57 y AA women/L ov mass 8x6x4 cm. This is the AFIP case in Jan 1974. Dr. Henry J Nosrr was Chair of Gynecology/breast Department at AFIP. He and his colleques reviewed the case, and also sent the case to MGH for second oppinion. The case was reviewed by Dr. Robert E. Scully and Dr. Stanley J. Robboy. I found the case in 2004 for immunostain research of ovarian sex cord stroma tumors and noticed their original interpretation for this case.Remember that there were no immuno atains in 1974. They had different oppinion and no final conclusion about this case.

I would like to share this case with our Chinese pathologists.

1. Know how difficult for some cases if there is no immunostain

2. To learn the concept of these world leading pathologists.

3. Hope our patholgoists know these greast pathologists. Welcome some ones to write some brief introduction for these pathologists,Robert E. Scully, Henry J Nosrr, Stanley J. Robboy. All of them are alive

4. Try yourself and you may have a better diagnosis than these experts. Ha, ha.

cz

 In 2004, I did the research project of IHC of ovarian sex cord stromal tumor at AFIP and  found this case.

I did many stains and showed you some in the following

 Inhibin: more than 90% cases of sertoli cell tumor, positive

calretinin: 40-60% SCT positive

名称：图1
描述：图1

名称：图2
描述：图2

 Chromgranin

Synaptophysin

Almost all carcinoid cases are positive.

A few percentage of SCT can be focally or weakly  positive.

名称：图1
描述：图1

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描述：图2

 I once showed the case in  a talk at UPMC 1n 2006. Austin, who worked three years at AFIP with Dr. Norris in the late of 1980s, told the story to Norris. Norris sent an email back with a good humor " finally I made one case correctly after 32 years"

The purpose I showed this case is to demonstrate the ovarian sex cord tumor is a large family of tumors exhibiting varying degrees of differeentiationa and pathologic features. Some cases are difficult to make the dx for pathologists, even for the expert pathologists. The importance is that you should have the differnetial diagnoses and some basic knowledge of immunostains.

 两性细胞瘤

Thanks.

It is not cost-effect.

象类癌