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what tumors or bengin cells can have nuclear grooves or nuclear pseudoinclusion

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楼主 发表于 2009-02-05 11:35|举报|关注(0)
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天山望月 once gave me the duty for this summary. I transfered the duty to our cytopathology fellow. I list the result here. I am supprised to notic that so many tumors can have nuclear grooves or inclusion. You can add more to the list and pay attention to those that are important for diagnosis and differential diagnosis. 

 

Nuclear grooves

Benign

n       Goiter

n       Chronic thyroiditis

n       Thyroid follicular adenoma

n       Thyroid hyalinizing trabecular adenoma

n       Ovarian Brenner tumor

Malignant

n       Papillary thyroid carcinoma

n       Follicular carcinoma

n       Mucinous Bronchioalveolar  adenocarcinoma

n       Ovarian granulosa cell tumor

n       Ovarian transitional carcinoma

n       Papillary transitional cell carcinoma of bladder

n       Breast carcinoma (ductal, lobular, papillary, mucinous)

n       Papillary renal cell carcinoma (important for dx)

n       25% of other types of renal tumor

n       Thymic carcinoma

Low Malignant Potential

n        Solid pseudo-papillary  tumor(pancreas)

n       Pheochromocytoma

 

 

Nuclear Pseudoinclusions

Benign

n       Goiter

n       Chronic thyroiditis

n       Anti thyroid therapy

n       Hyalinizing trabecular adenoma

Malignant

n       Papillary thyroid carcinoma

n       Follicular carcinoma

n       Medullary carcinoma

n       Insular carcinoma

n       Giant and spindle cell carcinoma

n       Hürthle cell neoplasms

n       Malignant Melanoma

n       RCC

n       Mucinous Bronchioalveolar  adenocarcinoma

n       Hepatocellular carcinoma

n       Epithelioid Hemangioendothelioma

n       Malignant melanoma of soft tissues(clear cell sarcoma

n        

 

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