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姓 名: | ××× | 性别: | 女 | 年龄: | 30岁 |
标本名称: | 右腋下肿块 | ||||
简要病史: | 发现右腋下肿块1年,逐渐增大。双侧乳房无肿块。腋下肿块于真皮下。表皮无溃破。其它处未发现肿瘤。 | ||||
肉眼检查: | 不规则组织,局部见肿块1.7X |
以下为术中冰冻切片的HE图片
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以下是引用cqzhao在2010-9-17 10:44:00的发言:
ER/PR strongly positive and also 肿块周边见乳腺腺病结构,并与其旁汗腺导管明显对比. So it is invasive ductal carcinoma or invasive tubular ca depending the percentage of tubular structure. Because 肿块周边见乳腺腺病结构,we will favor the tumor arises from 副乳腺. Clinical correlation with imaging study is suggested. Pathologists do not need to say it must be from 副乳腺tissue. Intersting thing is the her2 stain. Clearly this is a low grade carcinoma. Generally these kinds of tumors are ER/PR strongly positive and negative for Her2. I do not know the positive and negative control for the stain. It is difficult to say the score is 3+. If it was my case, I may just call score 2 and do a FISH for her2. Her2 result (positive or negative ) is too important for clinical judgment for treatment. |
谢谢赵老师精辟点评!
赵老师点评:
此例冰冻诊断有困难:图片显示,致密间质内腺体不规则。有些腺体无肌上皮环绕。很有可能是浸润性导管癌伴有小管形态。当然,仅根据图片,本人不能100%肯定它就不是良性(特别是发生在这个罕见的部位)。本人可能要到看了实际切片时,才确认是癌。
现场冰冻如果不能确诊,无论如何只能是将其延缓报告(待石蜡切片),并告诉手术医生几个鉴别诊断以及倾向性诊断。要让外科医生知道,有待石蜡切片再做些工作,才做最后诊断。底线是本例冰冻报告结果(良或恶性)并不会改变马上的临床处治。当然, 如果冰冻时觉得有信心诊断,那也可确诊。
建议石蜡切片标记肌上皮标志物和ER、PR(证实乳腺起源)。
需知腋窝异位乳腺组织可发生纤维腺瘤和浸润癌。
希望知道后续结果。