Peripheral T-Cell lymphoma, Lymphoepithelioid Variant

(Lennert Lymphoma)

• Micro:

  • Often diffusely replaces the lymph node architecture

  • Numerous epithelioid histiocytes in small clusters or linear rows

  • The neoplastic T-cells are small without significant atypia

• IPX: tumor cells usually CD8+

• DDX:

  • Sinusoidal histiocytosis: well-preserved architecture of lymph node with expansion of sinus

  • Sarcoidosis: well-formed, non-caseating granuloma, the remaining lymph node architectures is preserved

Reference:

• Ioachim's Lymph Node Pathology, 4th edition

• WHO Classification of Tumors of Hematopoietic and Lymphoid Tissues, Fourth Edition. 2008.

 Lennert lymphoma