学习了，长见识。

没看懂，学习。

 继续学习并提出几个疑问：

1、国人新生儿的肾上腺最大径可以超过3cm，本例最大径4cm，是否也在允许范围？

2、新生儿可以有肾上腺出血坏死，本例会不会是一种“超常”反应？出血坏死后，继发组织细胞反应、钙化等图中所见改变？

3、能否提供免疫组化图像？看看哪些细胞CD68阳性？那些胞浆深嗜酸性的细胞表达什么抗体？

4、S-100阴性？似乎不好解释。

欣赏肾上腺巨细胞症（anrenal cytomegaly）这个诊断.

查过一些文献,这个诊断好!

liguoxia71医生不简单,更欣赏这个座右铭:三人行,必有我师焉,择其善者而从之,其不善者而改之。自勉.

在读我的意见之前，要知道我不是儿科病理学者，对婴儿肾上腺组织学知识掌握的也有限。下面我引用的是Stephen Sternberg撰写的第二版病理医生专用组织学中的一段话（1110页）：妊娠末期，胎儿临时皮质成分占腺体大部分。出生后几小时内，临时的皮质成分开始明显充血、变性。7-10天后，开始变得结构紊乱、坏死。周围细窄带内的细胞团存活并成为以后永久皮质的来源。看来出生后2周内胎儿皮质有坏死是可以的。所以，这个年龄，皮质部位有坏死是正常发育过程，不一定是肿瘤性坏死。前8张图可能显示了这一正常生理过程。当然，这仅是我个人观点，你们不必太当真。免疫组化结果解释困难，它标出了2种成分-T淋巴细胞和巨噬细胞，是否是坏死的主要反应细胞？CD31主要是标记内皮细胞的，是不是我们想的那样显示了血管着色？我们需要有儿科病理知识的病理学者来解释这个病例。（liguoxia试译）

Before you read my following comment, I would like you to keep this in mind. I am not a pediatric pathologist, with only limited knowledge of baby adrenal gland histology.
Here is a paragraph I quoted from "Histology for Pathologist" (2nd edition), a book written by Stephen Sternberg.
  "At the end of gestation, the provisional cortex accounts for the bulk of the gland. Within hours of birth, it becomes acutely congested and starts to degenerate. At the end of 7 to 10 days, the provisional cortex is largely disorganized and necrotic. The narrow peripheral band of cell clusters survives and becomes the source of the permanent cortex" (page 1110).
It seems that the provisional cortex or fetal cortex is supposed to have necrosis in two weeks after birth. Therefore, at this age, the necrosis within the cortical location is a normal process, not necessarily a tumor necrosis.  The above first 8 photos probably demonstrate this normal process. Of course, this is my personal opinion. You don't need to take it too seriously.
The immunohistochemical results are difficult to interpret. They highlight two populations of cells: T-lymphocytes and macrophages. They are the major cells reactive to necrosis, aren't they?  CD31 is primarily an endothelial marker. If CD31 stains vessels, that is what we expected.  We need a pathologist with pediatric pathology background to explain this case.

 肾上腺巨细胞症(adrenal cytomegaly) 。

据说 肾脏异常；可能有结构性异常、肾脏肿大与肾 结石 颚裂

肾上腺巨细胞症 的具体情况， 还要查资料。