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liguoxia71 离线
Prof Yang: Would you please explain the role of IgH, p63, cyclin E and ki-67 in differential diagnosis of epithelial trophoblastic tumor (ETT), atypical placental site nodule and PSTT?
Thank you!
(Prof Yang:请讲解IgH, p63, cyclin E 和ki-67对ETT、不典型胎盘部位结节和PST的鉴别诊断作用。谢谢! abin译)
这个病例的诊断: 胎盘部位结节 (placental site nodule)
胎盘部位结节有以下特点:
(1) 是小的, 红红的小结节eosinophilic,偶尔见于子宫活检或刮宫. 偶尔多个结节(比如这个病历)
(2) 见于生育年龄, 来源于中间滋养细胞
(3) 有些病人的孕史很遥远. 有些是流产了.
(4) 喜欢位于宫颈和子宫下段
(5) 镜下: 边界清楚, 结节样, 背景是红红的透明样基底eosinophilic hyalinized stroma/background, 结节周围可以见一些慢性炎性细胞. 细胞核可以深染不规则但是那种退化性的(degenerative), 可以见核分裂相败涂地但KI67 < 10%. 细胞底透明或红红的 (clear or eosinophilic), 细胞大小不一
(6) 大家可以观察一下胎盘的绒毛膜的中间滋养细胞, 胎盘部位结节的细胞跟绒毛膜的中间滋养细胞一样, 因为胎盘部位结节来源于绒毛膜的中间滋养细胞.
(1) 胎盘种植部位中间滋养细胞 -à 对应的肿瘤或瘤样病变: 胎盘部位过渡反应(exaggerated implantation/placental site, 胎盘部位滋养细胞肿瘤placentals site trophoblastic tumor,
(2) 绒毛膜中间滋养细胞à à 对应的肿瘤或瘤样病变: 胎盘部位结节 placental site nodule, 上皮样滋养细胞肿瘤epithelioid trophoblastic tumor
(3) 绒毛中间滋养细胞 à对应的肿瘤: 绒癌choriocarcinoma的一部分.
病史是重要, 有时候也得不到, 有时候不需要就可以诊断. 当然看图做诊断和看片子做诊断是不一样的. 所以我不会设陷阱的. 当然这个病人也没有其他的肿瘤或者异常的影象学表现.
下个贴子再谈免疫组化.
Dr. Cao,
Nice case and great teaching notes. I learn sth here. This case reminds me of a recent case of mine. It looks similarly cellular. When i did Ki-67 which is between PSN and ETT. I sent to Drs. Kurman and Ie-Ming who agree with my diagnosis of "atypical PSN". I am curious of the ki-67 labelling in this case since it is little on the cellular side.
Bin
(病例好,讲解也好,我也学习了。此例使我想起我最近的一个病例。它看上去细胞丰富程度相似。Ki67免疫染色介于PSN和ETT之间。送给Drs. Kurman 和Ie-Ming会诊,他们同意我的诊断“不典型PSN”。鉴于细胞丰富程度的诊断价值很小,我想知道此例Ki67标记的情况。 abin译)
以下是引用杨斌在2007-9-19 10:12:00的发言:
Dr. Cao, Nice case and great teaching notes. I learn sth here. This case reminds me of a recent case of mine. It looks similarly cellular. When i did Ki-67 which is between PSN and ETT. I sent to Drs. Kurman and Ie-Ming who agree with my diagnosis of "atypical PSN". I am curious of the ki-67 labelling in this case since it is little on the cellular side. Bin
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lfl001200546 离线