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nfykdx2008 离线
lantian0508 离线
以下是引用xljin8在2010-8-22 7:24:00的发言:
这是一例非常好的讨论和学习病例,诊断比较困难,会有分歧。
鉴别诊断还是要围绕:
1)前列腺腺病; 2)前列腺部分萎缩; 3)前列腺腺癌; 4)IHC标记结果的判断;
谢谢张主任提供的好病例! |
小结:
1)对于前列腺穿刺活检中见到小灶异型(5个)/或不典型腺体时,诊断非常困难,经常会有不同意见。病理医生要结合临床综合考虑,并做IHC进行鉴别,如果还不能确定,最好请有经验的专家会诊。
这种情况在日常实践中碰到的几率约为3%,其中50%经IHC标记和专家会诊能明确诊断,但仍有1.5% 的病例仍不能确定。
2)对于极少数不能明确诊断的病例,可选择密切随访或再次活检。因为在相当长的时期内, 推迟诊断并不对病人的治疗和预后造成影响,所以防止诊断过度比诊断不足更重要。尤其在目前的医疗环境下,要非常注意医疗安全。
medman_2010 离线
The tumor was arranged with irregular gland, which destroied the smooth cell. The neoplastic cells have abundant foam-like cytoplasm. The nuclear is obviously atypia but have no prominent nucleoli.
Based on these morphologic features, i consider it as a prostate adenocarcinoma.
It is necessary to use a panel of antibodies to comfirm the diagnosis.
By the way, the growth pattern is so important during prostate pathologic diagnosis. The last figure give us a actively proliferation impression but not atropy. So i favor adenocarcinom
zhanghuadong 离线
cancan8680 离线