Though I did not see tumor necrosis or apparent mitotic figures in neoplastic cells, the cytologic pleomorphism and vascular/endothelial proliferation, GFAP immunoreactivity and cytokeratins immunoreactivity are most consistent with a WHO grade IV glioblastoma and not metastatic malignancy (of ovarian or other possible origins).
Though I did not see tumor necrosis or apparent mitotic figures in neoplastic cells, the cytologic pleomorphism and vascular/endothelial proliferation, GFAP immunoreactivity and cytokeratins immunoreactivity are most consistent with a WHO grade IV glioblastoma and not metastatic malignancy (of ovarian or other possible origins).