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- B2192求助：乳腺癌的免疫组化分级
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jiajing1115 离线
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请各位老师帮忙解答：乳腺癌免疫组化比如ER,PR,C-erb2等分级+、++、+++的判断标准是什么呢，是看阳性率的百分之多少而界定的呢？现在的报告要求给出几个加号还是要给出百分比呢？谢谢
标签：乳腺癌 组化标记 评分标准
×参考诊断
1. Her2 You can find detailed discussion with some photos in the following topic
http://www.ipathology.com.cn/forum/forum_display.asp?keyno=128105
Her2 result is very important for prognosis and treatment. In the USA people use the same score (CAP) system in almost all the hospitals
Brief desc ription about the scores
Tissue fixed using formalin 8-96 hours.
0 = No staing is observed or membrane staining is observed in less than 10% of the tumor cells.
1+ = A faint/barely perceptoble membrane staining is detected in more than 10% of the tumor cells. The cells are only stained in part of their membrane
score 0, 1 called negative
2+ = A weak to moderate complete membrane staining is observed in more than 10% of the tumor cells.
2+ means equivocal
3+ = A strongly complete membrane staining is observed in more than 30% of the tumor cells.
3+ means positive.
2. ER, PR: You can use intensity (strong, moderate, weakly) and extension (diffuse, focal) to describe the stains.
Also you can use some semiqualitative system, give some score. We use H score system for ER, PR. The highest H score is 300.
Anyway there is no good standard for ER/PR reporting.
Hope it can help.
cz
