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- B1590Interpretation: Ovarian stromal tumor with features of sclerosing stromal tumor and thecoma
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| 肉眼检查： | |||||
40-45 y/f with hx of cervical ca with radiation, chemotherapy, ovarian mass 11 cm. I did frozen. Gynecologist came to frozen room to sit with me to read frozen slide.
What can you tell your surgen about the case if your were the pathologist?
What is your differential dx?
I ordered IHC in frozen block and will know basic result tomorrow.
abin译：
20分钟前的卵巢肿瘤冰冻切片。我们能告诉妇科医生什么？
40-45岁女性，有宫颈癌病史和化疗、放疗史。卵巢肿块11cm。我做冰冻切片，妇科医生跑到冰冻室，和我坐在一起看冰冻切片。本例，如果你是病理医生，你能告诉手术医生什么？
你的鉴别诊断是什么？
我用冰冻切片做了免疫组化，明天会知道基本结果。
标签：卵巢 间质肿瘤
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本帖最后由 于 2009-07-24 08:08:00 编辑
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×参考诊断
卵巢间质肿瘤，伴硬化性间质瘤和卵泡膜瘤的特征
| 以下是引用njwbhuang在2009-4-23 16:16:00的发言： 常规染色切片肿瘤细胞排列成不规则的巢状、索状或单行。瘤细胞大小较一致，胞质略称嗜碱性，部分透亮。核卵圆形或圆形，染色质均匀，未见核分裂。间质水肿或纤细的纤维组织。这些形态发生于卵巢中最有可能的是类癌、粒层细胞瘤、转移性乳腺癌。需要做CgA、Syn、inhibin、calretinin、mammoglobin、GCDFP-15进行诊断了。期待最终结果。 |
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stevenshen 离线
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- 我同意huang+笃行者 老师的分析 and suggestion for IHC panel.
- Did not see necrosis or signet ring like cells on permanent sections + stroma more like part of the tumor rather than "desmoplastic", Picture 1 shows sharp demarcation of cell nest from surrounding paucicellular stroma, although no convincing microfollicles, C-E bodies, or nuclear groove
- With no history of breast carcinoma and a relatively young age, 可能会把 sex cord stromal tumor (粒层细胞瘤) 放在鉴别诊断的首位.
- Thanks for such a challenging frozen case! The photos are wonderful.
