanthoastrocytoma. Please search for eosinophilic granular bodies and perivascular inflammation on sections carefully. If both are present the diagnosis is WHO grade II PXA. In addition, mitotic count is very important because very rare cases of PXA behave more aggressively and their only atypical histologic features are increased mitotic activity and focal tumor necrosis. Of course, one important differential diagnosis is giant cell variant of glioblastoma.
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