Lymph node_2 - 华夏病理网论坛

Lymph node_2

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×参考诊断

Palisaded Myofibroblastoma

Final diagnosis:

Palisaded Myofibroblastoma

Micro:

Palisading spindle cells, no nuclear atypia, rare mitoses
Amianthoid bodies: homogeneous eosinophilic collagen deposit, fine hair-like spokes, peripheral granular weakly eosinophilic area. Trichrome stain +
Hemorrhage, hemosiderin deposit

IPX: SMA+, myosin+, vimentin+; desmin-, Factor VIII -, S100-, synaptophysin-

DDX:

Kaposi sarcoma: no Amianthoid bodies, but shows endothelial clefts, RBC extravasculation, inflammatory cells, and HHV8+
Schwannoma: no Amianthoid bodies, but shows Antoni A and B patterns, thick-walled vessels, and S100+
Spindle cell sarcoma: atypia, mitosis and lack of Amianthoid bodies

Benign, rarely recurs
Micro:
- Palisading spindle cells, no nuclear atypia, rare mitoses
- Amianthoid bodies: homogeneous eosinophilic collagen deposit, fine hair-like spokes, peripheral granular weakly eosinophilic area. Trichrome stain +
- Hemorrhage, hemosiderin deposit
IPX: SMA+, myosin+, vimentin+; desmin-, Factor VIII -, S100-, synaptophysin-
DDX:
- Kaposi sarcoma: no Amianthoid bodies, but shows endothelial clefts, RBC extravasculation, inflammatory cells, and HHV8+
- Schwannoma: no Amianthoid bodies, but shows Antoni A and B patterns, thick-walled vessels, and S100+
- Spindle cell sarcoma: atypia, mitosis and lack of Amianthoid bodies

Reference:

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