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肉眼检查: |
about 60 y/f, right breast mass 2 cm by imaging, breast core biopsy.
1. Your differential diagnosis?
2. What will you do next?
Please do not just give a diagnosis. Your dx is a guess dx even though your diagnosis may be right.
As pathologists we should learn how to analyse our cases with logic thought.We should have differential dx for all cases in our mind even for the easy cases. We can use available sources (such as IHC, molecular methods, history, consultation) to rule in or rule out the differential dx, then make the final dx.
Learning the priniciple for diagnosis is much more important than learning a few cases.
如果我遇到这样的病例,我的第一印象是:梭形细胞化生性癌---可以用CK7、CK8/18等确定其上皮性质;周围可能有原位癌成分;另外,梭形细胞癌也常标记肌上皮标记物(如P63、S-100、calponin等故需注意与肌上皮癌鉴别)。
当然一定要有其他鉴别诊断:1、恶性叶状肿瘤---寻找良性上皮成分;梭形细胞CK阴性而Vimentin阳性;或可有异源性分化(如骨、肌源性分化等)。2、乳腺间质肉瘤。3、乳腺非特异性软组织肉瘤。……
期待Dr.zhao的结果与分析。
以下是引用zrj711在2009-5-7 19:44:00的发言: 160;化生性癌吗?需要更多证据低倍图呢! |