Good morning, my colleagues:

This is an interesting case of breast lesion.  I would like to share with you for educational purpose.  My fellow and I will publish a short review of this entity in the future issue of Archives of Pathology and Laboratory Medicine. 

This is a 54-year-old female with history of breast nodule measuring 2.5 x 2 x 1.8 cm.  Skin over the nodule shows crusting and ulceration.  Mammography demonstrates a mass in the subareolar region with dense and irregular outline, spicular formation and foci of microcalcifications. Ultrasonography shows an ill-defined mass with heterogeneous internal echoes. Radiographic findings suggest malignancy.

形态符合乳头腺瘤

Good morning, my colleagues:

This is an interesting case of breast lesion.  I would like to share with you for educational purpose.  My fellow and I will publish a short review of this entity in the future issue of Archives of Pathology and Laboratory Medicine. 

This is a 54-year-old female with history of breast nodule measuring 2.5 x 2 x 1.8 cm.  Skin over the nodule shows crusting and ulceration.  Mammography demonstrates a mass in the subareolar region with dense and irregular outline, spicular formation and foci of microcalcifications. Ultrasonography shows an ill-defined mass with heterogeneous internal echoes. Radiographic findings suggest malignancy.

名位同行，早上好：

   这是一例有趣的乳腺病例，做为教学目的我想与你们分享这一病例。我与我的进修生将在下一期Archives of Pathology and Laboratory Medicine杂志上发表一篇这种病变的短的回顾性研究。

    这是一个54岁的女性，乳腺有一2.5*2*1.8cm肿块。肿块表面皮肤溃疡、结痂。乳房影像学显示在乳晕下区域有一边界不规则的高密度肿块，毛刺状外形，灶性微钙化。超声检查显示一内部回声不均质的界限不清楚的肿块。放射学结果考虑恶性肿瘤。

搬个马扎学习......

 谢谢Dr.quanxun

我也考虑乳头部腺瘤。

 I think it is a Syringomatous adenoma of the nipple. Correct me if I am wrong.

Thank for sharing the interesting case.

Waiting for your final dx.

 翻译楼上：

我考虑乳头汗管瘤样腺瘤。如果错了给我纠正。谢谢分享这一有趣病例！期待最后结果。

 Syringomatous adenoma of the nipple

同意。

    You are all very good.  What is the differential diagnosis?

 谢谢，非常好的病例，再次学习并同意“乳头的汗管瘤样腺瘤syringomatous adenoma of the nipple”，同义词“浸润性汗管瘤样腺瘤infiltrating syringomatous adenoma”。

鉴别诊断包括：

浸润癌（小管癌和低度恶性腺鳞癌）、乳头部腺瘤or旺炽性乳头状瘤病、乳头状汗管囊腺瘤syringocystadenoma papilliferum