Palisaded Myofibroblastoma

• Mostly inguinal lymph node, solitary and painless

• Benign, rarely recurs

• Micro:

  • Palisading spindle cells, no nuclear atypia, rare mitoses

  • Amianthoid bodies:  homogeneous eosinophilic collagen deposit, fine hair-like spokes, peripheral granular weakly eosinophilic area. Trichrome stain +

  • Hemorrhage, hemosiderin deposit

• IPX: SMA+, myosin+,  vimentin+; desmin-, Factor VIII -, S100-, synaptophysin-

• DDX:

  • Kaposi sarcoma: no Amianthoid bodies, but shows endothelial clefts, RBC extravasculation, inflammatory cells, and HHV8+

  • Schwannoma: no Amianthoid bodies, but shows Antoni A and B patterns, thick-walled vessels, and S100+

  • Spindle cell sarcoma: atypia, mitosis and lack of Amianthoid bodies

• Benign, rarely recurs

• Micro:

  • Palisading spindle cells, no nuclear atypia, rare mitoses

  • Amianthoid bodies:  homogeneous eosinophilic collagen deposit, fine hair-like spokes, peripheral granular weakly eosinophilic area. Trichrome stain +

  • Hemorrhage, hemosiderin deposit

• IPX: SMA+, myosin+,  vimentin+; desmin-, Factor VIII -, S100-, synaptophysin-

• DDX:

  • Kaposi sarcoma: no Amianthoid bodies, but shows endothelial clefts, RBC extravasculation, inflammatory cells, and HHV8+

  • Schwannoma: no Amianthoid bodies, but shows Antoni A and B patterns, thick-walled vessels, and S100+

  • Spindle cell sarcoma: atypia, mitosis and lack of Amianthoid bodies

Reference:

• Ioachim's Lymph Node Pathology, 4th edition

 学习尝试翻译：

Hemorrhagic spindle cell tumor with amianthoid fibers (Pallsadinded myofibroblastoma).

伴有石棉样纤维的出血性梭形细胞肿瘤（栅栏状肌纤维母细胞瘤）

Intranodal palisaded myofibroblastoma with "amianthoid" fibers

结内栅栏状肌纤维母细胞瘤伴石棉样纤维