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- gangliocytoma or ganglioglioma
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Journal of Neuropathology & Experimental Neurology Volume 61(7), July 2002, p 575-584 Gangliogliomas: An Intriguing Tumor Entity Associated With Focal Epilepsies
BLUMCKE, INGMAR MD; WIESTLER, OTMAR D. MD
neuronal phenotype (cortical dysplasias, gangliocytomas) towards variants with a
prominent glial population (diffuse astrocytomas) (Figs. 2, 3). However, these
tumors may also display a clear cell morphology, which raises the differential
diagnosis of oligodendroglioma or DNT. The specific immunohistochemical profile
of gangliogliomas will usually allow a greater distinction (see below).
Fig. 2. The spectrum of gangliogliomas and its differential diagnosis.
CD34, MAP2 and Ki67 are immunohistochemical reactions. Note that MAP2 immunoreactivity
(MAP2 +) refers only to glial (neoplastic) cell elements.
Fig. 3. Histopathological findings in gangliogliomas. The histopathological
spectrum of gangliogliomas includes patterns with a predominant neuronal
phenotype (A, B) as well as tumors with a prominent glial element (D-F).
Dysplastic neurons may manifest in small clusters but can also be observed
adjacent to the mass tumor (C). Note the morphological similarity of regions
depicted in (D) with fibrillary astrocytomas and in (E) with oligodendrogliomas.
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本帖最后由 于 2006-10-09 11:41:00 编辑
- the more we discuss, the more we learn from each other !!
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文献报道DNT中胶质细胞 Ki-67的阳性率为0－0.8%，严格说来应该是阴性，图中所示K1－67和CD34均为阴性（注意标点符号），MAP-2也为阴性。
以下为文献摘要的一部分：
Histopathological characteristics of the DNTs included the specific glioneuronal elements (the mixture of OLCs and neurons) in four cases, alveolar pattern (all cases), microcystic degeneration (all cases), multinodular architecture (four cases), and adjacent cortical dysplasia (all cases). Immunohistochemically, Ki-67 labelling indices ranged from 0 to 0.8%. OLCs were positive for glial fibrillary acidic protein in two cases, for S-100 protein in all cases, for synaptophysin in two cases, and for class III beta tubulin in all cases. Pathological features of our cases were characterized by its heterogeneous histological appearances and divergent cellular differentiation.
- the more we discuss, the more we learn from each other !!
