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肉眼检查: |
60 y/f with history of breast ca and had segmental mastectomy sereral years ago in other hospital. Patient present with pleural effusion.
F1. ThinPrep 400x
F2. cell block 400x
F3-4. cell block 600x
What will you do?
First step:
I always do some stains for these kinds of fluid cytologic cases to distinguish mesothelial cells from epithelial cells first.
Calretinin (mesothelial) and BerEP4 (epithelial)are the best two markers to choose.
以下是引用笃行者在2010-1-1 21:19:00的发言:
对细胞学不是太熟悉,但感觉这些细胞核较大,核浆比增大,染色质较粗,核仁明显,有核分裂像,考虑是癌细胞。期待Dr.zhao解惑,谢谢! HAPPY NEW YEAR TO YOU, Dr.Zhao. |
We sent message here in the same time. You just did a few second before me.
Happy New year to you too. Thank you I learned the new word "笃" in 2009. cz
以下是引用cqzhao在2009-12-31 11:21:00的发言:
This is my last case in 2009. Thank all people who read and/or attended discussion for these cases. HAPPY NEW YEAR FOR ALL OF YOU. CZ |
HAPPY NEW YEAR TO YOU,Dr.Zhao.
这例在血细胞、炎症细胞的背景下,可见增生的间皮细胞。需要关注的是,极少的核膜增厚的染色质增粗的核仁增大的细胞,可能是问题细胞。建议利用细胞块做IHC标记D2-40、TTF-1等间皮与腺标记物,以鉴别。