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what tumors or bengin cells can have nuclear grooves or nuclear pseudoinclusion

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楼主 发表于 2009-02-05 11:35|举报|关注(0)
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天山望月 once gave me the duty for this summary. I transfered the duty to our cytopathology fellow. I list the result here. I am supprised to notic that so many tumors can have nuclear grooves or inclusion. You can add more to the list and pay attention to those that are important for diagnosis and differential diagnosis. 

 

Nuclear grooves

Benign

n       Goiter

n       Chronic thyroiditis

n       Thyroid follicular adenoma

n       Thyroid hyalinizing trabecular adenoma

n       Ovarian Brenner tumor

Malignant

n       Papillary thyroid carcinoma

n       Follicular carcinoma

n       Mucinous Bronchioalveolar  adenocarcinoma

n       Ovarian granulosa cell tumor

n       Ovarian transitional carcinoma

n       Papillary transitional cell carcinoma of bladder

n       Breast carcinoma (ductal, lobular, papillary, mucinous)

n       Papillary renal cell carcinoma (important for dx)

n       25% of other types of renal tumor

n       Thymic carcinoma

Low Malignant Potential

n        Solid pseudo-papillary  tumor(pancreas)

n       Pheochromocytoma

 

 

Nuclear Pseudoinclusions

Benign

n       Goiter

n       Chronic thyroiditis

n       Anti thyroid therapy

n       Hyalinizing trabecular adenoma

Malignant

n       Papillary thyroid carcinoma

n       Follicular carcinoma

n       Medullary carcinoma

n       Insular carcinoma

n       Giant and spindle cell carcinoma

n       Hürthle cell neoplasms

n       Malignant Melanoma

n       RCC

n       Mucinous Bronchioalveolar  adenocarcinoma

n       Hepatocellular carcinoma

n       Epithelioid Hemangioendothelioma

n       Malignant melanoma of soft tissues(clear cell sarcoma

n        

 

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1 楼    发表于2009-02-07 13:01:00举报|引用
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以下是引用天山望月在2009-2-6 22:00:00的发言:

 再次谢谢赵博士和您的同事!总结的太好了!要牢记在心!

我曾遇到一例,甲状腺肿物,直径5cm,术中印片,明显核内包涵体,偶有核沟,无毛玻璃样核,良恶性不敢确定,做了冰冻,诊断良性,石蜡切片是良性,分析原因,以为是没固定好,现在才明白,甲状腺良性病变也有此特征。太重要了!

 

不好意思,我怎敢给赵博士任务,我只是觉得赵博士学识渊博,做事严谨,想学到赵博士收藏的好多宝贝呢,呵呵)

Cytopathology fellow does not mean 同事. I once explained these terms, pathology residents, pathology fellows, pathology attending in my last online talk. Wish some one can explain to 天山望月.
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