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liguoxia71 离线
junzi003981 离线
如果整张涂片观察Calretinin呈局灶阳性,Ber-EP4强阳性,就考虑肺腺癌;如果整张涂片Calretinin为阴性,则考虑乳腺癌,肺腺癌和乳腺癌的鉴别还应该给予TTF-1,CK5/CK6。
从形态学上看,液基细胞中因为制片的技术原因细胞会被打散分布,但上述几张传统离心涂片中腺癌细胞之间是分散存在,查了一些资料这是讲细胞分散型肺腺癌的----以散在为主分布的细胞分为两种,以中等大小体积的腺癌细胞和混杂有多数量的巨大细胞即瘤巨细胞类型。讲乳腺癌的是---乳腺小叶癌的胸腔积液中,大部分细胞散在分布,核呈半月型或印戒样。
从赵老师的帖子里会学到很多知识,就算发言错了,最终我还是能增长自己的知识,所以我不怕丑的,请赵老师多指正。
Thank your explanation.
如果整张涂片观察Calretinin呈局灶阳性,Ber-EP4强阳性,就考虑肺腺癌;如果整张涂片Calretinin为阴性,则考虑乳腺癌. Above is not correct. Both lung and breast cancers (almost all epithelial tumors) are positive for Ber-EP4 and negative for calretinin. Ber-EP4 and calretinin are only used for distinguish epithelial cells from mesothelial cells. They cannot tell the origins and the nature of the cells (benign or malignant). Of cause generally speaking if you find epithelial cells in 腹水 或pleural fluid are metastatic tumors. Above are basic stain priniciple in fluid IHC. for your reference |